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CD23: Standards, Clinical significance & Overview

CD23, also known as Fc epsilon RII, or FcεRII, is the "low-affinity" receptor for IgE, an antibody isotype involved in allergy and resistance to parasites, and is important in regulation of IgE levels. Unlike many of the antibody receptors, CD23 is a C-type lectin. It is found on mature B cells, activated macrophages, eosinophils, follicular dendritic…

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CD23 topic overview

The analysis highlights Standards, Clinical significance and Overview as prominent areas in the source structure around CD23.

Related topics
23
Source areas
2
Connected nodes
25
Extracted relationships
100
Concept neighborhoods
13
Bridge connections
25

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 15 topics
Clinical significance · 8 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
FCER2, BLAST-2, CD23, CD23A, CLEC4J, FCE2, IGEBF, Fc fragment of IgE receptor II, FCErII, Fc epsilon receptor II
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4KI1, 1T8C, 1T8D, 2H2R, 2H2T, 4EZM, 4G96, 4G9A, 4GI0, 4GJ0, 4GJX, 4GK1, 4GKO, 4J6J, 4J6K, 4J6L, 4J6M, 4J6N,…
Band
19p13.2 · 8 A1.1|8 1.92 cM
Bgee
testicle · granulocyte · spleen · lymph node · appendix
BioGPS
More reference expression data
Chr.
Chromosome 19 (human) · Chromosome 8 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Clinical significance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How CD23 connects Entity context

The extracted context around CD23 shows recurring relationship patterns in the source. For example, CD23 → carbohydrate binding, cytokine-mediated signaling pathway, external side of plasma membrane, extracellular exosome, extracellular region, IgE binding, integral component of membrane, integral component of plasma membrane, integrin binding, membrane, metal ion binding, Notch signaling pathway, plasma membrane, positive regulation of humoral immune response mediated by circulating immunoglobulin, positive regulation of killing of cells of other organism, positive regulation of nitric-oxide synthase activity, positive regulation of nitric-oxide synthase biosynthetic process, protein binding Another extracted example is CD23 → appendix, blood, bone marrow cell, embryo, granulocyte, lymph node, mesenteric lymph nodes, monocyte, morula, mucosa of transverse colon, spleen, subcutaneous adipose tissue, testicle, thymus, tibiofemoral joint, tonsil, white adipose tissue. Use these groups to spot repeated connection types before inspecting the individual relationships.

CD23

Top relations

Gene ontology · 18
CD23 → carbohydrate binding, cytokine-mediated signaling pathway, external side of plasma membrane, extracellular exosome, extracellular region, IgE binding, integral component of membrane, integral component of plasma membrane, integrin binding, membrane, metal ion binding, Notch signaling pathway, plasma membrane, positive regulation of humoral immune response mediated by circulating immunoglobulin, positive regulation of killing of cells of other organism, positive regulation of nitric-oxide synthase activity, positive regulation of nitric-oxide synthase biosynthetic process, protein binding
Bgee · 17
CD23 → appendix, blood, bone marrow cell, embryo, granulocyte, lymph node, mesenteric lymph nodes, monocyte, morula, mucosa of transverse colon, spleen, subcutaneous adipose tissue, testicle, thymus, tibiofemoral joint, tonsil, white adipose tissue
RNA expression pattern · 17
CD23 → appendix, blood, bone marrow cell, embryo, granulocyte, lymph node, mesenteric lymph nodes, monocyte, morula, mucosa of transverse colon, spleen, subcutaneous adipose tissue, testicle, thymus, tibiofemoral joint, tonsil, white adipose tissue
related to Clinical significance · 16
CD23 → As CD23, B-cell, B-cells, CD23-negative, CD23-positive, Der, Fc, IgE, In, Lymphomas, Paradoxically, Recent, Reed, RI, Sternberg, The
related to Function · 7
CD23 → Antigens, CD11c, CD4, IgE, The, The CD11c, The IgE
Band · 2
CD23 → 19p13.2, 8 A1.1|8 1.92 cM
Chr. · 2
CD23 → Chromosome 19 (human), Chromosome 8 (mouse)
End · 2
CD23 → 3,744,175 bp, 7,702,146 bp
Aliases · 1
CD23 → FCER2, BLAST-2, CD23, CD23A, CLEC4J, FCE2, IGEBF, Fc fragment of IgE receptor II, FCErII, Fc epsilon receptor II
Available structures · 1
CD23 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4KI1, 1T8C, 1T8D, 2H2R, 2H2T, 4EZM, 4G96, 4G9A, 4GI0, 4GJ0, 4GJX, 4GK1, 4GKO, 4J6J, 4J6K, 4J6L, 4J6M, 4J6N,…

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

cells ige human bp chr band antibody chromosome 19 receptor fc epsilon gene location cd23a known follicular fcer2 also external

CD23 relationships Subject–Predicate–Object triples

TTTA extracted 100 structured relationships around CD23. Examples in this analysis include CD23 → Aliases → FCER2, BLAST-2, CD23, CD23A, CLEC4J, FCE2, IGEBF, Fc fragment of IgE receptor II, FCErII, Fc epsilon receptor II and CD23 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4KI1, 1T8C, 1T8D, 2H2R, 2H2T, 4EZM, 4G96, 4G9A, 4GI0, 4GJ0, 4GJX, 4GK1, 4GKO, 4J6J, 4J6K, 4J6L, 4J6M, 4J6N,…. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
CD23AliasesFCER2, BLAST-2, CD23, CD23A, CLEC4J, FCE2, IGEBF, Fc fragment of IgE receptor II, FCErII, Fc epsilon receptor II1.00infobox
CD23Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4KI1, 1T8C, 1T8D, 2H2R, 2H2T, 4EZM, 4G96, 4G9A, 4GI0, 4GJ0, 4GJX, 4GK1, 4GKO, 4J6J, 4J6K, 4J6L, 4J6M, 4J6N,…1.00infobox
CD23Band19p13.21.00infobox
CD23Band8 A1.1|8 1.92 cM1.00infobox
CD23Bgeetesticle1.00infobox
CD23Bgeegranulocyte1.00infobox
CD23Bgeespleen1.00infobox
CD23Bgeelymph node1.00infobox
CD23Bgeeappendix1.00infobox
CD23Bgeeblood1.00infobox
CD23Bgeemonocyte1.00infobox
CD23Bgeemucosa of transverse colon1.00infobox
CD23Bgeebone marrow cell1.00infobox
CD23Bgeetonsil1.00infobox
CD23Bgeemesenteric lymph nodes1.00infobox
CD23Bgeesubcutaneous adipose tissue1.00infobox
CD23Bgeeembryo1.00infobox
CD23Bgeethymus1.00infobox
CD23Bgeetibiofemoral joint1.00infobox
CD23Bgeewhite adipose tissue1.00infobox
CD23Bgeemorula1.00infobox
CD23BioGPSMore reference expression data1.00infobox
CD23Chr.Chromosome 19 (human)1.00infobox
CD23Chr.Chromosome 8 (mouse)1.00infobox
CD23DatabasesNCBI: entry; OMA: entry1.00infobox
CD23End7,702,146 bp1.00infobox
CD23End3,744,175 bp1.00infobox
CD23EnsemblENSG000001049211.00infobox
CD23Entrez22081.00infobox
CD23External IDsOMIM: 151445; MGI: 95497; GeneCards: FCER21.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around CD23 bring nearby vocabulary together. In this analysis, examples include Cells, Ige and Known. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • CD23
    • Cells
    • Ige
    • Known
    • Cell
    • Mantle
    • Positive
    • Antibody
    • Epsilon
    • Fc
    • Receptor
    • Allergy
    • External
  • cd23
    • Cells
    • Ige
    • Known
    • Cell
    • Mantle
    • Positive
    • Antibody
    • Epsilon
    • Fc
    • Receptor
    • Allergy
    • External
  • antibody
    • Regulation
    • Known
    • Ige
    • Allergy
    • End
    • External
    • Function
    • Levels
    • Mouse
    • Present
    • Search
    • Cd23
  • b cells
    • Expressed
    • Follicular
    • Dendritic
    • Eosinophils
    • Macrophages
    • Present
    • Cell
    • Positive
    • Antigen
    • Ige
    • Cd23b
    • End
  • follicular dendritic cells
    • Dendritic
    • Follicular
    • Macrophages
    • Expressed
    • Eosinophils
    • Cd23b
    • Present
    • Cd23a
    • Cell
    • Positive
    • Antigen
    • Ige
  • langerhans cells
    • Expressed
    • Follicular
    • Dendritic
    • Eosinophils
    • Macrophages
    • Present
    • Cell
    • Positive
    • Antigen
    • Ige
    • Cd23b
    • End
  • reed–sternberg cells
    • Expressed
    • Follicular
    • Dendritic
    • Eosinophils
    • Macrophages
    • Present
    • Cell
    • Positive
    • Antigen
    • Ige
    • Cd23b
    • End
  • ige
    • Known
    • Receptor
    • External
    • Function
    • Levels
    • Regulation
    • Search
    • Cell
    • Fcer2
    • Antigen
    • Chromosome
    • Gene

Connections between topic areas Semantic bridges

For CD23, one of the stronger structural bridges in this analysis connects CD23 with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
CD23Overview · splits 10 ⟂ 16
CD23Clinical significance · splits 17 ⟂ 9

Map overview Semantic statistics

CD23

Nodes26
Edges25
Triples100
Avg. degree1.92
Density0.076923
Components1

Source & methodology

TTTA analyzes the structure around CD23 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Standards, Clinical significance & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — CD23 · EN edition · Analysis: TopicsToTalkAbout

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