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ICAM3

Intercellular adhesion molecule 3 (ICAM3) also known as CD50 (Cluster of Differentiation 50), is a protein that in humans is encoded by the ICAM3 gene. The protein is constitutively expressed on the surface of leukocytes, which are also called white blood cells and are part of the immune system. ICAM3 mediates adhesion between cells by binding to…

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Aliases
ICAM3, CD50, CDW50, ICAM-R, intercellular adhesion molecule 3
Available structures
Available structuresPDBHuman UniProt search: PDBe RCSB List of PDB id codes1T0P
Band
19p13.2
Bgee
blood · granulocyte · monocyte · bone marrow cell · trabecular bone
BioGPS
More reference expression data
Chr.
Chromosome 19 (human)

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ICAM3

Nodes32
Edges31
Triples82
Avg. degree1.94
Density0.0625
Components1

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ICAM3

Top relations

Gene ontology · 14
ICAM3 → cell adhesion, cell-cell adhesion, extracellular exosome, extracellular matrix organization, integral component of membrane, integral component of plasma membrane, integrin binding, membrane, phagocytosis, plasma membrane, protein binding, regulation of immune response, signaling receptor binding, stimulatory C-type lectin receptor signaling pathway
Bgee · 10
ICAM3 → appendix, blood, bone marrow cell, granulocyte, lymph node, monocyte, periodontal fiber, right lobe of liver, spleen, trabecular bone
RNA expression pattern · 10
ICAM3 → appendix, blood, bone marrow cell, granulocyte, lymph node, monocyte, periodontal fiber, right lobe of liver, spleen, trabecular bone
related to Dendritic and T cell binding · 6
ICAM3 → Binding, DC-SIGN, MHC, Resting, TCR, This
related to External links · 6
ICAM3 → Medicine, Medicine Medical Subject Headings, MeSH, National Library, This, United States National Library
related to Apoptosis · 5
ICAM3 → Apoptotic, CD14, Interactions, These, This
related to Additional interactions · 2
ICAM3 → ERM, EZR
related to Integrins · 2
ICAM3 → LFA-1, To
related to Mast cells · 2
ICAM3 → HMC-1, Mast
related to Protein structure · 2
ICAM3 → ICAM, Like

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Important terminology

cells also binding cell adhesion protein integrin interactions dendritic expressed macrophages human surface apoptotic phagocytosis immune gene receptor process bp

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
ICAM3AliasesICAM3, CD50, CDW50, ICAM-R, intercellular adhesion molecule 31.00infobox
ICAM3Available structuresAvailable structuresPDBHuman UniProt search: PDBe RCSB List of PDB id codes1T0P1.00infobox
ICAM3Band19p13.21.00infobox
ICAM3Bgeeblood1.00infobox
ICAM3Bgeegranulocyte1.00infobox
ICAM3Bgeemonocyte1.00infobox
ICAM3Bgeebone marrow cell1.00infobox
ICAM3Bgeetrabecular bone1.00infobox
ICAM3Bgeeperiodontal fiber1.00infobox
ICAM3Bgeespleen1.00infobox
ICAM3Bgeelymph node1.00infobox
ICAM3Bgeeright lobe of liver1.00infobox
ICAM3Bgeeappendix1.00infobox
ICAM3BioGPSMore reference expression data1.00infobox
ICAM3Chr.Chromosome 19 (human)1.00infobox
ICAM3DatabasesNCBI: entry; OMA: entry1.00infobox
ICAM3End10,339,661 bp1.00infobox
ICAM3EnsemblENSG000000766621.00infobox
ICAM3Entrez33851.00infobox
ICAM3External IDsOMIM: 146631; GeneCards: ICAM31.00infobox
ICAM3Gene location (Human)Gene location (Human)Chr.Chromosome 19 (human)Band19p13.2Start10,333,776 bpEnd10,339,661 bp1.00infobox
ICAM3Gene ontologyintegrin binding1.00infobox
ICAM3Gene ontologysignaling receptor binding1.00infobox
ICAM3Gene ontologyprotein binding1.00infobox
ICAM3Gene ontologyintegral component of membrane1.00infobox
ICAM3Gene ontologyplasma membrane1.00infobox
ICAM3Gene ontologyintegral component of plasma membrane1.00infobox
ICAM3Gene ontologyextracellular exosome1.00infobox
ICAM3Gene ontologymembrane1.00infobox
ICAM3Gene ontologycell adhesion1.00infobox

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