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GPER

G protein-coupled estrogen receptor 1 (GPER), also known as G protein-coupled receptor 30 (GPR30), is a protein that in humans is encoded by the GPER gene. GPER binds to and is activated by the female sex hormone estradiol and is responsible for some of the rapid effects that estradiol has on cells.

Ligands, Role in normal tissues & Discovery

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Aliases
GPER1, Gper1, 6330420K13Rik, CMKRL2, Ceprl, FEG-1, GPCR-Br, Gper, Gpr30, CEPR, DRY12, LERGU, LERGU2, LyGPR, mER, G protein-coupled estrogen receptor 1
Band
7p22.3 · 5|5 G2
Bgee
body of stomach · middle frontal gyrus · fundus · frontal pole · paraflocculus of cerebellum
BioGPS
More reference expression data
Chr.
Chromosome 7 (human) · Chromosome 5 (mouse)
Databases
NCBI: entry; OMA: entry

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Overview

Discovery

Ligands

Function

Role in normal tissues

Advanced semantic analysis

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Map overview Semantic statistics

GPER

Nodes105
Edges104
Triples230
Avg. degree1.98
Density0.019048
Components1

How this topic connects Entity context

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GPER

Top relations

Gene ontology · 102
GPER → adenylate cyclase-activating G protein-coupled receptor signaling pathway, apoptotic chromosome condensation, apoptotic process, axon, axon terminus, cell cycle, cell differentiation, cell junction, cell projection, cellular response to estradiol stimulus, cellular response to glucose stimulus, cellular response to mineralocorticoid stimulus, cellular response to peptide hormone stimulus, cellular response to tumor necrosis factor, chromatin binding, cytoplasm, cytoplasmic vesicle, cytoplasmic vesicle membrane, cytoskeleton, dendrite
Bgee · 20
GPER → apex of heart, body of stomach, condyle, epithelium of stomach, external carotid artery, fossa, frontal pole, fundus, hand, internal carotid artery, middle frontal gyrus, otolith organ, paraflocculus of cerebellum, right adrenal cortex, right lobe of liver, substantia nigra, tendon of biceps brachii, testicle, trigeminal ganglion, utricle
RNA expression pattern · 20
GPER → apex of heart, body of stomach, condyle, epithelium of stomach, external carotid artery, fossa, frontal pole, fundus, hand, internal carotid artery, middle frontal gyrus, otolith organ, paraflocculus of cerebellum, right adrenal cortex, right lobe of liver, substantia nigra, tendon of biceps brachii, testicle, trigeminal ganglion, utricle
related to External links · 14
GPER → Basic, Clinical Pharmacology, Estrogen, International Union, Ion Channels, IUPHAR Database, Medicine, Medicine Medical Subject Headings, MeSH, National Library, Receptor, Receptors, This, United States National Library
related to Agonists · 11
GPER → DDE, DDT, Diarylpropionitrile, DPN, EquolEstradiolEthynylestradiolFulvestrant, G-1GenisteinGPER-L1GPER-L2HydroxytyrosolKeponeLNS8801NiacinNicotinamideNonylphenolOleuropeinProtocatechuic, ICI-182780, Methoxyestradiol2, PCB-4-OHAfimoxifeneAldosteroneAtrazineBisphenol ADaidzeinDDT, PPT, QuercetinRaloxifeneResveratrolSTXTamoxifenTectoridin
related to Discovery · 9
GPER → Based, GPCR, GPR30, However, In, RNA, Since, The, These
related to Ligands · 7
GPER → Although, CCL18, G-1, G15, G36, GPER-selective, Niacin
related to Reproductive tissue · 7
GPER → ERα, ERβ, Estradiol, GnRH, However, HPG, This
related to Central nervous system activity · 6
GPER → Contrarily, ERα, ERβ, Estradiol, It, There
related to Role in cancer · 6
GPER → Additionally, Although GPER, Consistent, In, Leydig, Many

Important terminology Word statistics

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Important terminology

estradiol receptor protein estrogen effects activation bp gene cancer also human protein-coupled erβ hormone chr band expression breast system found

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
GPERAliasesGPER1, Gper1, 6330420K13Rik, CMKRL2, Ceprl, FEG-1, GPCR-Br, Gper, Gpr30, CEPR, DRY12, LERGU, LERGU2, LyGPR, mER, G protein-coupled estrogen receptor 11.00infobox
GPERBand7p22.31.00infobox
GPERBand5|5 G21.00infobox
GPERBgeebody of stomach1.00infobox
GPERBgeemiddle frontal gyrus1.00infobox
GPERBgeefundus1.00infobox
GPERBgeefrontal pole1.00infobox
GPERBgeeparaflocculus of cerebellum1.00infobox
GPERBgeetendon of biceps brachii1.00infobox
GPERBgeeright lobe of liver1.00infobox
GPERBgeeapex of heart1.00infobox
GPERBgeetesticle1.00infobox
GPERBgeeright adrenal cortex1.00infobox
GPERBgeeexternal carotid artery1.00infobox
GPERBgeeotolith organ1.00infobox
GPERBgeeutricle1.00infobox
GPERBgeeinternal carotid artery1.00infobox
GPERBgeecondyle1.00infobox
GPERBgeefossa1.00infobox
GPERBgeetrigeminal ganglion1.00infobox
GPERBgeeepithelium of stomach1.00infobox
GPERBgeesubstantia nigra1.00infobox
GPERBgeehand1.00infobox
GPERBioGPSMore reference expression data1.00infobox
GPERChr.Chromosome 7 (human)1.00infobox
GPERChr.Chromosome 5 (mouse)1.00infobox
GPERDatabasesNCBI: entry; OMA: entry1.00infobox
GPEREnd1,093,815 bp1.00infobox
GPEREnd139,413,555 bp1.00infobox
GPEREnsemblENSG000001648501.00infobox

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