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Nebulin: Overview, Knockout phenotype & Structure

Nebulin is an actin-binding protein which is localized to the thin filament of the sarcomeres in skeletal muscle. Nebulin in humans is coded for by the gene NEB. It is a very large protein (600–900 kDa) and binds as many as 200 actin monomers. Because its length is proportional to thin filament length, it is believed that nebulin acts as a thin filament…

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Nebulin topic overview

The analysis highlights Overview, Knockout phenotype and Structure as prominent areas in the source structure around Nebulin.

Related topics
21
Source areas
3
Connected nodes
24
Extracted relationships
96
Concept neighborhoods
12
Bridge connections
24

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 14 topics
Knockout phenotype · 4 topics
Structure · 3 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
NEB, nebulin, NEB177D, NEM2, AMC6
Available structures
Available structuresPDBHuman UniProt search: PDBe RCSB List of PDB id codes1NEB, 1ARK
Band
2q23.3 · 2 C1.1|2 29.98 cM
Bgee
glutes · biceps brachii · Skeletal muscle tissue of biceps brachii · tibialis anterior muscle · Skeletal muscle tissue of rectus abdominis
BioGPS
n/a
Chr.
Chromosome 2 (human) · Chromosome 2 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure

Knockout phenotype

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Nebulin connects Entity context

The extracted context around Nebulin shows recurring relationship patterns in the source. For example, Nebulin → biceps brachii, deltoid muscle, gastrocnemius muscle, glutes, knee joint, medial head of gastrocnemius muscle, muscle of thigh, quadriceps femoris muscle, skeletal muscle tissue, Skeletal muscle tissue of biceps brachii, Skeletal muscle tissue of rectus abdominis, soleus muscle, temporal muscle, tibialis anterior muscle, triceps brachii muscle, vastus lateralis muscle Another extracted example is Nebulin → actin binding, actin cytoskeleton, actin filament binding, cardiac muscle thin filament assembly, cytoplasm, cytoskeleton, cytosol, extracellular exosome, muscle filament sliding, muscle organ development, protein binding, regulation of actin filament length, sarcomere, somatic muscle development, structural constituent of muscle, Z discdkac. Use these groups to spot repeated connection types before inspecting the individual relationships.

Nebulin

Top relations

Bgee · 16
Nebulin → biceps brachii, deltoid muscle, gastrocnemius muscle, glutes, knee joint, medial head of gastrocnemius muscle, muscle of thigh, quadriceps femoris muscle, skeletal muscle tissue, Skeletal muscle tissue of biceps brachii, Skeletal muscle tissue of rectus abdominis, soleus muscle, temporal muscle, tibialis anterior muscle, triceps brachii muscle, vastus lateralis muscle
Gene ontology · 16
Nebulin → actin binding, actin cytoskeleton, actin filament binding, cardiac muscle thin filament assembly, cytoplasm, cytoskeleton, cytosol, extracellular exosome, muscle filament sliding, muscle organ development, protein binding, regulation of actin filament length, sarcomere, somatic muscle development, structural constituent of muscle, Z discdkac
RNA expression pattern · 16
Nebulin → biceps brachii, deltoid muscle, gastrocnemius muscle, glutes, knee joint, medial head of gastrocnemius muscle, muscle of thigh, quadriceps femoris muscle, skeletal muscle tissue, Skeletal muscle tissue of biceps brachii, Skeletal muscle tissue of rectus abdominis, soleus muscle, temporal muscle, tibialis anterior muscle, triceps brachii muscle, vastus lateralis muscle
related to Further reading · 8
Nebulin → Björklund AK, Elofsson, Journal, Light, Molecular Biology, PMID, Sagit, September
related to External links · 7
Nebulin → GeneReviews/NCBI/NIH/UW, Human Nebulin, Medicine Medical Subject Headings, MeSH, National Library, Nemaline MyopathyPDBe-KB, PDB
related to Knockout phenotype · 5
Nebulin → As, Bang, Postnatal, These, Witt
related to Structure · 3
Nebulin → SH3, The, The SH3
Band · 2
Nebulin → 2 C1.1|2 29.98 cM, 2q23.3
Chr. · 2
Nebulin → Chromosome 2 (human), Chromosome 2 (mouse)
End · 2
Nebulin → 151,734,487 bp, 52,378,474 bp

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

protein bp human thin filament chr band gene chromosome neb length muscle sarcomere structure mouse function location mice nemaline myopathy

Nebulin relationships Subject–Predicate–Object triples

TTTA extracted 96 structured relationships around Nebulin. Examples in this analysis include Nebulin → Aliases → NEB, nebulin, NEB177D, NEM2, AMC6 and Nebulin → Available structures → Available structuresPDBHuman UniProt search: PDBe RCSB List of PDB id codes1NEB, 1ARK. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
NebulinAliasesNEB, nebulin, NEB177D, NEM2, AMC61.00infobox
NebulinAvailable structuresAvailable structuresPDBHuman UniProt search: PDBe RCSB List of PDB id codes1NEB, 1ARK1.00infobox
NebulinBand2q23.31.00infobox
NebulinBand2 C1.1|2 29.98 cM1.00infobox
NebulinBgeeglutes1.00infobox
NebulinBgeebiceps brachii1.00infobox
NebulinBgeeSkeletal muscle tissue of biceps brachii1.00infobox
NebulinBgeetibialis anterior muscle1.00infobox
NebulinBgeeSkeletal muscle tissue of rectus abdominis1.00infobox
NebulinBgeegastrocnemius muscle1.00infobox
NebulinBgeedeltoid muscle1.00infobox
NebulinBgeetriceps brachii muscle1.00infobox
NebulinBgeequadriceps femoris muscle1.00infobox
NebulinBgeevastus lateralis muscle1.00infobox
NebulinBgeemuscle of thigh1.00infobox
NebulinBgeeknee joint1.00infobox
NebulinBgeesoleus muscle1.00infobox
NebulinBgeemedial head of gastrocnemius muscle1.00infobox
NebulinBgeeskeletal muscle tissue1.00infobox
NebulinBgeetemporal muscle1.00infobox
NebulinBioGPSn/a1.00infobox
NebulinChr.Chromosome 2 (human)1.00infobox
NebulinChr.Chromosome 2 (mouse)1.00infobox
NebulinDatabasesNCBI: entry; OMA: entry1.00infobox
NebulinEnd151,734,487 bp1.00infobox
NebulinEnd52,378,474 bp1.00infobox
NebulinEnsemblENSG000001830911.00infobox
NebulinEntrez47031.00infobox
NebulinExternal IDsOMIM: 161650; MGI: 97292; GeneCards: NEB1.00infobox
NebulinGene location (Human)Gene location (Human)Chr.Chromosome 2 (human)Band2q23.3Start151,485,336 bpEnd151,734,487 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Nebulin bring nearby vocabulary together. In this analysis, examples include Structure, Protein and Muscle. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Nebulin
    • Structure
    • Protein
    • Muscle
    • Neb
    • Sarcomere
    • Gene
    • Filament
    • Human
    • Thin
    • Assembly
    • Cardiac
    • Expressed
  • nebulin
    • Structure
    • Protein
    • Muscle
    • Neb
    • Sarcomere
    • Gene
    • Filament
    • Human
    • Thin
    • Assembly
    • Cardiac
    • Expressed
  • thin filament
    • Thin
    • Length
    • Function
    • Assembly
    • Skeletal
    • Muscle
    • Sarcomere
    • Mice
    • Protein
    • Nebulin
    • Actin
    • Also
  • skeletal muscle
    • Cardiac
    • Expressed
    • Skeletal
    • Protein
    • Thin
    • Actin
    • Assembly
    • C1
    • End
    • Search
    • Uniprot
    • Location
  • gene
    • Location
    • Neb
    • Chromosome
    • Bp
    • C1
    • Chr
    • End
    • Human
    • Search
    • Uniprot
    • Mouse
    • Band
  • cardiac muscle
    • Expressed
    • Cardiac
    • Muscle
    • Skeletal
    • Protein
    • C1
    • End
    • Search
    • Thin
    • Uniprot
    • Actin
    • Assembly
  • protein nuclear magnetic resonance spectroscopy
    • Actin
    • Cardiac
    • Expressed
    • Skeletal
    • Thin
    • Assembly
    • C1
    • End
    • Search
    • Uniprot
    • Location
    • Mouse
  • sarcomere
    • Thin
    • C1
    • Cardiac
    • End
    • Expressed
    • Search
    • Skeletal
    • Uniprot
    • Location
    • Mouse
    • Band
    • Chromosome

Connections between topic areas Semantic bridges

For Nebulin, one of the stronger structural bridges in this analysis connects Nebulin with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
NebulinOverview · splits 10 ⟂ 15
NebulinKnockout phenotype · splits 20 ⟂ 5
NebulinStructure · splits 21 ⟂ 4

Map overview Semantic statistics

Nebulin

Nodes25
Edges24
Triples96
Avg. degree1.92
Density0.08
Components1

Source & methodology

TTTA analyzes the structure around Nebulin to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Overview, Knockout phenotype & Structure, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Nebulin · EN edition · Analysis: TopicsToTalkAbout

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