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Progesterone (medication)

Progesterone (P4), sold under the brand name Prometrium among others, is a medication and naturally occurring steroid hormone. It is a progestogen and is used in combination with estrogens mainly in hormone therapy for menopausal symptoms, and low sex hormone levels in women, as well as gender affirming therapy in transgender women. It is also used in…

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3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
G03DA04 (WHO)
Bioavailability
Oral: <2.4% Vaginal (micronized insert): 4–8%
CAS Number
57-83-0 Y
ChEBI
CHEBI:17026 Y

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Overview

Medical uses

Contraindications

Side effects

Overdose

Interactions

Pharmacology

Chemistry

History

Society and culture

Research

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Map overview Semantic statistics

Progesterone (medication)

Nodes389
Edges388
Triples55
Avg. degree1.99
Density0.005141
Components1

How this topic connects Entity context

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Progesterone (medication)

Top relations

Legal status · 3
Progesterone (medication) → AU: S4 (Prescription only), CA: ℞-only, In general: ℞ (Prescription only)
3D model (JSmol) · 1
Progesterone (medication) → Interactive image
AHFS/Drugs.com · 1
Progesterone (medication) → Monograph
ATC code · 1
Progesterone (medication) → G03DA04 (WHO)
Bioavailability · 1
Progesterone (medication) → Oral: 2.4% Vaginal (micronized insert): 4–8%
CAS Number · 1
Progesterone (medication) → 57-83-0 Y
ChEBI · 1
Progesterone (medication) → CHEBI:17026 Y
ChEMBL · 1
Progesterone (medication) → ChEMBL103 Y
ChemSpider · 1
Progesterone (medication) → 5773 Y
Drug class · 1
Progesterone (medication) → Progestogen; Antimineralocorticoid; Neurosteroid

Important terminology Word statistics

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Important terminology

progesterone oral vaginal brand women effects breast also marketed name use intramuscular estrogen injection available used may estradiol found first

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Progesterone (medication)3D model (JSmol)Interactive image1.00infobox
Progesterone (medication)AHFS/Drugs.comMonograph1.00infobox
Progesterone (medication)ATC codeG03DA04 (WHO)1.00infobox
Progesterone (medication)BioavailabilityOral: <2.4% Vaginal (micronized insert): 4–8%1.00infobox
Progesterone (medication)CAS Number57-83-0 Y1.00infobox
Progesterone (medication)ChEBICHEBI:17026 Y1.00infobox
Progesterone (medication)ChEMBLChEMBL103 Y1.00infobox
Progesterone (medication)ChemSpider5773 Y1.00infobox
Progesterone (medication)Drug classProgestogen; Antimineralocorticoid; Neurosteroid1.00infobox
Progesterone (medication)DrugBankDB00396 Y1.00infobox
Progesterone (medication)Elimination half-life• Oral: 5 hours (with food) * Sublingual: 6–7 hours • Vaginal: 14–50 hours • Topical: 30–40 hours • IM: 20–28 hours • SC: 13–18 hours • IVTooltip Intravenous injection: 3–90 min…1.00infobox
Progesterone (medication)ExcretionBile and urine1.00infobox
Progesterone (medication)FormulaC21H30O21.00infobox
Progesterone (medication)IUPHAR/BPS23771.00infobox
Progesterone (medication)KEGGD00066 Y1.00infobox
Progesterone (medication)Legal statusAU: S4 (Prescription only)1.00infobox
Progesterone (medication)Legal statusCA: ℞-only1.00infobox
Progesterone (medication)Legal statusIn general: ℞ (Prescription only)1.00infobox
Progesterone (medication)MedlinePlusa6040171.00infobox
Progesterone (medication)Melting point126 °C (259 °F)1.00infobox
Progesterone (medication)MetabolismMainly liver: • 5α- and 5β-reductase • 3α-Tooltip 3α-Hydroxysteroid dehydrogenase and 3β-HSDTooltip 3β-Hydroxysteroid dehydrogenase • 20α-Tooltip 20α-Hydroxysteroid dehydrogenas…1.00infobox
Progesterone (medication)Metabolites• Dihydroprogesterones • Pregnanolones • Pregnanediols • 20α-Hydroxyprogesterone • 17α-Hydroxyprogesterone • Pregnanetriols • 11-Deoxycorticosterone (and glucuronide/sulfate con…1.00infobox
Progesterone (medication)Molar mass314.469 g·mol−11.00infobox
Progesterone (medication)Other namesP4; Pregnenedione; Pregn-4-ene-3,20-dione1.00infobox
Progesterone (medication)Protein binding98–99%: • Albumin: 80% • CBGTooltip Corticosteroid-binding globulin: 18% • SHBGTooltip Sex hormone-binding globulin: <1% • Free: 1–2%1.00infobox
Progesterone (medication)PubChem CID59941.00infobox
Progesterone (medication)Routes of administrationBy mouth, sublingual, topical, vaginal, rectal, intramuscular, subcutaneous, intrauterine1.00infobox
Progesterone (medication)Specific rotation[α]D25 = +172 to +182° (2% in dioxane, β-form)1.00infobox
Progesterone (medication)Trade namesPrometrium, Utrogestan, Endometrin, others1.00infobox
Progesterone (medication)UNII4G7DS2Q64Y1.00infobox

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