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Explore the main themes, entities and connections around Dihydrofolate reductase. Start with the topic map, then use the sections below for research and deeper semantic analysis.

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Therapeutic applications

Thymine Antibiotic Methotrexate Chemotherapy Resistance

14 related topics

Function

Dihydrofolate Tetrahydrofolate Purines Thymidylic acid Amino acids

10 related topics

Structure

Beta-pleated sheet Polypeptide Alpha helices Active site N-terminal

9 related topics

As a research tool

Protein–protein interactions Protein-fragment complementation assay CHO cells Cell line Transfected

9 related topics

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

1.5.1.3: ↗
Aliases: DHFR, DHFRP1, DYR, dihydrofolate reductase
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1BOZ, 1DHF, 1DLR, 1DLS, 1DRF, 1HFP, 1HFQ, 1HFR, 1KMS, 1KMV, 1MVS, 1MVT, 1OHJ, 1OHK, 1PD8, 1PD9, 1PDB, 1S3U,…
Band: 5q14.1 · 13 C3|13 47.64 cM
Bgee: buccal mucosa cell · ventricular zone · ganglionic eminence · trabecular bone · bone marrow
BioGPS: n/a

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Overview

Function

Structure

Mechanism

Clinical significance

Therapeutic applications

As a research tool

Protein–protein interactions
Protein-fragment complementation assay
CHO cells Chinese hamster ovary cell
Cell line
Transfected Transfection
Plasmid
Expression system
Selective conditions Selection (biology)
Medium Growth medium

Interactions

Advanced semantic analysis

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Map overview Semantic statistics

Dihydrofolate reductase

Nodes75

Edges74

Triples120

Avg. degree1.97

Density0.026667

Components1

How this topic connects Entity context

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Dihydrofolate reductase

Top relations

Gene ontology · 27

Dihydrofolate reductase → axon regeneration, cellular component, cytoplasm, cytosol, dihydrofolate metabolic process, dihydrofolate reductase activity, folate reductase activity, folic acid binding, folic acid metabolic process, methotrexate binding, mitochondrion, mRNA binding, NADP binding, NADPH binding, negative regulation of translation, one-carbon metabolic process, oxidoreductase activity, positive regulation of nitric-oxide synthase activity, regulation of removal of superoxide radicals, regulation of transcription involved in G1/S transition of mitotic cell cycle

Bgee · 20

Dihydrofolate reductase → abdominal wall, bone marrow, bone marrow cell, buccal mucosa cell, efferent ductule, endothelial cell, epiblast, ganglionic eminence, Gonadal ridge, human fetus, inferior ganglion of vagus nerve, jejunal mucosa, mandibular prominence, maxillary prominence, oocyte, Paneth cell, primitive streak, somite, trabecular bone, ventricular zone

RNA expression pattern · 20

related to External links · 7

Dihydrofolate reductase → Dihydrofolate, MedicineProteopedia, Nobel, P00374, PDB, PDBe-KB, UniProt

related to Function · 5

Dihydrofolate reductase → DHFR, Dihydrofolate, Reaction, Tetrahydrofolate, While

related to Interactions · 3

Dihydrofolate reductase → Dihydrofolate, GroEL, Mdm2

Band · 2

Dihydrofolate reductase → 13 C3|13 47.64 cM, 5q14.1

Chr. · 2

Dihydrofolate reductase → Chromosome 13 (mouse), Chromosome 5 (human)

End · 2

Dihydrofolate reductase → 80,654,983 bp, 92,525,561 bp

related to Clinical significance · 2

Dihydrofolate reductase → DHFR, These

Important terminology Word statistics

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Important terminology

dhfr dihydrofolate nadph tetrahydrofolate enzyme site reductase binding active gene substrate transfer chromosome bp met20 trimethoprim r67 chr human band

Entity relationships Subject–Predicate–Object triples

Subject	Predicate	Object	Confidence	Src
Dihydrofolate reductase	1.5.1.3	↗	1.00	infobox
Dihydrofolate reductase	Aliases	DHFR, DHFRP1, DYR, dihydrofolate reductase	1.00	infobox
Dihydrofolate reductase	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1BOZ, 1DHF, 1DLR, 1DLS, 1DRF, 1HFP, 1HFQ, 1HFR, 1KMS, 1KMV, 1MVS, 1MVT, 1OHJ, 1OHK, 1PD8, 1PD9, 1PDB, 1S3U,…	1.00	infobox
Dihydrofolate reductase	Band	5q14.1	1.00	infobox
Dihydrofolate reductase	Band	13 C3\|13 47.64 cM	1.00	infobox
Dihydrofolate reductase	Bgee	buccal mucosa cell	1.00	infobox
Dihydrofolate reductase	Bgee	ventricular zone	1.00	infobox
Dihydrofolate reductase	Bgee	ganglionic eminence	1.00	infobox
Dihydrofolate reductase	Bgee	trabecular bone	1.00	infobox
Dihydrofolate reductase	Bgee	bone marrow	1.00	infobox
Dihydrofolate reductase	Bgee	bone marrow cell	1.00	infobox
Dihydrofolate reductase	Bgee	oocyte	1.00	infobox
Dihydrofolate reductase	Bgee	inferior ganglion of vagus nerve	1.00	infobox
Dihydrofolate reductase	Bgee	jejunal mucosa	1.00	infobox
Dihydrofolate reductase	Bgee	endothelial cell	1.00	infobox
Dihydrofolate reductase	Bgee	abdominal wall	1.00	infobox
Dihydrofolate reductase	Bgee	primitive streak	1.00	infobox
Dihydrofolate reductase	Bgee	human fetus	1.00	infobox
Dihydrofolate reductase	Bgee	mandibular prominence	1.00	infobox
Dihydrofolate reductase	Bgee	maxillary prominence	1.00	infobox
Dihydrofolate reductase	Bgee	epiblast	1.00	infobox
Dihydrofolate reductase	Bgee	Gonadal ridge	1.00	infobox
Dihydrofolate reductase	Bgee	efferent ductule	1.00	infobox
Dihydrofolate reductase	Bgee	Paneth cell	1.00	infobox
Dihydrofolate reductase	Bgee	somite	1.00	infobox
Dihydrofolate reductase	BioGPS	n/a	1.00	infobox
Dihydrofolate reductase	Chr.	Chromosome 5 (human)	1.00	infobox
Dihydrofolate reductase	Chr.	Chromosome 13 (mouse)	1.00	infobox
Dihydrofolate reductase	Databases	NCBI: entry; OMA: entry	1.00	infobox
Dihydrofolate reductase	End	80,654,983 bp	1.00	infobox

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