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Rofecoxib: Art & Measurement

Rofecoxib is a COX-2-selective nonsteroidal anti-inflammatory drug (NSAID). It was marketed by Merck & Co. to treat osteoarthritis, rheumatoid arthritis, juvenile rheumatoid arthritis, acute pain conditions, migraine, and dysmenorrhea. Rofecoxib was approved in the United States by the Food and Drug Administration (FDA) in May 1999, and was marketed…

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Rofecoxib topic overview

The analysis highlights Art and Measurement as prominent areas in the source structure around Rofecoxib.

Related topics
57
Source areas
6
Connected nodes
63
Extracted relationships
106
Concept neighborhoods
11
Bridge connections
63

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 27 topics
Litigation · 16 topics
Withdrawal · 6 topics
Mode of action · 4 topics
Efficacy · 3 topics
Possible return to market · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
Interactive image
ATC code
M01AH02 (WHO)
Bioavailability
93%
CAS Number
162011-90-7 Y
ChEBI
CHEBI:8887 Y
ChEMBL
ChEMBL122 Y

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Mode of action

Efficacy

Withdrawal

Litigation

Possible return to market

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Rofecoxib connects Entity context

The extracted context around Rofecoxib shows recurring relationship patterns in the source. For example, Rofecoxib → Alabama, Atlantic City, By March, Carol Ernst, Humeston, Humeston's, Merck, Merck's, New Jersey, On August, On November, Robert Ernst, Rogers, Texas, The, This, US Another extracted example is Rofecoxib → American, Canada, Canadian, COX-2, Despite, FDA, FDA Advisory Committee, Following, In, Merck, NSAIDs, The, The FDA. Use these groups to spot repeated connection types before inspecting the individual relationships.

Rofecoxib

Top relations

related to Litigation · 17
Rofecoxib → Alabama, Atlantic City, By March, Carol Ernst, Humeston, Humeston's, Merck, Merck's, New Jersey, On August, On November, Robert Ernst, Rogers, Texas, The, This, US
related to FDA position · 13
Rofecoxib → American, Canada, Canadian, COX-2, Despite, FDA, FDA Advisory Committee, Following, In, Merck, NSAIDs, The, The FDA
related to Possible return to market · 13
Rofecoxib → COX-2, FDA, HA, In March, In November, It, Massachusetts-based Tremeau Pharmaceuticals, Merck, Traditional NSAIDs, Tremeau, TRM-201, United States, VIOXX
related to Mode of action · 11
Rofecoxib → Arcoxia, Bextra, By, Celebrex, COX, COX-1, COX-2, Cyclooxygenase, NSAIDs, Though, Vioxx
related to Withdrawal · 11
Rofecoxib → Americans, APPROVe, As, FDA, Furthermore, In, Merck, One FDA, Senior FDA, September, Vioxx
has effect · 3
Rofecoxib → Aside, In, NSAIDs
is a · 2
Rofecoxib → COX-2-selective nonsteroidal anti-inflammatory drug, selective COX-2 inhibitor
related to Efficacy · 2
Rofecoxib → FDA, When
3D model (JSmol) · 1
Rofecoxib → Interactive image
ATC code · 1
Rofecoxib → M01AH02 (WHO)

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

merck risk vioxx cardiovascular heart fda study nsaids cox-2 events data drug patients trial 2005 increased selective states studies market

Rofecoxib relationships Subject–Predicate–Object triples

TTTA extracted 106 structured relationships around Rofecoxib. Examples in this analysis include Rofecoxib → 3D model (JSmol) → Interactive image and Rofecoxib → ATC code → M01AH02 (WHO). The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Rofecoxib3D model (JSmol)Interactive image1.00infobox
RofecoxibATC codeM01AH02 (WHO)1.00infobox
RofecoxibBioavailability93%1.00infobox
RofecoxibCAS Number162011-90-7 Y1.00infobox
RofecoxibChEBICHEBI:8887 Y1.00infobox
RofecoxibChEMBLChEMBL122 Y1.00infobox
RofecoxibChemSpider4911 Y1.00infobox
RofecoxibCompTox Dashboard (EPA)DTXSID20235671.00infobox
RofecoxibDrugBankDB00533 Y1.00infobox
RofecoxibECHA InfoCard100.230.0771.00infobox
RofecoxibElimination half-life17 hours1.00infobox
RofecoxibExcretionbile duct/kidney1.00infobox
RofecoxibFormulaC17H14O4S1.00infobox
RofecoxibIUPHAR/BPS28931.00infobox
RofecoxibKEGGD00568 Y1.00infobox
RofecoxibLegal statuswithdrawn worldwide1.00infobox
RofecoxibMetabolismliver1.00infobox
RofecoxibMolar mass314.36 g·mol−11.00infobox
RofecoxibPregnancy categoryAU: C1.00infobox
RofecoxibPronunciation/ˌrɒfɪˈkɒksɪb/1.00infobox
RofecoxibProtein binding87%1.00infobox
RofecoxibPubChem CID50901.00infobox
RofecoxibRoutes of administrationBy mouth & i.m1.00infobox
RofecoxibTrade namesVioxx, Ceoxx, Ceeoxx, others1.00infobox
RofecoxibUNII0QTW8Z7MCR1.00infobox
Rofecoxibis aCOX-2-selective nonsteroidal anti-inflammatory drug0.90text
Rofecoxibis aselective COX-2 inhibitor0.90text

Related concept clusters Concept neighborhoods

The concept neighborhoods around Rofecoxib bring nearby vocabulary together. In this analysis, examples include Risk, Cardiovascular and Fda. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Rofecoxib
    • Risk
    • Cardiovascular
    • Fda
    • Study
    • Events
    • Cox-2
    • Nsaids
    • Announced
    • Compared
    • Market
    • Adverse
    • Studies
  • rofecoxib
    • Risk
    • Cardiovascular
    • Fda
    • Study
    • Events
    • Cox-2
    • Nsaids
    • Announced
    • Compared
    • Market
    • Adverse
    • Studies
  • nonsteroidal anti-inflammatory drug
    • Heart
    • Vioxx
    • Merck
    • United
    • Market
    • States
    • Fda
    • Celecoxib
    • Disease
    • Pain
    • Attacks
    • Found
  • merck & co.
    • Vioxx
    • Heart
    • Rofecoxib
    • Study
    • Risk
    • Attack
    • Studies
    • Trial
    • Vigor
    • Events
    • Announced
    • Cardiovascular
  • food and drug administration
    • Heart
    • Vioxx
    • Merck
    • United
    • Market
    • States
    • Fda
    • Celecoxib
    • Disease
    • Pain
    • Attacks
    • Found
  • cardiovascular
    • Events
    • Risk
    • Adverse
    • Increased
    • Study
    • Cox-2
    • Months
    • Data
    • Nsaids
    • Rofecoxib
    • Fda
    • Serious
  • celecoxib
    • Selective
    • Cox-2
    • Compared
    • United
    • States
    • Drug
    • Data
    • Nsaids
    • Serious
    • Pain
    • Found
    • Relative
  • possible return to market
    • Announced
    • Heart
    • Ha
    • Treatment
    • Rofecoxib
    • Cox-2
    • Risk
    • Study
    • Disease
    • Merck
    • Attacks
    • Found

Connections between topic areas Semantic bridges

For Rofecoxib, one of the stronger structural bridges in this analysis connects Rofecoxib with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Rofecoxib — Overview · splits 36 ⟂ 28
Rofecoxib — Litigation · splits 47 ⟂ 17
Rofecoxib — Withdrawal · splits 57 ⟂ 7
Rofecoxib — Mode of action · splits 59 ⟂ 5
Rofecoxib — Efficacy · splits 60 ⟂ 4

Map overview Semantic statistics

Rofecoxib

Nodes64
Edges63
Triples106
Avg. degree1.97
Density0.03125
Components1

Source & methodology

TTTA analyzes the structure around Rofecoxib to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Art & Measurement, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Rofecoxib · EN edition · Analysis: TopicsToTalkAbout

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