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MNase-seq

MNase-seq, short for micrococcal nuclease digestion with deep sequencing, is a molecular biological technique that was first pioneered in 2006 to measure nucleosome occupancy in the C. elegans genome, and was subsequently applied to the human genome in 2008. Though, the term 'MNase-seq' had not been coined until a year later, in 2009. Briefly, this…

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Overview

History

Description

Extended Techniques

Comparison to other Chromatin Accessibility Assays

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Map overview Semantic statistics

MNase-seq

Nodes82
Edges81
Triples79
Avg. degree1.98
Density0.02439
Components1

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MNase-seq

Top relations

related to MNase-ChIP/CUT&RUN sequencing · 21
MNase-seq → And, Briefly, Cells, ChIP-seq, Classical ChIP-seq, CUT, Digestion, DNA, DNA-bound, Furthermore, MNase, MNase-antibody, MNase-based, Other, Recently, RUN, SDS/Triton X-100, The, Then, This
related to Description · 14
MNase-seq → Bowtie, Ca2, Chromatin, DNA, DNA-protein, Hence, If, In, MNase, Nucleosomes, Once, The, Then, This
related to DNase-seq · 11
MNase-seq → Additionally, An, As, At, Both, DHSs, DNA, DNase, DNase-seq, MNase, Next-Generation
related to FAIRE-seq · 10
MNase-seq → Crosslinking, DHSs, DNA, DNase-seq, FAIRE-seq, However, Next-Generation, The, Thus, Two
related to ATAC-seq · 8
MNase-seq → As, ATAC-seq, Despite, DNA, DNase-seq, It, PCR, The
related to Single-cell MNase-seq · 8
MNase-seq → DNA, DNase, FACS, First, MNase, PCR, Single-cell, The
related to Comparison to other Chromatin Accessibility Assays · 5
MNase-seq → All, ATAC-seq, ChIP-seq, DNase-seq, FAIRE-seq

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Important terminology

dna chromatin sequencing mnase atac-seq used digestion regions nucleosome faire-seq dnase-seq nuclease accessibility transcription micrococcal proteins nucleosomes first positioning use

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Bowtieinstance ofwith tools0.80text
DNase I hypersensitive sites as well as transcription factor binding sitesinstance ofThe use of MNase in single-cell assays results in increased detection of regions0.80text
MNase-seqrelated to ATAC-seqATAC-seq0.60section
MNase-seqrelated to ATAC-seqPCR0.60section
MNase-seqrelated to ATAC-seqAs0.60section
MNase-seqrelated to ATAC-seqDNase-seq0.60section
MNase-seqrelated to ATAC-seqIt0.60section
MNase-seqrelated to ATAC-seqThe0.60section
MNase-seqrelated to ATAC-seqDNA0.60section
MNase-seqrelated to ATAC-seqDespite0.60section
MNase-seqrelated to Comparison to other Chromatin Accessibility AssaysDNase-seq0.60section
MNase-seqrelated to Comparison to other Chromatin Accessibility AssaysFAIRE-seq0.60section

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