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Hexokinase I: Function, Clinical significance & Structure

Hexokinase I, also known as hexokinase A and HK1, is an enzyme that in humans is encoded by the HK1 gene on chromosome 10. Hexokinases phosphorylate glucose to produce glucose-6-phosphate (G6P), the first step in most glucose metabolism pathways. This gene encodes a ubiquitous form of hexokinase which localizes to the outer membrane of mitochondria.…

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Hexokinase I topic overview

The analysis highlights Function, Clinical significance and Structure as prominent areas in the source structure around Hexokinase I.

Related topics
88
Source areas
5
Connected nodes
93
Extracted relationships
173
Related term clusters
17
Bridge connections
93

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 33 topics
Clinical significance · 29 topics
Overview · 12 topics
Structure · 12 topics
Interactions · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

2.7.1.1
↗
Aliases
HK1, HK1-ta, HK1-tb, HK1-tc, HKD, HKI, HMSNR, HXK1, hexokinase 1, HK, hexokinase, RP79, NEDVIBA
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1CZA, 1DGK, 1HKB, 1HKC, 1QHA, 4F9O, 4FOE, 4FOI, 4FPA, 4FPB
Band
10q22.1 · 10 B4|10 32.37 cM
Bgee
cerebellar vermis · mucosa of pharynx · pons · cardiac muscle tissue of right atrium · body of tongue
BioGPS
More reference expression data

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Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure

Function

Clinical significance

Interactions

For the semantics nerds

You can skip this section if you’re here for content ideas and keyword inspiration.

Advanced semantic analysis

How Hexokinase I connects Entity context

The extracted context around Hexokinase I shows recurring relationship patterns in the source. For example, Hexokinase I → ATP binding, canonical glycolysis, carbohydrate metabolic process, carbohydrate phosphorylation, catalytic activity, cellular glucose homeostasis, cilium, cytosol, establishment of protein localization to mitochondrion, fructokinase activity, glucokinase activity, glucose 6-phosphate metabolic process, glucose binding, glycolytic process, hexokinase activity, hexose metabolic process, identical protein binding, kinase activity, maintenance of protein location in mitochondrion, mannokinase activity Another extracted example is Hexokinase I → Activation, Akt, Another, ATP, ATP-dependent, ATP/ADP, Bcl-2, Furthermore, G6P, HK2, HK3, I-VDAC1, Moreover, OMM, OMM-bound, Physiological, Pi, PI3, Specifically, TNF-induced. Use these groups to spot repeated connection types before inspecting the individual relationships.

Hexokinase I

Top relations

Gene ontology · 32
Hexokinase I → ATP binding, canonical glycolysis, carbohydrate metabolic process, carbohydrate phosphorylation, catalytic activity, cellular glucose homeostasis, cilium, cytosol, establishment of protein localization to mitochondrion, fructokinase activity, glucokinase activity, glucose 6-phosphate metabolic process, glucose binding, glycolytic process, hexokinase activity, hexose metabolic process, identical protein binding, kinase activity, maintenance of protein location in mitochondrion, mannokinase activity
related to Function · 22
Hexokinase I → Activation, Akt, Another, ATP, ATP-dependent, ATP/ADP, Bcl-2, Furthermore, G6P, HK2, HK3, I-VDAC1, Moreover, OMM, OMM-bound, Physiological, Pi, PI3, Specifically, TNF-induced
Bgee · 20
Hexokinase I → body of tongue, cardiac muscle tissue of right atrium, central gray substance of midbrain, cerebellar vermis, dorsal tegmental nucleus, dorsomedial hypothalamic nucleus, mucosa of pharynx, myocardium of left ventricle, neural layer of retina, parotid gland, piriform cortex, pons, retinal pigment epithelium, seminiferous tubule, sperm, spermatid, spinal ganglia, subiculum, superior colliculus, superior vestibular nucleus
RNA expression pattern · 20
Hexokinase I → body of tongue, cardiac muscle tissue of right atrium, central gray substance of midbrain, cerebellar vermis, dorsal tegmental nucleus, dorsomedial hypothalamic nucleus, mucosa of pharynx, myocardium of left ventricle, neural layer of retina, parotid gland, piriform cortex, pons, retinal pigment epithelium, seminiferous tubule, sperm, spermatid, spinal ganglia, subiculum, superior colliculus, superior vestibular nucleus
related to Gene · 12
Hexokinase I → Alternative, CCAAT, Ets-binding, GATA, HK-R, HK1, Meanwhile, Moreover, PBD, SP1, T1-6, The HK1
related to Clinical significance · 11
Hexokinase I → Changes, Charcot, Due, HMSNR, HNSHA, Likewise, Marie, Meanwhile, Mutations, Russe-type, Tooth
related to Neurodegenerative disorders · 11
Hexokinase I → BPD, Hexokinase, In Parkinson's, MPTP, OMM, Parkin, Parkin-mediated, SCHZ, Similarly, UPD, VDAC
related to Retinitis pigmentosa · 7
Hexokinase I → Alternatively, Cox11, HK1, Notably, Ranbp2, Since, Thus
related to Interactions · 6
Hexokinase I → ATPase, EAAT2, Hexokinase, Na, Parkin, VDAC
Band · 2
Hexokinase I → 10 B4|10 32.37 cM, 10q22.1

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

hexokinase gene mitochondrial protein bp glucose metabolism also hk1 function g6p chromosome 10 c-terminal isoforms chr human band cell atp

Hexokinase I relationships Subject–Predicate–Object triples

TTTA extracted 173 structured relationships around Hexokinase I. Examples in this analysis include Hexokinase I → 2.7.1.1 → ↗ and Hexokinase I → Aliases → HK1, HK1-ta, HK1-tb, HK1-tc, HKD, HKI, HMSNR, HXK1, hexokinase 1, HK, hexokinase, RP79, NEDVIBA. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Hexokinase I2.7.1.1↗1.00infobox
Hexokinase IAliasesHK1, HK1-ta, HK1-tb, HK1-tc, HKD, HKI, HMSNR, HXK1, hexokinase 1, HK, hexokinase, RP79, NEDVIBA1.00infobox
Hexokinase IAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1CZA, 1DGK, 1HKB, 1HKC, 1QHA, 4F9O, 4FOE, 4FOI, 4FPA, 4FPB1.00infobox
Hexokinase IBand10q22.11.00infobox
Hexokinase IBand10 B4|10 32.37 cM1.00infobox
Hexokinase IBgeecerebellar vermis1.00infobox
Hexokinase IBgeemucosa of pharynx1.00infobox
Hexokinase IBgeepons1.00infobox
Hexokinase IBgeecardiac muscle tissue of right atrium1.00infobox
Hexokinase IBgeebody of tongue1.00infobox
Hexokinase IBgeespinal ganglia1.00infobox
Hexokinase IBgeeparotid gland1.00infobox
Hexokinase IBgeesperm1.00infobox
Hexokinase IBgeemyocardium of left ventricle1.00infobox
Hexokinase IBgeesuperior vestibular nucleus1.00infobox
Hexokinase IBgeeneural layer of retina1.00infobox
Hexokinase IBgeeseminiferous tubule1.00infobox
Hexokinase IBgeespermatid1.00infobox
Hexokinase IBgeesubiculum1.00infobox
Hexokinase IBgeepiriform cortex1.00infobox
Hexokinase IBgeeretinal pigment epithelium1.00infobox
Hexokinase IBgeedorsal tegmental nucleus1.00infobox
Hexokinase IBgeecentral gray substance of midbrain1.00infobox
Hexokinase IBgeedorsomedial hypothalamic nucleus1.00infobox
Hexokinase IBgeesuperior colliculus1.00infobox
Hexokinase IBioGPSMore reference expression data1.00infobox
Hexokinase IChr.Chromosome 10 (human)1.00infobox
Hexokinase IChr.Chromosome 10 (mouse)1.00infobox
Hexokinase IDatabasesNCBI: entry; OMA: entry1.00infobox
Hexokinase IEnd69,401,884 bp1.00infobox

Related concept clusters Related term clusters

The concept neighborhoods around Hexokinase I bring nearby vocabulary together. In this analysis, examples include Mitochondrial, Cell and Metabolism. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Hexokinase I
    • Mitochondrial
    • Cell
    • Metabolism
    • Function
    • Glucose
    • Gene
    • Due
    • Kinase
    • Expressed
    • Glycolysis
    • Protein
    • Cells
  • hexokinase i
    • Mitochondrial
    • Cell
    • Metabolism
    • Function
    • Glucose
    • Gene
    • Due
    • Kinase
    • Expressed
    • Glycolysis
    • Protein
    • Cells
  • gene
    • Hk1
    • Chromosome
    • Location
    • Mutations
    • Human
    • Bp
    • Chr
    • Membrane
    • Mouse
    • Associated
    • Band
    • Due
  • glucose
    • Metabolism
    • Kinase
    • Phosphorylation
    • Isoforms
    • Cells
    • Function
    • Mitochondrial
    • Hexokinase
    • Location
    • Membrane
    • Mouse
    • Band
  • outer membrane of mitochondria
    • Outer
    • Binding
    • Activity
    • Retina
    • Location
    • Mitochondrial
    • Mouse
    • Band
    • Glycolytic
    • Human
    • Kinase
    • Phosphorylation
  • retina
    • Mouse
    • Glycolytic
    • Outer
    • Activity
    • Protein
    • Function
    • Metabolism
    • Mitochondrial
    • Location
    • Membrane
    • Band
    • Binding
  • function
    • Protein
    • Metabolism
    • Location
    • Mouse
    • Human
    • Retina
    • Cells
    • Hk1
    • Glucose
    • Mitochondrial
    • Hexokinase
    • Gene
  • red blood cells
    • Expressed
    • Glycolytic
    • Isoform
    • Function
    • Glucose
    • Metabolism
    • Location
    • Membrane
    • Mouse
    • Hexokinase
    • Human
    • Kinase

Connections between topic areas Semantic bridges

For Hexokinase I, one of the stronger structural bridges in this analysis connects Hexokinase I with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Hexokinase I — Function · splits 60 ⟂ 34
Hexokinase I — Clinical significance · splits 64 ⟂ 30
Hexokinase I — Overview · splits 81 ⟂ 13
Hexokinase I — Structure · splits 81 ⟂ 13
Hexokinase I — Interactions · splits 91 ⟂ 3

Map overview Semantic statistics

Hexokinase I

Nodes94
Edges93
Triples173
Avg. degree1.98
Density0.021277
Components1

Source & methodology

TTTA analyzes the structure around Hexokinase I to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Clinical significance & Structure, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Hexokinase I · EN edition · Analysis: TopicsToTalkAbout

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