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CD200

OX-2 membrane glycoprotein, also named CD200 (Cluster of Differentiation 200) is a human protein encoded by the CD200 gene. In humans, the CD200 gene is located on chromosome 3 in proximity to genes encoding the other B7 proteins CD80/CD86. In mice, the CD200 gene is located on chromosome 16.

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Aliases
CD200, CD200 molecule, MOX1, MOX2, MRC, OX-2, CD-200
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4BFI
Band
3q13.2 · 16 B5|16 29.53 cM
Bgee
frontal pole · ganglionic eminence · Brodmann area 10 · middle frontal gyrus · hypothalamus
BioGPS
More reference expression data
Chr.
Chromosome 3 (human) · Chromosome 16 (mouse)

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Overview

Expression

Function

Mechanism of action

Clinical significance

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Map overview Semantic statistics

CD200

Nodes81
Edges80
Triples178
Avg. degree1.98
Density0.024691
Components1

How this topic connects Entity context

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CD200

Top relations

Gene ontology · 35
CD200 → axon, cell adhesion molecule binding, cell body, cell recognition, cell surface, cell-cell adhesion, glycosylated region protein binding, heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules, heterotypic cell-cell adhesion, homophilic cell adhesion via plasma membrane adhesion molecules, integral component of membrane, integral component of plasma membrane, membrane, negative regulation of cell population proliferation, negative regulation of leukocyte activation, negative regulation of macrophage activation, negative regulation of macrophage migration, negative regulation of matrix metallopeptidase secretion, negative regulation of neuroinflammatory response, negative regulation of neuron death
Bgee · 20
CD200 → aortic valve, arcuate nucleus, ascending aorta, body of femur, Brodmann area 10, Brodmann area 23, Brodmann area 46, Brodmann area 9, dorsomedial hypothalamic nucleus, frontal pole, ganglionic eminence, hypothalamus, middle frontal gyrus, orbitofrontal cortex, paraventricular nucleus of hypothalamus, parietal pleura, suprachiasmatic nucleus, tunica media of zone of aorta, ventral tegmental area, ventromedial nucleus
RNA expression pattern · 20
CD200 → aortic valve, arcuate nucleus, ascending aorta, body of femur, Brodmann area 10, Brodmann area 23, Brodmann area 46, Brodmann area 9, dorsomedial hypothalamic nucleus, frontal pole, ganglionic eminence, hypothalamus, middle frontal gyrus, orbitofrontal cortex, paraventricular nucleus of hypothalamus, parietal pleura, suprachiasmatic nucleus, tunica media of zone of aorta, ventral tegmental area, ventromedial nucleus
related to External links · 15
CD200 → Antigen, Human CD200, Medicine, Medicine Medical Subject Headings, MeSH, Mouse OX-2, National Library, O54901, Overview, PDB, PDBe-KB, This, UCSC Genome Browser, UniProt, United States National Library
related to Function · 13
CD200 → CD200-CD200R, CD200R, Dok2, Elevated, In, In IFN-γ, Interaction, M2, NK, RasGAP, T-cell, Th2, TNF-α
related to Pathogens modulate CD200-CD200R axis · 12
CD200 → CD170a-dependent, CD200-encoding, CD200R, Due, IFN-γ, Kaposi, KSHV, NK, OX2, Particularly, This, TNF-α
related to Mechanism of action · 9
CD200 → CD200R, DOK-1, DOK-2, MAPK/ERK, PTB, RasGAP, SHIP, The, This
related to In cancer · 8
CD200 → B-cell, CD200R, In, It, MDSC, MDSCs, The, These
related to In transplantation · 5
CD200 → IL-10, In, It, TGF-β, This
related to Expression · 4
CD200 → In, Moreover, NLR, TLR

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Important terminology

gene cells cd200r human macrophages chromosome expressed expression tumor protein bp also chr band lymphocytes membrane activation response function leads

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
CD200AliasesCD200, CD200 molecule, MOX1, MOX2, MRC, OX-2, CD-2001.00infobox
CD200Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4BFI1.00infobox
CD200Band3q13.21.00infobox
CD200Band16 B5|16 29.53 cM1.00infobox
CD200Bgeefrontal pole1.00infobox
CD200Bgeeganglionic eminence1.00infobox
CD200BgeeBrodmann area 101.00infobox
CD200Bgeemiddle frontal gyrus1.00infobox
CD200Bgeehypothalamus1.00infobox
CD200Bgeeorbitofrontal cortex1.00infobox
CD200BgeeBrodmann area 91.00infobox
CD200Bgeeparietal pleura1.00infobox
CD200BgeeBrodmann area 461.00infobox
CD200BgeeBrodmann area 231.00infobox
CD200Bgeeascending aorta1.00infobox
CD200Bgeetunica media of zone of aorta1.00infobox
CD200Bgeeventral tegmental area1.00infobox
CD200Bgeedorsomedial hypothalamic nucleus1.00infobox
CD200Bgeeventromedial nucleus1.00infobox
CD200Bgeeparaventricular nucleus of hypothalamus1.00infobox
CD200Bgeesuprachiasmatic nucleus1.00infobox
CD200Bgeebody of femur1.00infobox
CD200Bgeearcuate nucleus1.00infobox
CD200Bgeeaortic valve1.00infobox
CD200BioGPSMore reference expression data1.00infobox
CD200Chr.Chromosome 3 (human)1.00infobox
CD200Chr.Chromosome 16 (mouse)1.00infobox
CD200DatabasesNCBI: entry; OMA: entry1.00infobox
CD200End112,362,812 bp1.00infobox
CD200End45,229,416 bp1.00infobox

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