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Hexokinase I, also known as hexokinase A and HK1, is an enzyme that in humans is encoded by the HK1 gene on chromosome 10. Hexokinases phosphorylate glucose to produce glucose-6-phosphate (G6P), the first step in most glucose metabolism pathways. This gene encodes a ubiquitous form of hexokinase which localizes to the outer membrane of mitochondria.…
The analysis highlights Function, Clinical significance and Structure as prominent areas in the source structure around Hexokinase I.
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Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
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The extracted context around Hexokinase I shows recurring relationship patterns in the source. For example, Hexokinase I → ATP binding, canonical glycolysis, carbohydrate metabolic process, carbohydrate phosphorylation, catalytic activity, cellular glucose homeostasis, cilium, cytosol, establishment of protein localization to mitochondrion, fructokinase activity, glucokinase activity, glucose 6-phosphate metabolic process, glucose binding, glycolytic process, hexokinase activity, hexose metabolic process, identical protein binding, kinase activity, maintenance of protein location in mitochondrion, mannokinase activity Another extracted example is Hexokinase I → Activation, Akt, Another, ATP, ATP-dependent, ATP/ADP, Bcl-2, Furthermore, G6P, HK2, HK3, I-VDAC1, Moreover, OMM, OMM-bound, Physiological, Pi, PI3, Specifically, TNF-induced. Use these groups to spot repeated connection types before inspecting the individual relationships.
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hexokinase gene mitochondrial protein bp glucose metabolism also hk1 function g6p chromosome 10 c-terminal isoforms chr human band cell atp
TTTA extracted 173 structured relationships around Hexokinase I. Examples in this analysis include Hexokinase I → 2.7.1.1 → ↗ and Hexokinase I → Aliases → HK1, HK1-ta, HK1-tb, HK1-tc, HKD, HKI, HMSNR, HXK1, hexokinase 1, HK, hexokinase, RP79, NEDVIBA. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| Hexokinase I | 2.7.1.1 | ↗ | 1.00 | infobox |
| Hexokinase I | Aliases | HK1, HK1-ta, HK1-tb, HK1-tc, HKD, HKI, HMSNR, HXK1, hexokinase 1, HK, hexokinase, RP79, NEDVIBA | 1.00 | infobox |
| Hexokinase I | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1CZA, 1DGK, 1HKB, 1HKC, 1QHA, 4F9O, 4FOE, 4FOI, 4FPA, 4FPB | 1.00 | infobox |
| Hexokinase I | Band | 10q22.1 | 1.00 | infobox |
| Hexokinase I | Band | 10 B4|10 32.37 cM | 1.00 | infobox |
| Hexokinase I | Bgee | cerebellar vermis | 1.00 | infobox |
| Hexokinase I | Bgee | mucosa of pharynx | 1.00 | infobox |
| Hexokinase I | Bgee | pons | 1.00 | infobox |
| Hexokinase I | Bgee | cardiac muscle tissue of right atrium | 1.00 | infobox |
| Hexokinase I | Bgee | body of tongue | 1.00 | infobox |
| Hexokinase I | Bgee | spinal ganglia | 1.00 | infobox |
| Hexokinase I | Bgee | parotid gland | 1.00 | infobox |
| Hexokinase I | Bgee | sperm | 1.00 | infobox |
| Hexokinase I | Bgee | myocardium of left ventricle | 1.00 | infobox |
| Hexokinase I | Bgee | superior vestibular nucleus | 1.00 | infobox |
| Hexokinase I | Bgee | neural layer of retina | 1.00 | infobox |
| Hexokinase I | Bgee | seminiferous tubule | 1.00 | infobox |
| Hexokinase I | Bgee | spermatid | 1.00 | infobox |
| Hexokinase I | Bgee | subiculum | 1.00 | infobox |
| Hexokinase I | Bgee | piriform cortex | 1.00 | infobox |
| Hexokinase I | Bgee | retinal pigment epithelium | 1.00 | infobox |
| Hexokinase I | Bgee | dorsal tegmental nucleus | 1.00 | infobox |
| Hexokinase I | Bgee | central gray substance of midbrain | 1.00 | infobox |
| Hexokinase I | Bgee | dorsomedial hypothalamic nucleus | 1.00 | infobox |
| Hexokinase I | Bgee | superior colliculus | 1.00 | infobox |
| Hexokinase I | BioGPS | More reference expression data | 1.00 | infobox |
| Hexokinase I | Chr. | Chromosome 10 (human) | 1.00 | infobox |
| Hexokinase I | Chr. | Chromosome 10 (mouse) | 1.00 | infobox |
| Hexokinase I | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| Hexokinase I | End | 69,401,884 bp | 1.00 | infobox |
The concept neighborhoods around Hexokinase I bring nearby vocabulary together. In this analysis, examples include Mitochondrial, Cell and Metabolism. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For Hexokinase I, one of the stronger structural bridges in this analysis connects Hexokinase I with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around Hexokinase I to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Clinical significance & Structure, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — Hexokinase I · EN edition · Analysis: TopicsToTalkAbout