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CCL18

Chemokine (C-C motif) ligand 18 (CCL18) is a small cytokine belonging to the CC chemokine family. The functions of CCL18 have been well studied in laboratory settings, however the physiological effects of the molecule in living organisms have been difficult to characterize because there is no similar protein in rodents that can be studied. The receptor…

Receptor, Gene and protein structure & Involvement in disease

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Key facts & relationships

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Aliases
CCL18, chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated), AMAC-1, AMAC1, CKb7, DC-CK1, DCCK1, MIP-4, PARC, SCYA18, C-C motif chemokine ligand 18
Available structures
Available structuresPDBHuman UniProt search: PDBe RCSB List of PDB id codes4MHE
Band
17q12
Bgee
lymph node · upper lobe of left lung · appendix · rectum · right lung
BioGPS
n/a
Chr.
Chromosome 17 (human)

Topics to explore

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Overview

Gene and protein structure

Sources

Chemotactic functions

Receptor

Effector functions

Involvement in disease

Advanced semantic analysis

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Map overview Semantic statistics

CCL18

Nodes65
Edges64
Triples150
Avg. degree1.97
Density0.030769
Components1

How this topic connects Entity context

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CCL18

Top relations

Gene ontology · 25
CCL18 → antimicrobial humoral immune response mediated by antimicrobial peptide, CCR chemokine receptor binding, cell communication, cell-cell signaling, cellular response to interferon-gamma, cellular response to interleukin-1, cellular response to tumor necrosis factor, chemokine activity, chemokine-mediated signaling pathway, chemotaxis, cytokine activity, extracellular region, extracellular space, G protein-coupled receptor signaling pathway, immune response, inflammatory response, lymphocyte chemotaxis, monocyte chemotaxis, neutrophil chemotaxis, positive regulation of ERK1 and ERK2 cascade
related to Receptor · 24
CCL18 → B-cells, CCL1, CCL18's, CCL18-mediated, CCR8, CCR8's, CCR8-CCL18, CXCL12-dependent, Following, Further, Furthermore, G-protein, GPCR, GPCRs, GPR30, However, PITPNM3, PITPNM3-CCL8, Pyk2, Src
related to Sources · 12
CCL18 → B-cells, Finally, Furthermore, IFN-gamma, IL-10, IL-13, IL-4, Its, Neither T-cells, T-helper, The, These
Bgee · 10
CCL18 → appendix, duodenum, gallbladder, left coronary artery, lymph node, rectum, right coronary artery, right lung, spleen, upper lobe of left lung
RNA expression pattern · 10
CCL18 → appendix, duodenum, gallbladder, left coronary artery, lymph node, rectum, right coronary artery, right lung, spleen, upper lobe of left lung
related to Chemotactic functions · 10
CCL18 → B-cells, Chemokines, Dendritic Cells, FoxP3, IL-10, It, T-cells, T-helper, T-regulatory, The T-regulatory
related to Immune activation · 10
CCL18 → B-cells, Coupled, Finally, Furthermore, IL-13, IL-4, Perhaps, T-helper, Th2, The
related to Immunosuppression · 7
CCL18 → Furthermore, IL-10, In, M2, T-cell, T-cells, T-regulatory
related to Autoimmunity and hypersensitivity · 6
CCL18 → Allergic, Furthermore, However, In, T-cells, T-helper
related to Breast cancer · 5
CCL18 → Perhaps CCL18, PITPNM3, T-cells, T-regulatory, The

Important terminology Word statistics

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Important terminology

cells immune receptor t-helper gene expressed dendritic t-cells cytokine functions protein involved chemokine binding human also role system effects effector

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
CCL18AliasesCCL18, chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated), AMAC-1, AMAC1, CKb7, DC-CK1, DCCK1, MIP-4, PARC, SCYA18, C-C motif chemokine ligand 181.00infobox
CCL18Available structuresAvailable structuresPDBHuman UniProt search: PDBe RCSB List of PDB id codes4MHE1.00infobox
CCL18Band17q121.00infobox
CCL18Bgeelymph node1.00infobox
CCL18Bgeeupper lobe of left lung1.00infobox
CCL18Bgeeappendix1.00infobox
CCL18Bgeerectum1.00infobox
CCL18Bgeeright lung1.00infobox
CCL18Bgeeduodenum1.00infobox
CCL18Bgeespleen1.00infobox
CCL18Bgeegallbladder1.00infobox
CCL18Bgeeright coronary artery1.00infobox
CCL18Bgeeleft coronary artery1.00infobox
CCL18BioGPSn/a1.00infobox
CCL18Chr.Chromosome 17 (human)1.00infobox
CCL18DatabasesNCBI: entry; OMA: entry1.00infobox
CCL18End36,072,032 bp1.00infobox
CCL18EnsemblENSG00000275385 ENSG00000278167 ENSG000002780061.00infobox
CCL18Entrez63621.00infobox
CCL18External IDsOMIM: 603757; GeneCards: CCL181.00infobox
CCL18Gene location (Human)Gene location (Human)Chr.Chromosome 17 (human)Band17q12Start36,064,272 bpEnd36,072,032 bp1.00infobox
CCL18Gene ontologycytokine activity1.00infobox
CCL18Gene ontologyprotein binding1.00infobox
CCL18Gene ontologyCCR chemokine receptor binding1.00infobox
CCL18Gene ontologychemokine activity1.00infobox
CCL18Gene ontologyextracellular region1.00infobox
CCL18Gene ontologyextracellular space1.00infobox
CCL18Gene ontologyG protein-coupled receptor signaling pathway1.00infobox
CCL18Gene ontologymonocyte chemotaxis1.00infobox
CCL18Gene ontologychemokine-mediated signaling pathway1.00infobox

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