Rofecoxib

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Rofecoxib topic overview

The analysis highlights Art and Measurement as prominent areas in the source structure around Rofecoxib.

Related topics: 55
Source areas: 5
Connected nodes: 61
Extracted relationships: 95
Related term clusters: 11
Bridge connections: 61

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 27 topics

Litigation · 15 topics

Withdrawal · 6 topics

Mode of action · 4 topics

Efficacy · 3 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol): Interactive image
ATC code: M01AH02 (WHO)
Bioavailability: 93%
CAS Number: 162011-90-7 Y
ChEBI: CHEBI:8887 Y
ChEMBL: ChEMBL122 Y

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Rofecoxib

8COX-2 inhibitor · Nonsteroidal anti-inflammatory drug · Merck & Co.

27Myocardial infarction · Stroke · Hemophilic arthropathy

4Houston · Hung jury · New Orleans

3John S. Martin Jr. · United States District Court for the Southern District of New York · Debevoise & Plimpton

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Mode of action

Efficacy

Withdrawal

Litigation

For the semantics nerds

You can skip this section if you’re here for content ideas and keyword inspiration.

Advanced semantic analysis

How Rofecoxib connects Entity context

The extracted context around Rofecoxib shows recurring relationship patterns in the source. For example, Rofecoxib → Alabama, Atlantic City, By March, Carol Ernst, Humeston, Humeston's, Merck, Merck's, New Jersey, On August, On November, Robert Ernst, Rogers, Texas, US Another extracted example is Rofecoxib → COX-2, FDA, HA, In March, In November, Massachusetts-based Tremeau Pharmaceuticals, Merck, Traditional NSAIDs, Tremeau, TRM-201, United States, VIOXX. Use these groups to spot repeated connection types before inspecting the individual relationships.

Top relations

related to Litigation · 15

Rofecoxib → Alabama, Atlantic City, By March, Carol Ernst, Humeston, Humeston's, Merck, Merck's, New Jersey, On August, On November, Robert Ernst, Rogers, Texas, US

related to Possible return to market · 12

Rofecoxib → COX-2, FDA, HA, In March, In November, Massachusetts-based Tremeau Pharmaceuticals, Merck, Traditional NSAIDs, Tremeau, TRM-201, United States, VIOXX

related to FDA position · 11

Rofecoxib → American, Canada, Canadian, COX-2, Despite, FDA, FDA Advisory Committee, Following, Merck, NSAIDs, The FDA

related to Mode of action · 10

Rofecoxib → Arcoxia, Bextra, Celebrex, COX, COX-1, COX-2, Cyclooxygenase, NSAIDs, Though, Vioxx

related to Withdrawal · 9

Rofecoxib → Americans, APPROVe, FDA, Furthermore, Merck, One FDA, Senior FDA, September, Vioxx

is a · 2

Rofecoxib → COX-2-selective nonsteroidal anti-inflammatory drug, selective COX-2 inhibitor

has effect · 2

Rofecoxib → Aside, NSAIDs

3D model (JSmol) · 1

Rofecoxib → Interactive image

ATC code · 1

Rofecoxib → M01AH02 (WHO)

Bioavailability · 1

Rofecoxib → 93%

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

merck risk vioxx cardiovascular heart fda study nsaids cox-2 events data drug patients trial 2005 increased selective states studies market

Rofecoxib relationships Subject–Predicate–Object triples

TTTA extracted 95 structured relationships around Rofecoxib. Examples in this analysis include Rofecoxib → 3D model (JSmol) → Interactive image and Rofecoxib → ATC code → M01AH02 (WHO). The table shows each extracted connection, where it came from and its confidence.

Subject	Predicate	Object	Confidence	Src
Rofecoxib	3D model (JSmol)	Interactive image	1.00	infobox
Rofecoxib	ATC code	M01AH02 (WHO)	1.00	infobox
Rofecoxib	Bioavailability	93%	1.00	infobox
Rofecoxib	CAS Number	162011-90-7 Y	1.00	infobox
Rofecoxib	ChEBI	CHEBI:8887 Y	1.00	infobox
Rofecoxib	ChEMBL	ChEMBL122 Y	1.00	infobox
Rofecoxib	ChemSpider	4911 Y	1.00	infobox
Rofecoxib	CompTox Dashboard (EPA)	DTXSID2023567	1.00	infobox
Rofecoxib	DrugBank	DB00533 Y	1.00	infobox
Rofecoxib	ECHA InfoCard	100.230.077	1.00	infobox
Rofecoxib	Elimination half-life	17 hours	1.00	infobox
Rofecoxib	Excretion	bile duct/kidney	1.00	infobox
Rofecoxib	Formula	C17H14O4S	1.00	infobox
Rofecoxib	IUPHAR/BPS	2893	1.00	infobox
Rofecoxib	KEGG	D00568 Y	1.00	infobox
Rofecoxib	Legal status	withdrawn worldwide	1.00	infobox
Rofecoxib	Metabolism	liver	1.00	infobox
Rofecoxib	Molar mass	314.36 g·mol−1	1.00	infobox
Rofecoxib	Pregnancy category	AU: C	1.00	infobox
Rofecoxib	Pronunciation	/ˌrɒfɪˈkɒksɪb/	1.00	infobox
Rofecoxib	Protein binding	87%	1.00	infobox
Rofecoxib	PubChem CID	5090	1.00	infobox
Rofecoxib	Routes of administration	By mouth & i.m	1.00	infobox
Rofecoxib	Trade names	Vioxx, Ceoxx, Ceeoxx, others	1.00	infobox
Rofecoxib	UNII	0QTW8Z7MCR	1.00	infobox
Rofecoxib	is a	COX-2-selective nonsteroidal anti-inflammatory drug	0.90	text
Rofecoxib	is a	selective COX-2 inhibitor	0.90	text

Related concept clusters Related term clusters

The concept neighborhoods around Rofecoxib bring nearby vocabulary together. In this analysis, examples include Risk, Cardiovascular and Fda. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

Rofecoxib
- Risk
- Cardiovascular
- Fda
- Study
- Events
- Cox-2
- Nsaids
- Announced
- Compared
- Market
- Adverse
- Studies
rofecoxib
- Risk
- Cardiovascular
- Fda
- Study
- Events
- Cox-2
- Nsaids
- Announced
- Compared
- Market
- Adverse
- Studies
nonsteroidal anti-inflammatory drug
- Heart
- Vioxx
- Merck
- United
- Market
- States
- Fda
- Celecoxib
- Disease
- Pain
- Attacks
- Found
merck & co.
- Vioxx
- Heart
- Rofecoxib
- Study
- Risk
- Attack
- Studies
- Trial
- Vigor
- Events
- Announced
- Cardiovascular
food and drug administration
- Heart
- Vioxx
- Merck
- United
- Market
- States
- Fda
- Celecoxib
- Disease
- Pain
- Attacks
- Found
cardiovascular
- Events
- Risk
- Adverse
- Increased
- Study
- Cox-2
- Months
- Data
- Nsaids
- Rofecoxib
- Fda
- Serious
celecoxib
- Selective
- Cox-2
- Compared
- United
- States
- Drug
- Data
- Nsaids
- Serious
- Pain
- Found
- Relative
possible return to market
- Announced
- Heart
- Ha
- Treatment
- Rofecoxib
- Cox-2
- Risk
- Study
- Disease
- Merck
- Attacks
- Found

Connections between topic areas Semantic bridges

For Rofecoxib, one of the stronger structural bridges in this analysis connects Rofecoxib with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

Rofecoxib — Overview · splits 34 ⟂ 28

Rofecoxib — Litigation · splits 46 ⟂ 16

Rofecoxib — Withdrawal · splits 55 ⟂ 7

Rofecoxib — Mode of action · splits 57 ⟂ 5

Rofecoxib — Efficacy · splits 58 ⟂ 4

Map overview Semantic statistics

Rofecoxib

Nodes62

Edges61

Triples95

Avg. degree1.97

Density0.032258

Components1

Source & methodology

TTTA analyzes the structure around Rofecoxib to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Art & Measurement, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Rofecoxib · EN edition · Analysis: TopicsToTalkAbout

Rofecoxib: Art & Measurement

Rofecoxib topic overview

What this topic covers Research coverage

Key facts & relationships

Start with your topic. Discover where to go next.

Questions to explore

Explore all related topics Closing gaps

Overview

Mode of action

Efficacy

Withdrawal

Litigation

For the semantics nerds

Advanced semantic analysis

How Rofecoxib connects Entity context

Rofecoxib

Top relations

Important terminology

Important terminology

Rofecoxib relationships Subject–Predicate–Object triples

Related concept clusters Related term clusters

Connections between topic areas Semantic bridges

Map overview Semantic statistics

Rofecoxib

Source & methodology