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Enobosarm

Enobosarm, also formerly known as ostarine and by the developmental code names GTx-024, MK-2866, and S-22, is a selective androgen receptor modulator (SARM) which is under development for the treatment of androgen receptor-positive breast cancer in women and for improvement of body composition (e.g., prevention of muscle loss) in people taking GLP-1…

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3D model (JSmol)
Interactive image
ATC code
None
Bioavailability
100% (rats)
CAS Number
841205-47-8
ChEMBL
ChEMBL1738889
ChemSpider
9501667

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Overview

Side effects

Overdose

Interactions

Pharmacology

Chemistry

History

Society and culture

Research

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Map overview Semantic statistics

Enobosarm

Nodes301
Edges300
Triples161
Avg. degree1.99
Density0.006645
Components1

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Enobosarm

Top relations

related to history · 27
Enobosarm → AR, As, At, By, Co, Dalton, Europe, GTx, GTx-007, GTx-024, GTx-758, In, In August, James, Memphis, Merck, S-22, S-4, SARM, SARM-type
related to Pharmacodynamics · 18
Enobosarm → Although, Another, AR, AR-expressing, DHT, However, In, Induction, Ki, LGD-2226, MCF-7, MDA-MB-231, N/C, SARM, SARMs, The, The AR, This
related to Non-medical use · 17
Enobosarm → Aside, Doses, GTx-007, In, Internet, LGD-4033, London, Many, MDMA, Netherlands, RAD140, S-4, SARMs, Social, These, VK5211, While
has effect · 13
Enobosarm → Decreases, Despite, DHT, For, FSH, General, HDL, In, It, LDL, LH, SHBG, Small
related to Interactions · 13
Enobosarm → Based, BCRP, CYP2C9, CYP3A4, It, P450, P50, Since, The, UDP-glucuronosyltransferase, UGT, UGT1A1, UGT2B7
related to Names · 11
Enobosarm → GTx, GTx-024, Inc, INN, International Nonproprietary Name, Merck, MK-2866, Ostarine, S-22, Veru, VERU-024
related to Chemistry · 9
Enobosarm → Bicalutamide, GTx-007, GTx-027, S-1, S-4, SARM S-1, SARM-like, SARMs, They
related to External links · 7
Enobosarm → AdisInsight, GTx-024, MK-2866, Ostarine, S-22, Veru Healthcare, VERU-024
related to Research · 7
Enobosarm → Consequent, Duchenne, FDA, However, Instead, It, The
related to Doping in sport · 5
Enobosarm → For, January, SARMs, There, World Anti-Doping Agency

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Important terminology

effects muscle clinical trials doses mg like testosterone sarms day drug phase development also levels anabolic cancer prostate may women

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Enobosarm3D model (JSmol)Interactive image1.00infobox
EnobosarmATC codeNone1.00infobox
EnobosarmBioavailability100% (rats)1.00infobox
EnobosarmCAS Number841205-47-81.00infobox
EnobosarmChEMBLChEMBL17388891.00infobox
EnobosarmChemSpider95016671.00infobox
EnobosarmCompTox Dashboard (EPA)DTXSID302330061.00infobox
EnobosarmDrugBankDB12078 Y1.00infobox
EnobosarmElimination half-life14–24 hours1.00infobox
EnobosarmExcretionFeces (70%), urine (21–25%) (rats)1.00infobox
EnobosarmFormulaC19H14F3N3O31.00infobox
EnobosarmKEGGD102211.00infobox
EnobosarmLegal statusUS: Investigational New Drug1.00infobox
EnobosarmMelting point132 to 136 °C (270 to 277 °F)1.00infobox
EnobosarmMetabolismCYP3A4, UGT1A1, UGT2B71.00infobox
EnobosarmMetabolitesEnobosarm glucuronide1.00infobox
EnobosarmMolar mass389.334 g·mol−11.00infobox
EnobosarmOther namesOstarine; GTx-024; MK-2866; S-22; VERU-0241.00infobox
EnobosarmPDB ligandRLJ (PDBe, RCSB PDB)1.00infobox
EnobosarmPubChem CID113267151.00infobox
EnobosarmRoutes of administrationBy mouth1.00infobox
EnobosarmUNIIO3571H3R8N1.00infobox
Enobosarmis anonsteroidal SARM0.90text
Enobosarmis asubstrate of CYP3A4 and UGT enzymes.The metabolism of enobosarm is similar to that of the closely structurally related drug bicalutamide.EliminationIn rats0.90text
Enobosarmis asubstrate of CYP3A4 and UGT enzymes.The metabolism of enobosarm is similar to that of the closely structurally related drug bicalutamide0.90text

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