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RNF43: Function & Overview

Ring finger protein 43 is a protein that in humans is encoded by the RNF43 gene.

Language: English [EN]
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RNF43 topic overview

The analysis highlights Function and Overview as prominent areas in the source structure around RNF43.

Related topics
3
Source areas
2
Connected nodes
5
Extracted relationships
96
Concept neighborhoods
5
Bridge connections
5

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 2 topics
Function · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

2.3.2.27
Aliases
RNF43, RNF124, URCC, ring finger protein 43, SSPCS
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4KNG
Band
17q22 · 11|11 C
Bgee
rectum · gingival epithelium · mucosa of sigmoid colon · mucosa of transverse colon · duodenum
BioGPS
n/a

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How RNF43 connects Entity context

The extracted context around RNF43 shows recurring relationship patterns in the source. For example, RNF43 → endoplasmic reticulum, endoplasmic reticulum membrane, frizzled binding, integral component of membrane, integral component of plasma membrane, membrane, metal ion binding, multicellular organism development, negative regulation of Wnt signaling pathway, nuclear envelope, nucleus, plasma membrane, protein binding, protein ubiquitination, stem cell proliferation, transferase activity, ubiquitin protein ligase activity, ubiquitin-dependent protein catabolic process, ubiquitin-protein transferase activity, Wnt receptor catabolic process Another extracted example is RNF43 → crypt of lieberkuhn of small intestine, duodenum, ectoderm, epithelium of colon, female urethra, genital tubercle, gingival epithelium, gonad, jejunal mucosa, mucosa of sigmoid colon, mucosa of transverse colon, otic placode, otic vesicle, parotid gland, rectum, right adrenal cortex, saccule, thin ascending limb of loop of Henle, zygote. Use these groups to spot repeated connection types before inspecting the individual relationships.

RNF43

Top relations

Gene ontology · 21
RNF43 → endoplasmic reticulum, endoplasmic reticulum membrane, frizzled binding, integral component of membrane, integral component of plasma membrane, membrane, metal ion binding, multicellular organism development, negative regulation of Wnt signaling pathway, nuclear envelope, nucleus, plasma membrane, protein binding, protein ubiquitination, stem cell proliferation, transferase activity, ubiquitin protein ligase activity, ubiquitin-dependent protein catabolic process, ubiquitin-protein transferase activity, Wnt receptor catabolic process
Bgee · 19
RNF43 → crypt of lieberkuhn of small intestine, duodenum, ectoderm, epithelium of colon, female urethra, genital tubercle, gingival epithelium, gonad, jejunal mucosa, mucosa of sigmoid colon, mucosa of transverse colon, otic placode, otic vesicle, parotid gland, rectum, right adrenal cortex, saccule, thin ascending limb of loop of Henle, zygote
RNA expression pattern · 19
RNF43 → crypt of lieberkuhn of small intestine, duodenum, ectoderm, epithelium of colon, female urethra, genital tubercle, gingival epithelium, gonad, jejunal mucosa, mucosa of sigmoid colon, mucosa of transverse colon, otic placode, otic vesicle, parotid gland, rectum, right adrenal cortex, saccule, thin ascending limb of loop of Henle, zygote
related to Function · 12
RNF43 → Alternative, Cancer-associated RNF43, Importantly, Mar, N-terminal RNF43, RefSeq, RING, RING-type E3, The, This, Wnt, Wnt-receptor
Band · 2
RNF43 → 11|11 C, 17q22
Chr. · 2
RNF43 → Chromosome 11 (mouse), Chromosome 17 (human)
End · 2
RNF43 → 58,417,595 bp, 87,626,365 bp
2.3.2.27 · 1
RNF43 → ↗
Aliases · 1
RNF43 → RNF43, RNF124, URCC, ring finger protein 43, SSPCS
Available structures · 1
RNF43 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4KNG

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

bp gene protein chr human band chromosome 17 ring location function mouse wnt signaling finger 43 encoded search activity 417

RNF43 relationships Subject–Predicate–Object triples

TTTA extracted 96 structured relationships around RNF43. Examples in this analysis include RNF43 → 2.3.2.27 → ↗ and RNF43 → Aliases → RNF43, RNF124, URCC, ring finger protein 43, SSPCS. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
RNF432.3.2.271.00infobox
RNF43AliasesRNF43, RNF124, URCC, ring finger protein 43, SSPCS1.00infobox
RNF43Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4KNG1.00infobox
RNF43Band17q221.00infobox
RNF43Band11|11 C1.00infobox
RNF43Bgeerectum1.00infobox
RNF43Bgeegingival epithelium1.00infobox
RNF43Bgeemucosa of sigmoid colon1.00infobox
RNF43Bgeemucosa of transverse colon1.00infobox
RNF43Bgeeduodenum1.00infobox
RNF43Bgeeparotid gland1.00infobox
RNF43Bgeejejunal mucosa1.00infobox
RNF43Bgeeepithelium of colon1.00infobox
RNF43Bgeeright adrenal cortex1.00infobox
RNF43Bgeegonad1.00infobox
RNF43Bgeesaccule1.00infobox
RNF43Bgeethin ascending limb of loop of Henle1.00infobox
RNF43Bgeeectoderm1.00infobox
RNF43Bgeeotic vesicle1.00infobox
RNF43Bgeeotic placode1.00infobox
RNF43Bgeegenital tubercle1.00infobox
RNF43Bgeefemale urethra1.00infobox
RNF43Bgeecrypt of lieberkuhn of small intestine1.00infobox
RNF43Bgeezygote1.00infobox
RNF43BioGPSn/a1.00infobox
RNF43Chr.Chromosome 17 (human)1.00infobox
RNF43Chr.Chromosome 11 (mouse)1.00infobox
RNF43DatabasesNCBI: entry; OMA: entry1.00infobox
RNF43End58,417,595 bp1.00infobox
RNF43End87,626,365 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around RNF43 bring nearby vocabulary together. In this analysis, examples include Membrane, Mutations and Search. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • protein
    • Gene
    • Function
    • Ring
    • Rnf43
    • Activity
    • Encoded
    • Expression
    • Frizzled
    • Nuclear
    • Search
    • Ubiquitination
    • Location
  • gene
    • Protein
    • Location
    • Ring
    • Chromosome
    • Human
    • Bp
    • Chr
    • Rnf43
    • Activity
    • End
    • Expression
    • Frizzled
  • function
    • Activity
    • Nuclear
    • Search
    • Protein
    • Location
    • Ring
    • Chromosome
    • Human
    • Bp
    • Chr
    • Gene
    • Ligase
  • RNF43
    • Membrane
    • Mutations
    • Search
    • Location
    • Signaling
    • Wnt
    • Human
    • Ligase
    • Ubiquitin
    • Domain
    • End
    • Expression
  • rnf43
    • Membrane
    • Mutations
    • Search
    • Location
    • Signaling
    • Wnt
    • Human
    • Ligase
    • Ubiquitin
    • Domain
    • End
    • Expression

Connections between topic areas Semantic bridges

For RNF43, one of the stronger structural bridges in this analysis connects RNF43 with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
RNF43Overview · splits 3 ⟂ 3

Map overview Semantic statistics

RNF43

Nodes6
Edges5
Triples96
Avg. degree1.67
Density0.333333
Components1

Source & methodology

TTTA analyzes the structure around RNF43 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — RNF43 · EN edition · Analysis: TopicsToTalkAbout

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