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CSRP3: Research, Protein interactions and localization & Clinical significance

Cysteine and glycine-rich protein 3 also known as cardiac LIM protein (CLP) or muscle LIM protein (MLP) is a protein that in humans is encoded by the CSRP3 gene.

Language: English [EN]
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CSRP3 topic overview

The analysis highlights Research, Protein interactions and localization and Clinical significance as prominent areas in the source structure around CSRP3.

Related topics
76
Source areas
8
Connected nodes
84
Extracted relationships
149
Concept neighborhoods
26
Bridge connections
84

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Protein interactions and localization · 20 topics
Clinical significance · 14 topics
Function · 12 topics
Animal models · 11 topics
Structure · 8 topics
Overview · 5 topics
Animal studies · 3 topics
Gene · 3 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
CSRP3, CLP, CMD1M, CMH12, CRP3, LMO4, MLP, cysteine and glycine rich protein 3
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2O10, 2O13
Band
11p15.1 · 7|7 B4
Bgee
Skeletal muscle tissue of rectus abdominis · right ventricle · myocardium of left ventricle · apex of heart · biceps brachii
BioGPS
More reference expression data
Chr.
Chromosome 11 (human) · Chromosome 7 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Gene

Structure

Protein interactions and localization

Function

Animal studies

Clinical significance

Animal models

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How CSRP3 connects Entity context

The extracted context around CSRP3 shows recurring relationship patterns in the source. For example, CSRP3 → actin binding, actin cytoskeleton organization, actinin binding, cardiac muscle contraction, cardiac muscle hypertrophy, cardiac muscle tissue development, cardiac myofibril assembly, cell differentiation, cellular calcium ion homeostasis, cytoplasm, cytoskeleton, detection of muscle stretch, development of the heart, glucose homeostasis, identical protein binding, inflammatory response, insulin receptor signaling pathway, metal ion binding, multicellular organism development, muscle organ development Another extracted example is CSRP3 → Alterations, Biochemical, C58G, DCM, Duchenne, For, G72R, HCM, K42/fs165, K69L, K69R, L44P, MLP, MLP-b, MLP/T-cap, MLP/α-actinin, Moreover, Mutations, Q91L, R64C. Use these groups to spot repeated connection types before inspecting the individual relationships.

CSRP3

Top relations

Gene ontology · 41
CSRP3 → actin binding, actin cytoskeleton organization, actinin binding, cardiac muscle contraction, cardiac muscle hypertrophy, cardiac muscle tissue development, cardiac myofibril assembly, cell differentiation, cellular calcium ion homeostasis, cytoplasm, cytoskeleton, detection of muscle stretch, development of the heart, glucose homeostasis, identical protein binding, inflammatory response, insulin receptor signaling pathway, metal ion binding, multicellular organism development, muscle organ development
related to Clinical significance · 27
CSRP3 → Alterations, Biochemical, C58G, DCM, Duchenne, For, G72R, HCM, K42/fs165, K69L, K69R, L44P, MLP, MLP-b, MLP/T-cap, MLP/α-actinin, Moreover, Mutations, Q91L, R64C
Bgee · 19
CSRP3 → ankle, apex of heart, atrioventricular valve, atrium, biceps brachii, cardiac muscle tissue of right atrium, cardiac muscles, endocardial cushion, esophagus, glutes, interventricular septum, myocardium of left ventricle, myocardium of ventricle, right auricle of heart, right ventricle, Skeletal muscle tissue of biceps brachii, Skeletal muscle tissue of rectus abdominis, soleus muscle, thoracic diaphragm
RNA expression pattern · 19
CSRP3 → ankle, apex of heart, atrioventricular valve, atrium, biceps brachii, cardiac muscle tissue of right atrium, cardiac muscles, endocardial cushion, esophagus, glutes, interventricular septum, myocardium of left ventricle, myocardium of ventricle, right auricle of heart, right ventricle, Skeletal muscle tissue of biceps brachii, Skeletal muscle tissue of rectus abdominis, soleus muscle, thoracic diaphragm
related to External links · 11
CSRP3 → Cysteine, Familial Hypertrophic Cardiomyopathy OverviewHuman, GeneReviews/NIH/NCBI/UW, Human LMO4, LMO4, Overview, P50461, PDB, PDBe-KB, UCSC Genome Browser, UniProt
related to Gene · 4
CSRP3 → In, MLP-b, The, The CSRP3
Band · 2
CSRP3 → 11p15.1, 7|7 B4
Chr. · 2
CSRP3 → Chromosome 11 (human), Chromosome 7 (mouse)
End · 2
CSRP3 → 19,210,571 bp, 48,497,781 bp
Aliases · 1
CSRP3 → CSRP3, CLP, CMD1M, CMH12, CRP3, LMO4, MLP, cysteine and glycine rich protein 3

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

mlp protein gene muscle localization human cardiac bp function expressed chr band also chromosome location z-line cardiomyopathy 11 cytoskeleton nucleus

CSRP3 relationships Subject–Predicate–Object triples

TTTA extracted 149 structured relationships around CSRP3. Examples in this analysis include CSRP3 → Aliases → CSRP3, CLP, CMD1M, CMH12, CRP3, LMO4, MLP, cysteine and glycine rich protein 3 and CSRP3 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2O10, 2O13. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
CSRP3AliasesCSRP3, CLP, CMD1M, CMH12, CRP3, LMO4, MLP, cysteine and glycine rich protein 31.00infobox
CSRP3Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2O10, 2O131.00infobox
CSRP3Band11p15.11.00infobox
CSRP3Band7|7 B41.00infobox
CSRP3BgeeSkeletal muscle tissue of rectus abdominis1.00infobox
CSRP3Bgeeright ventricle1.00infobox
CSRP3Bgeemyocardium of left ventricle1.00infobox
CSRP3Bgeeapex of heart1.00infobox
CSRP3Bgeebiceps brachii1.00infobox
CSRP3BgeeSkeletal muscle tissue of biceps brachii1.00infobox
CSRP3Bgeethoracic diaphragm1.00infobox
CSRP3Bgeeglutes1.00infobox
CSRP3Bgeecardiac muscle tissue of right atrium1.00infobox
CSRP3Bgeeright auricle of heart1.00infobox
CSRP3Bgeeatrioventricular valve1.00infobox
CSRP3Bgeeendocardial cushion1.00infobox
CSRP3Bgeeinterventricular septum1.00infobox
CSRP3Bgeecardiac muscles1.00infobox
CSRP3Bgeemyocardium of ventricle1.00infobox
CSRP3Bgeeankle1.00infobox
CSRP3Bgeeatrium1.00infobox
CSRP3Bgeeesophagus1.00infobox
CSRP3Bgeesoleus muscle1.00infobox
CSRP3BioGPSMore reference expression data1.00infobox
CSRP3Chr.Chromosome 11 (human)1.00infobox
CSRP3Chr.Chromosome 7 (mouse)1.00infobox
CSRP3DatabasesNCBI: entry; OMA: entry1.00infobox
CSRP3End19,210,571 bp1.00infobox
CSRP3End48,497,781 bp1.00infobox
CSRP3EnsemblENSG000001291701.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around CSRP3 bring nearby vocabulary together. In this analysis, examples include Gene, Expressed and Location. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • CSRP3
    • Gene
    • Expressed
    • Location
    • Protein
    • Cysteine
    • Human
    • Skeletal
    • Muscle
    • Bp
    • Cardiomyopathy
    • Chr
    • Chromosome
  • csrp3
    • Gene
    • Expressed
    • Location
    • Protein
    • Cysteine
    • Human
    • Skeletal
    • Muscle
    • Bp
    • Cardiomyopathy
    • Chr
    • Chromosome
  • protein
    • Skeletal
    • Well
    • Z-line
    • Localization
    • Human
    • Costameres
    • Cytoskeleton
    • Nucleus
    • Bp
    • Chr
    • Chromosome
    • Heart
  • gene
    • Location
    • Human
    • Mouse
    • Bp
    • Chr
    • Chromosome
    • Band
    • Localization
    • Cardiomyopathy
    • Heart
    • Protein
    • Function
  • skeletal
    • Cardiac
    • Expressed
    • Heart
    • Muscle
    • Csrp3
    • Protein
    • Human
    • Actin
    • Band
    • Calcium
    • Cellular
    • Cytoskeleton
  • cardiac muscle
    • Heart
    • Skeletal
    • Failure
    • Muscle
    • Csrp3
    • Function
    • Protein
    • Striated
    • Gene
    • Human
    • Mouse
    • Alterations
  • scaffold protein
    • Skeletal
    • Well
    • Z-line
    • Localization
    • Human
    • Costameres
    • Cytoskeleton
    • Nucleus
    • Bp
    • Chr
    • Chromosome
    • Heart
  • actin
    • Cytoskeleton
    • Expressed
    • Skeletal
    • Band
    • Calcium
    • Cellular
    • Implicated
    • Interaction
    • Mouse
    • Nucleus
    • Bp
    • Chr

Connections between topic areas Semantic bridges

For CSRP3, one of the stronger structural bridges in this analysis connects CSRP3 with Protein interactions and localization. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
CSRP3Protein interactions and localization · splits 64 ⟂ 21
CSRP3Clinical significance · splits 70 ⟂ 15
CSRP3Function · splits 72 ⟂ 13
CSRP3Animal models · splits 73 ⟂ 12
CSRP3Structure · splits 76 ⟂ 9
CSRP3Overview · splits 79 ⟂ 6
CSRP3Gene · splits 81 ⟂ 4
CSRP3Animal studies · splits 81 ⟂ 4

Map overview Semantic statistics

CSRP3

Nodes85
Edges84
Triples149
Avg. degree1.98
Density0.023529
Components1

Source & methodology

TTTA analyzes the structure around CSRP3 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Research, Protein interactions and localization & Clinical significance, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — CSRP3 · EN edition · Analysis: TopicsToTalkAbout

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