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HPTP

HPTP is a monoaminergic neurotoxin related to MPTP. It is the dehydration product of haloperidol. The agent is specifically a dopaminergic and serotonergic neurotoxin. HPTP is a prodrug of HPP+, which mediates its monoaminergic neurotoxicity. This is analogous to how MPP+ mediates the neurotoxicity of MPTP. Other related compounds include RHPTP and RHPP+.

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3D model (JSmol)
Interactive image
CAS Number
52669-92-8
ChEBI
CHEBI:177523
ChEMBL
ChEMBL3544895
ChemSpider
149659
CompTox Dashboard (EPA)
DTXSID80200642

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HPTP

Nodes14
Edges13
Triples12
Avg. degree1.86
Density0.142857
Components1

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HPTP

Top relations

is a · 2
HPTP → monoaminergic neurotoxin related to MPTP, prodrug of HPP
3D model (JSmol) · 1
HPTP → Interactive image
CAS Number · 1
HPTP → 52669-92-8
ChEBI · 1
HPTP → CHEBI:177523
ChEMBL · 1
HPTP → ChEMBL3544895
ChemSpider · 1
HPTP → 149659
CompTox Dashboard (EPA) · 1
HPTP → DTXSID80200642
Drug class · 1
HPTP → Serotonergic and dopaminergic neurotoxin
Formula · 1
HPTP → C21H21ClFNO
Molar mass · 1
HPTP → 357.85 g·mol−1

Important terminology Word statistics

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Important terminology

neurotoxin mptp monoaminergic related mediates neurotoxicity dopaminergic serotonergic dehydration product haloperidol prodrug rhptp agent specifically hpp analogous mpp compounds include

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
HPTP3D model (JSmol)Interactive image1.00infobox
HPTPCAS Number52669-92-81.00infobox
HPTPChEBICHEBI:1775231.00infobox
HPTPChEMBLChEMBL35448951.00infobox
HPTPChemSpider1496591.00infobox
HPTPCompTox Dashboard (EPA)DTXSID802006421.00infobox
HPTPDrug classSerotonergic and dopaminergic neurotoxin1.00infobox
HPTPFormulaC21H21ClFNO1.00infobox
HPTPMolar mass357.85 g·mol−11.00infobox
HPTPPubChem CID1711871.00infobox
HPTPis amonoaminergic neurotoxin related to MPTP0.90text
HPTPis aprodrug of HPP0.90text

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