Research any topic before you write.

Find related topics. | Discover entities. | See connections. | Build a topical map.

CD200: Expression, Function & Clinical significance

OX-2 membrane glycoprotein, also named CD200 (Cluster of Differentiation 200) is a human protein encoded by the CD200 gene. In humans, the CD200 gene is located on chromosome 3 in proximity to genes encoding the other B7 proteins CD80/CD86. In mice, the CD200 gene is located on chromosome 16.

Language: English [EN]
Use the mouse wheel or two fingers (on touchscreens) to zoom in and out of the map.
100%
More settings
100% 100% 100% 100% 100%

CD200 topic overview

The analysis highlights Expression, Function and Clinical significance as prominent areas in the source structure around CD200.

Related topics
75
Source areas
5
Connected nodes
80
Extracted relationships
178
Concept neighborhoods
31
Bridge connections
80

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Expression · 29 topics
Function · 16 topics
Clinical significance · 12 topics
Mechanism of action · 10 topics
Overview · 8 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
CD200, CD200 molecule, MOX1, MOX2, MRC, OX-2, CD-200
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4BFI
Band
3q13.2 · 16 B5|16 29.53 cM
Bgee
frontal pole · ganglionic eminence · Brodmann area 10 · middle frontal gyrus · hypothalamus
BioGPS
More reference expression data
Chr.
Chromosome 3 (human) · Chromosome 16 (mouse)

Suggested research paths

A focused starting point derived from the topic graph, ranked independently of the source article order.

Start with these areas

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Expression

Function

Mechanism of action

Clinical significance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How CD200 connects Entity context

The extracted context around CD200 shows recurring relationship patterns in the source. For example, CD200 → axon, cell adhesion molecule binding, cell body, cell recognition, cell surface, cell-cell adhesion, glycosylated region protein binding, heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules, heterotypic cell-cell adhesion, homophilic cell adhesion via plasma membrane adhesion molecules, integral component of membrane, integral component of plasma membrane, membrane, negative regulation of cell population proliferation, negative regulation of leukocyte activation, negative regulation of macrophage activation, negative regulation of macrophage migration, negative regulation of matrix metallopeptidase secretion, negative regulation of neuroinflammatory response, negative regulation of neuron death Another extracted example is CD200 → aortic valve, arcuate nucleus, ascending aorta, body of femur, Brodmann area 10, Brodmann area 23, Brodmann area 46, Brodmann area 9, dorsomedial hypothalamic nucleus, frontal pole, ganglionic eminence, hypothalamus, middle frontal gyrus, orbitofrontal cortex, paraventricular nucleus of hypothalamus, parietal pleura, suprachiasmatic nucleus, tunica media of zone of aorta, ventral tegmental area, ventromedial nucleus. Use these groups to spot repeated connection types before inspecting the individual relationships.

CD200

Top relations

Gene ontology · 35
CD200 → axon, cell adhesion molecule binding, cell body, cell recognition, cell surface, cell-cell adhesion, glycosylated region protein binding, heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules, heterotypic cell-cell adhesion, homophilic cell adhesion via plasma membrane adhesion molecules, integral component of membrane, integral component of plasma membrane, membrane, negative regulation of cell population proliferation, negative regulation of leukocyte activation, negative regulation of macrophage activation, negative regulation of macrophage migration, negative regulation of matrix metallopeptidase secretion, negative regulation of neuroinflammatory response, negative regulation of neuron death
Bgee · 20
CD200 → aortic valve, arcuate nucleus, ascending aorta, body of femur, Brodmann area 10, Brodmann area 23, Brodmann area 46, Brodmann area 9, dorsomedial hypothalamic nucleus, frontal pole, ganglionic eminence, hypothalamus, middle frontal gyrus, orbitofrontal cortex, paraventricular nucleus of hypothalamus, parietal pleura, suprachiasmatic nucleus, tunica media of zone of aorta, ventral tegmental area, ventromedial nucleus
RNA expression pattern · 20
CD200 → aortic valve, arcuate nucleus, ascending aorta, body of femur, Brodmann area 10, Brodmann area 23, Brodmann area 46, Brodmann area 9, dorsomedial hypothalamic nucleus, frontal pole, ganglionic eminence, hypothalamus, middle frontal gyrus, orbitofrontal cortex, paraventricular nucleus of hypothalamus, parietal pleura, suprachiasmatic nucleus, tunica media of zone of aorta, ventral tegmental area, ventromedial nucleus
related to External links · 15
CD200 → Antigen, Human CD200, Medicine, Medicine Medical Subject Headings, MeSH, Mouse OX-2, National Library, O54901, Overview, PDB, PDBe-KB, This, UCSC Genome Browser, UniProt, United States National Library
related to Function · 13
CD200 → CD200-CD200R, CD200R, Dok2, Elevated, In, In IFN-γ, Interaction, M2, NK, RasGAP, T-cell, Th2, TNF-α
related to Pathogens modulate CD200-CD200R axis · 12
CD200 → CD170a-dependent, CD200-encoding, CD200R, Due, IFN-γ, Kaposi, KSHV, NK, OX2, Particularly, This, TNF-α
related to Mechanism of action · 9
CD200 → CD200R, DOK-1, DOK-2, MAPK/ERK, PTB, RasGAP, SHIP, The, This
related to In cancer · 8
CD200 → B-cell, CD200R, In, It, MDSC, MDSCs, The, These
related to In transplantation · 5
CD200 → IL-10, In, It, TGF-β, This
related to Expression · 4
CD200 → In, Moreover, NLR, TLR

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

gene cells cd200r human macrophages chromosome expressed expression tumor protein bp also chr band lymphocytes membrane activation response function leads

CD200 relationships Subject–Predicate–Object triples

TTTA extracted 178 structured relationships around CD200. Examples in this analysis include CD200 → Aliases → CD200, CD200 molecule, MOX1, MOX2, MRC, OX-2, CD-200 and CD200 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4BFI. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
CD200AliasesCD200, CD200 molecule, MOX1, MOX2, MRC, OX-2, CD-2001.00infobox
CD200Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4BFI1.00infobox
CD200Band3q13.21.00infobox
CD200Band16 B5|16 29.53 cM1.00infobox
CD200Bgeefrontal pole1.00infobox
CD200Bgeeganglionic eminence1.00infobox
CD200BgeeBrodmann area 101.00infobox
CD200Bgeemiddle frontal gyrus1.00infobox
CD200Bgeehypothalamus1.00infobox
CD200Bgeeorbitofrontal cortex1.00infobox
CD200BgeeBrodmann area 91.00infobox
CD200Bgeeparietal pleura1.00infobox
CD200BgeeBrodmann area 461.00infobox
CD200BgeeBrodmann area 231.00infobox
CD200Bgeeascending aorta1.00infobox
CD200Bgeetunica media of zone of aorta1.00infobox
CD200Bgeeventral tegmental area1.00infobox
CD200Bgeedorsomedial hypothalamic nucleus1.00infobox
CD200Bgeeventromedial nucleus1.00infobox
CD200Bgeeparaventricular nucleus of hypothalamus1.00infobox
CD200Bgeesuprachiasmatic nucleus1.00infobox
CD200Bgeebody of femur1.00infobox
CD200Bgeearcuate nucleus1.00infobox
CD200Bgeeaortic valve1.00infobox
CD200BioGPSMore reference expression data1.00infobox
CD200Chr.Chromosome 3 (human)1.00infobox
CD200Chr.Chromosome 16 (mouse)1.00infobox
CD200DatabasesNCBI: entry; OMA: entry1.00infobox
CD200End112,362,812 bp1.00infobox
CD200End45,229,416 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around CD200 bring nearby vocabulary together. In this analysis, examples include Cells, Expression and Gene. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • CD200
    • Cells
    • Expression
    • Gene
    • Human
    • Expressed
    • Cd200r
    • Cancer
    • Function
    • Protein
    • Shown
    • Chromosome
    • Tumor
  • cd200
    • Cells
    • Expression
    • Gene
    • Human
    • Expressed
    • Cd200r
    • Cancer
    • Function
    • Protein
    • Shown
    • Chromosome
    • Tumor
  • gene
    • Human
    • Chromosome
    • Location
    • Membrane
    • Bp
    • Chr
    • Protein
    • Glycoprotein
    • Mouse
    • Ox-2
    • Band
    • Function
  • chromosome
    • Bp
    • Chr
    • Gene
    • Band
    • Location
    • Human
    • Mouse
    • Function
    • Expression
    • Ox-2
    • Receptor
    • Cancer
  • endothelial cells
    • Expressed
    • Lymphocytes
    • Cd200r
    • Dendritic
    • Myeloid
    • Macrophages
    • Tumor
    • Human
    • Function
    • Immune
    • Response
    • Associated
  • hairy cell leukemia
    • Immune
    • Signaling
    • Production
    • Human
    • Activation
    • Response
    • Expressed
    • Cells
    • Mouse
    • Receptor
    • Dendritic
    • Inhibits
  • mast cells
    • Expressed
    • Lymphocytes
    • Cd200r
    • Dendritic
    • Myeloid
    • Macrophages
    • Tumor
    • Human
    • Function
    • Immune
    • Response
    • Associated
  • myeloid cells
    • Expressed
    • Lymphocytes
    • Tumor
    • Cd200r
    • Dendritic
    • Myeloid
    • Macrophages
    • Human
    • Function
    • Immune
    • Response
    • Associated

Connections between topic areas Semantic bridges

For CD200, one of the stronger structural bridges in this analysis connects CD200 with Expression. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
CD200Expression · splits 51 ⟂ 30
CD200Function · splits 64 ⟂ 17
CD200Clinical significance · splits 68 ⟂ 13
CD200Mechanism of action · splits 70 ⟂ 11
CD200Overview · splits 72 ⟂ 9

Map overview Semantic statistics

CD200

Nodes81
Edges80
Triples178
Avg. degree1.98
Density0.024691
Components1

Source & methodology

TTTA analyzes the structure around CD200 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Expression, Function & Clinical significance, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — CD200 · EN edition · Analysis: TopicsToTalkAbout

For writers, content strategists, SEOs, marketers and creators — from quick topic research to advanced semantic analysis.