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CD16: Art, As a drug target & Clinical significance

CD16, also known as FcγRIII, is a cluster of differentiation molecule found on the surface of natural killer cells, neutrophils, monocytes, macrophages, and certain T cells. CD16 has been identified as Fc receptors FcγRIIIa (CD16a) and FcγRIIIb (CD16b), which participate in signal transduction. The most well-researched membrane receptor implicated in…

Language: English [EN]

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CD16 topic overview

The analysis highlights Art, As a drug target and Clinical significance as prominent areas in the source structure around CD16.

Related topics: 46
Source areas: 5
Connected nodes: 51
Extracted relationships: 82
Concept neighborhoods: 20
Bridge connections: 51

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 15 topics

As a drug target · 11 topics

Clinical significance · 10 topics

Function · 7 topics

Mechanism and regulation · 3 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Alt. symbols: FCGR3, FCG3
Domains: InterPro
HGNC: 3619
Locus: Chr. 1 q23
NCBI gene: 2214
OMIM: 146740

Suggested research paths

A focused starting point derived from the topic graph, ranked independently of the source article order.

Start with these areas

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Cluster of differentiation
Natural killer cells Natural killer cell
Neutrophils Neutrophil
Monocytes
Macrophages
T cells
Fc receptors Fc receptor
FcγRIIIa
FcγRIIIb
Signal transduction
Membrane receptor
Immunoglobulin superfamily
Antibody-dependent cellular cytotoxicity Antibody-dependent cell-mediated cytotoxicity
Fluorescent-activated cell sorting
Magnetic-activated cell sorting

Function

Mechanism and regulation

IgG Immunoglobulin G
Hepatitis B virus
Cyclosporin A Ciclosporin

Clinical significance

CD38
Leukocytes Leukocyte
Passage of leukocytes through blood vessel walls Leukocyte extravasation
CD11b
CD33
Myeloid-derived suppressor cells Myeloid-derived suppressor cell
CD14
CD15
Organ transplantation
COVID-19

As a drug target

Margetuximab
Human epidermal growth factor receptor 2 (HER2) HER2/neu
CD19
Diabodies Single-chain variable fragment
Lymphomas Lymphoma
FasL Fas ligand
TRAIL
Death receptors Death receptor
Apoptosis
Autocrine
Paracrine

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How CD16 connects Entity context

The extracted context around CD16 shows recurring relationship patterns in the source. For example, CD16 → ADCC, After, CD25, CsA, CsA-sensitive, Fc, IFN-gamma, IgG, IL-2-R, In, NFATp, NK, The, These, This CD16-induced, TNF Another extracted example is CD16 → Anti-CD19/CD16, B-cell, Bispecific, CD16A, CD16B, CD19/CD16, FasL, Fc-optimized, FcγRIV, Furthermore, HER2, In, Margetuximab, TRAIL, With. Use these groups to spot repeated connection types before inspecting the individual relationships.

CD16

Top relations

related to Mechanism and regulation · 16

CD16 → ADCC, After, CD25, CsA, CsA-sensitive, Fc, IFN-gamma, IgG, IL-2-R, In, NFATp, NK, The, These, This CD16-induced, TNF

related to As a drug target · 15

CD16 → Anti-CD19/CD16, B-cell, Bispecific, CD16A, CD16B, CD19/CD16, FasL, Fc-optimized, FcγRIV, Furthermore, HER2, In, Margetuximab, TRAIL, With

related to Structure · 13

CD16 → C-terminal Ig, Fc, FcγRIIa, FcγRIIb, FcγRIII, FcγRIIIb, FcεRIα, Ig, Ig-like, In, Specifically, The, These

related to Function · 9

CD16 → CD16a, CD16b, Fc, FcγRIIIa, FcγRIIIb, GPI, III Fcγ, In, While FcγRIIIa

related to Clinical significance · 7

CD16 → ADCC, After, CD38, FcγRIII, However, In, NK

related to External links · 4

CD16 → Antigens, Medicine Medical Subject Headings, MeSH, National Library

is a · 2

CD16 → molecule of the immunoglobulin superfamily, type III Fcγ receptor

Alt. symbols · 1

CD16 → FCGR3, FCG3

Domains · 1

CD16 → InterPro

HGNC · 1

CD16 → 3619

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

cells nk cell neutrophils monocytes fcγriiib receptor antibodies human expression also fc cytotoxicity adcc fcγriiia degranulation addition cancer natural killer

CD16 relationships Subject–Predicate–Object triples

TTTA extracted 82 structured relationships around CD16. Examples in this analysis include CD16 → Alt. symbols → FCGR3, FCG3 and CD16 → Domains → InterPro. The table shows each extracted connection, where it came from and its confidence.

Subject	Predicate	Object	Confidence	Src
CD16	Alt. symbols	FCGR3, FCG3	1.00	infobox
CD16	Domains	InterPro	1.00	infobox
CD16	HGNC	3619	1.00	infobox
CD16	Locus	Chr. 1 q23	1.00	infobox
CD16	NCBI gene	2214	1.00	infobox
CD16	OMIM	146740	1.00	infobox
CD16	RefSeq	NM_000569	1.00	infobox
CD16	Search for	Search forStructuresSwiss-modelDomainsInterPro	1.00	infobox
CD16	Structures	Swiss-model	1.00	infobox
CD16	Symbol	FCGR3A	1.00	infobox
CD16	UniProt	P08637	1.00	infobox
CD16	is a	molecule of the immunoglobulin superfamily	0.90	text
CD16	is a	type III Fcγ receptor	0.90	text

Related concept clusters Concept neighborhoods

The concept neighborhoods around CD16 bring nearby vocabulary together. In this analysis, examples include Cells, Cell and Nk. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

CD16
- Cells
- Cell
- Nk
- Cancer
- Antibodies
- Immune
- Adcc
- Monocytes
- Neutrophils
- Allows
- Antibody-dependent
- Killer
cd16
- Cells
- Cell
- Nk
- Cancer
- Antibodies
- Immune
- Adcc
- Monocytes
- Neutrophils
- Allows
- Antibody-dependent
- Killer
natural killer cells
- Natural
- Macrophages
- Nk
- Antibodies
- Human
- Molecule
- Neutrophils
- Adcc
- Cytotoxicity
- Surface
- Fcγriiia
- Antibody-dependent
t cells
- Nk
- Antibodies
- Human
- Adcc
- Cytotoxicity
- Antibody-dependent
- Immune
- Killer
- Natural
- Used
- Receptor
- Cell
mast cells
- Nk
- Antibodies
- Human
- Adcc
- Cytotoxicity
- Antibody-dependent
- Immune
- Killer
- Natural
- Used
- Receptor
- Cell
myeloid-derived suppressor cells
- Nk
- Antibodies
- Human
- Adcc
- Cytotoxicity
- Antibody-dependent
- Immune
- Killer
- Natural
- Used
- Receptor
- Cell
fluorescent-activated cell sorting
- Specific
- Degranulation
- Immune
- Addition
- Cancer
- Cytotoxicity
- Antibodies
- Cells
- Surface
- Allows
- Killer
- Natural
magnetic-activated cell sorting
- Specific
- Degranulation
- Immune
- Addition
- Cancer
- Cytotoxicity
- Antibodies
- Cells
- Surface
- Allows
- Killer
- Natural

Connections between topic areas Semantic bridges

For CD16, one of the stronger structural bridges in this analysis connects CD16 with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

CD16 — Overview · splits 36 ⟂ 16

CD16 — As a drug target · splits 40 ⟂ 12

CD16 — Clinical significance · splits 41 ⟂ 11

CD16 — Function · splits 44 ⟂ 8

CD16 — Mechanism and regulation · splits 48 ⟂ 4

Map overview Semantic statistics

CD16

Nodes52

Edges51

Triples82

Avg. degree1.96

Density0.038462

Components1

Source & methodology

TTTA analyzes the structure around CD16 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Art, As a drug target & Clinical significance, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — CD16 · EN edition · Analysis: TopicsToTalkAbout

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