Importin

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Structure

Adaptor protein ARM Tandem N-terminal C-terminus

15 related topics

Human importin genes

Families IPO5 IPO8 IPO9 IPO11

13 related topics

Disease

Mutations Gametogenesis Embryogenesis Drosophila melanogaster Cancer

12 related topics

Discovery

Monomer Max Delbrück Center for Molecular Medicine Cytosolic Sequence identity Xenopus

10 related topics

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Domains: InterPro
HGNC: 6394
Locus: Chr. 3 q21.1
NCBI gene: 3836
OMIM: 600686
RefSeq: NP_002255

Topics to explore

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Overview

Karyopherin
Nuclear transport
Protein
Cell Eukaryotic cell
Cytoplasm
Nucleus Cell nucleus
Recognition sequences Recognition sequence
Nuclear localization sequences Nuclear localization sequence
Heterodimer
Pore complex Nuclear pore
Nuclear localization signal
Trimer Protein trimer
Ran Ran (gene)
GTP Guanosine triphosphate

Discovery

Monomer
Max Delbrück Center for Molecular Medicine
Cytosolic Cytosol
Sequence identity Sequence alignment
Xenopus
E.coli Escherichia coli
Ran Ran (biology)
Homologues Homology (biology)
IPO4
IPO7

Structure

Adaptor protein Signal transducing adaptor protein
ARM Armadillo repeat
Tandem Tandem repeat
N-terminal N-terminus
C-terminus
Amino acid
Superfamily Protein superfamily
HEAT HEAT repeat domain
Alpha helices Alpha helix
Turn Turn (biochemistry)
Bonds Chemical bonds
Nucleoporins Nucleoporin
Crystallographic X-ray crystallography
Motifs Sequence motif
Hydrophobic Hydrophobe

Nuclear protein import cycle

Diffusion
Binding affinity Dissociation constant
Ras-family GTPase Ras superfamily
Conformation Protein structure
Nup50 Nucleoporin 50
CAS (cellular apoptosis susceptibility protein) CAS/CSE protein family
Hydrolysed Hydrolysis
GAP GTPase-activating protein
GDP Guanosine diphosphate
GEF Guanine nucleotide exchange factor

Disease

Mutations Mutation
Gametogenesis
Embryogenesis
Drosophila melanogaster
Cancer
Breast cancer
Tumour suppressor gene
BRCA1 (breast cancer type 1 susceptibility protein) BRCA1
Melanoma
Viral pathologies Pathogen
Ebola virus Ebola virus disease
PY-STAT1 STAT1

Human importin genes

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

Map overview Semantic statistics

Nodes81

Edges80

Triples126

Avg. degree1.98

Density0.024691

Components1

How this topic connects Entity context

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Importin

Top relations

related to Discovery · 19

Importin → Dirk Görlich, Enno Hartmann, Importin-α, Importin-β, IPO4, IPO7, It, Max Delbrück Center, Michael Rexach, Molecular Medicine, NLS, Other, Ran, Since, SRP1p, TC4, The, These, Xenopus

related to Human importin genes · 17

Importin → Although, IPO11, IPO13Karyopherin-α, IPO4, IPO5, IPO7, IPO8, IPO9, KPNA1, KPNA2, KPNA3, KPNA4, KPNA5, KPNA6Karyopherin-β, KPNB1, Note, Various

related to Recycling · 14

Importin → CAS, Finally, GAP, GEF, GTP, Importin-β, In, It, Once, Ran, Ran-GDP, Ran-GTP, Ran-GTP/CAS, RanGAP

related to Importin-α · 12

Importin → ARM, As, C-terminus, IBB, Importin-α, Importin-β, N-terminal, N-terminus, NLS, The, These, This

related to Cargo release · 10

Importin → IBB, In, NLS, NLS-binding, Now, Nup2, Nup50, The, The N-terminal, This

related to Importin-β · 9

Importin → Crystallographic, Each, FG, HEAT, Importin-β, In, It, Phe-Gly, The

related to Cargo transport · 7

Importin → Importin-β, NPC, Once, Ran-GTP, Ras-family GTPase, The, This

related to External links · 6

Importin → Importins, Medicine Medical Subject Headings, MeSH, Month Importins, National Library, PDB Molecule

related to Disease · 4

Importin → As, Drosophila, Importins, There

related to Neuronal functions · 4

Importin → After, Subcellular, These, UTR

Important terminology Word statistics

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

protein importin-α importin-β cargo nucleus proteins cytoplasm nls nuclear binding transport also structure form complex two bind import ran-gtp ran

Entity relationships Subject–Predicate–Object triples

Subject	Predicate	Object	Confidence	Src
Importin	Domains	InterPro	1.00	infobox
Importin	HGNC	6394	1.00	infobox
Importin	Locus	Chr. 3 q21.1	1.00	infobox
Importin	NCBI gene	3836	1.00	infobox
Importin	OMIM	600686	1.00	infobox
Importin	RefSeq	NP_002255	1.00	infobox
Importin	Search for	Search forStructuresSwiss-modelDomainsInterPro	1.00	infobox
Importin	Structures	Swiss-model	1.00	infobox
Importin	Symbol	KPNA1	1.00	infobox
Importin	UniProt	P52294	1.00	infobox
Importin	is a	type of karyopherin involved in the nuclear transport of moving protein molecules from a cell's cytoplasm to the nucleus	0.90	text
Nup2	instance of	specific release factors	0.80	text

Related concept clusters Concept neighborhoods

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Connections between topic areas Semantic bridges

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