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Dextropropoxyphene

Dextropropoxyphene is an opioid analgesic patented in 1955 and manufactured by Eli Lilly and Company. It is an optical isomer of levopropoxyphene. It is intended to treat mild pain and also has antitussive (cough suppressant) and local anesthetic effects. The drug has been taken off the market in Europe and the United States due to concerns of fatal…

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3D model (JSmol)
Interactive image
Addiction liability
Low[failed verification]
AHFS/Drugs.com
Monograph
ATC code
N02AC04 (WHO)
Bioavailability
40%
CAS Number
469-62-5 Y

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Overview

Medical uses

Side effects

Pharmacology

Toxicity

History

Society and culture

Drug testing

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Dextropropoxyphene

Nodes90
Edges89
Triples69
Avg. degree1.98
Density0.022222
Components1

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Dextropropoxyphene

Top relations

related to Available forms · 11
Dextropropoxyphene → Balacet, Because, Before, Darvocet, FDA-directed, HCl, Napsylate, Propoxyphene, Shortly, The, United States
Legal status · 7
Dextropropoxyphene → AU: S4 (Prescription only), BR: Class A2 (Narcotic drugs), CA: Schedule I, DE: Anlage II (Authorized trade only, not prescriptible), NZ: Withdrawn (illegal), UK: Class C, US: Schedule II and Schedule IV (when in dosage form)
related to Toxicity · 6
Dextropropoxyphene → An, CNS, Excessive, In, It, Overdose
related to Drug testing · 4
Dextropropoxyphene → Detectable, It, OPI, Propoxyphene
related to Pharmacology · 3
Dextropropoxyphene → It, Morphine, Propoxyphene
related to Usage controversy and regulation · 3
Dextropropoxyphene → Attention, Caution, In
related to Analgesia · 2
Dextropropoxyphene → However, Like
related to history · 2
Dextropropoxyphene → CIA-funded, US Navy
3D model (JSmol) · 1
Dextropropoxyphene → Interactive image
Addiction liability · 1
Dextropropoxyphene → Low[failed verification]

Important terminology Word statistics

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Important terminology

propoxyphene paracetamol effects drug patients co-proxamol available opioid alcohol also darvon may withdrawal market anesthetic withdrawn overdose depression pain toxicity

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Dextropropoxyphene3D model (JSmol)Interactive image1.00infobox
DextropropoxypheneAddiction liabilityLow[failed verification]1.00infobox
DextropropoxypheneAHFS/Drugs.comMonograph1.00infobox
DextropropoxypheneATC codeN02AC04 (WHO)1.00infobox
DextropropoxypheneBioavailability40%1.00infobox
DextropropoxypheneCAS Number469-62-5 Y1.00infobox
DextropropoxypheneChEBICHEBI:51173 Y1.00infobox
DextropropoxypheneChEMBLChEMBL1213351 Y1.00infobox
DextropropoxypheneChemSpider9696 Y1.00infobox
DextropropoxypheneCompTox Dashboard (EPA)DTXSID10235241.00infobox
DextropropoxypheneDrug classOpioid1.00infobox
DextropropoxypheneDrugBankDB00647 N1.00infobox
DextropropoxypheneECHA InfoCard100.006.7471.00infobox
DextropropoxypheneElimination half-life6–12 hours; 30–36 hours (active metabolite, nordextropropoxyphene)1.00infobox
DextropropoxypheneExcretionUrine (major), breastmilk (minor)1.00infobox
DextropropoxypheneFormulaC22H29NO21.00infobox
DextropropoxypheneIUPHAR/BPS75931.00infobox
DextropropoxypheneKEGGD07809 Y1.00infobox
DextropropoxypheneLegal statusAU: S4 (Prescription only)1.00infobox
DextropropoxypheneLegal statusBR: Class A2 (Narcotic drugs)1.00infobox
DextropropoxypheneLegal statusCA: Schedule I1.00infobox
DextropropoxypheneLegal statusDE: Anlage II (Authorized trade only, not prescriptible)1.00infobox
DextropropoxypheneLegal statusNZ: Withdrawn (illegal)1.00infobox
DextropropoxypheneLegal statusUK: Class C1.00infobox
DextropropoxypheneLegal statusUS: Schedule II and Schedule IV (when in dosage form)1.00infobox
DextropropoxypheneLicense dataUS FDA: Propoxyphene1.00infobox
DextropropoxypheneMedlinePlusa6823251.00infobox
DextropropoxypheneMelting point75 °C (167 °F)1.00infobox
DextropropoxypheneMetabolismLiver-mediated, CYP3A4-mediated N-demethylation (major), aromatic hydroxylation (minor) and ester hydrolysis (minor)1.00infobox
DextropropoxypheneMolar mass339.479 g·mol−11.00infobox

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