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Levodopa

Levodopa, also known as L-DOPA, is a dopaminergic medication which is used in the treatment of Parkinson's disease (PD) and certain other conditions like dopamine-responsive dystonia and restless legs syndrome. The drug is usually used and formulated in combination with a peripherally selective aromatic L-amino acid decarboxylase (AAAD) inhibitor like…

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3D model (JSmol)
Interactive image
AHFS/Drugs.com
Professional Drug Facts
ATC code
N04BA01 (WHO)
Bioavailability
30%
CAS Number
59-92-7 Y
ChEBI
CHEBI:15765 Y

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Overview

Medical uses

Side effects

Pharmacology

Chemistry

History

Society and culture

  • Generic name Generic term
  • INN International Nonproprietary Name
  • USAN United States Adopted Name
  • USP United States Pharmacopeia
  • BAN British Approved Name
  • DCF Dénomination Commune Française
  • DCIT Denominazione Comune Italiana
  • JAN Japanese Accepted Name

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Map overview Semantic statistics

Levodopa

Nodes180
Edges179
Triples102
Avg. degree1.99
Density0.011111
Components1

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Levodopa

Top relations

related to history · 17
Levodopa → Arvid Carlsson, George Cotzias, Guggenheim, In, It, Lasker Prize, Marcus Guggenheim, Nobel Prize, Oleh Hornykiewicz, Parkinson's, Parkinsonian, Swedish, The, This, Torquato Torquati, Vicia, Walther Birkmayer
related to Medical uses · 13
Levodopa → AAAD, B6, Because, Bradykinesia, DDC, DOPA, Once, Parkinson's, Parkinson-plus, Pyridoxal, Speech, The, Thus
related to Names · 8
Levodopa → BANTooltip British Approved Name, DCFTooltip Dénomination Commune Française, DCITTooltip Denominazione Comune Italiana, INNTooltip International Nonproprietary Name, JANTooltip Japanese Accepted Name, Name, USANTooltip United States Adopted, USPTooltip United States Pharmacopeia
related to Pharmacodynamics · 7
Levodopa → D1, D1-like, D2, D2-like, D3, D4, D5
related to External links · 5
Levodopa → Archived, Drug Information Portal, January, Medicine, National Library
Legal status · 4
Levodopa → AU: S4 (Prescription only), EU: Rx-only, UK: POM (Prescription only), US: ℞-only (some forms are OTC)
related to Chemistry · 4
Levodopa → Analogues, Parkinson's, Some, XP-21279
has effect · 3
Levodopa → Gastrointestinal, Hypertension, The
related to Age-related macular degeneration · 3
Levodopa → AMD, In, The
related to Pharmacokinetics · 3
Levodopa → AAAD, It, The

Important terminology Word statistics

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Important terminology

dopamine effects treatment administration disease drug parkinson's carbidopa syndrome dopaminergic side acid used foslevodopa decarboxylase first like neurons precursor combination

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Levodopa3D model (JSmol)Interactive image1.00infobox
LevodopaAHFS/Drugs.comProfessional Drug Facts1.00infobox
LevodopaATC codeN04BA01 (WHO)1.00infobox
LevodopaBioavailability30%1.00infobox
LevodopaCAS Number59-92-7 Y1.00infobox
LevodopaChEBICHEBI:15765 Y1.00infobox
LevodopaChEMBLChEMBL1009 Y1.00infobox
LevodopaChemSpider5824 Y1.00infobox
LevodopaCompTox Dashboard (EPA)DTXSID90232091.00infobox
LevodopaDrug classDopamine precursor; Dopamine receptor agonist1.00infobox
LevodopaDrugBankDB01235 Y1.00infobox
LevodopaECHA InfoCard100.000.4051.00infobox
LevodopaElimination half-life0.75–1.5 hours1.00infobox
LevodopaExcretionRenal 70–80%1.00infobox
LevodopaFormulaC9H11NO41.00infobox
LevodopaIUPHAR/BPS36391.00infobox
LevodopaKEGGD00059 Y1.00infobox
LevodopaLegal statusAU: S4 (Prescription only)1.00infobox
LevodopaLegal statusUK: POM (Prescription only)1.00infobox
LevodopaLegal statusUS: ℞-only (some forms are OTC)1.00infobox
LevodopaLegal statusEU: Rx-only1.00infobox
LevodopaLicense dataEU EMA: by INN1.00infobox
LevodopaLicense dataUS DailyMed: Levodopa1.00infobox
LevodopaMedlinePlusa6190181.00infobox
LevodopaMetabolismAromatic-.mw-parser-output span.smallcaps{font-variant:small-caps}.mw-parser-output span.smallcaps-smaller{font-size:85%}l-amino-acid decarboxylase1.00infobox
LevodopaMetabolites• Dopamine1.00infobox
LevodopaMolar mass197.190 g·mol−11.00infobox
LevodopaOther namesL-DOPA1.00infobox
LevodopaPregnancy categoryAU: B31.00infobox
LevodopaPronunciation/ˌɛlˈdoʊpə/, /ˌlɛvoʊˈdoʊpə/1.00infobox

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