AXIN1

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Explore the main themes, entities and connections around AXIN1. Start with the topic map, then use the sections below for research and deeper semantic analysis.

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Function

Regulator of G-protein signaling (RGS) domain Dishevelled Catenin WNT Apoptosis

14 related topics

Interactions

Interact APC CTNNB1 CSNK1E CSNK1A1

12 related topics

Structure

N-terminal C-terminal BRCA1 Adenomatous polyposis coli CREB-binding protein

5 related topics

Overview

Protein Gene

2 related topics

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases: AXIN1, AXIN, PPP1R49, axin 1
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1DK8, 1EMU, 1O9U, 3ZDI, 4B7T, 4NM0, 4NM3, 4NM5, 4NM7, 4NU1
Band: 16p13.3 · 17 A3.3|17 13.07 cM
Bgee: granulocyte · mucosa of transverse colon · right hemisphere of cerebellum · gastrocnemius muscle · skin of leg
BioGPS: More reference expression data
Chr.: Chromosome 16 (human) · Chromosome 17 (mouse)

Topics to explore

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Overview

Function

Regulator of G-protein signaling (RGS) domain Regulator of G protein signaling
Dishevelled
Catenin
WNT Wnt signaling pathway
Apoptosis
Hepatocellular carcinoma
Hepatoblastomas Hepatoblastoma
Medulloblastomas Medulloblastoma
Β-catenin
Tankyrase
Truncating mutations Truncating mutation
Colorectal Colorectal cancer
Liver cancers Liver cancer
Oncogene

Structure

Interactions

Interact Protein-protein interaction
APC APC (gene)
CTNNB1 Beta-catenin
CSNK1E
CSNK1A1 Casein kinase 1, alpha 1
DVL1
GSK3B
LRP5
MAP3K1
PPP2R5A
RNF43
TSC2

Advanced semantic analysis

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Map overview Semantic statistics

Nodes38

Edges37

Triples174

Avg. degree1.95

Density0.052632

Components1

How this topic connects Entity context

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AXIN1

Top relations

Gene ontology · 60

AXIN1 → activation of protein kinase activity, apoptotic process, armadillo repeat domain binding, axial mesoderm formation, beta-catenin binding, beta-catenin destruction complex, beta-catenin destruction complex assembly, beta-catenin destruction complex disassembly, canonical Wnt signaling pathway, canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation, cell periphery, cytoplasm, cytoplasmic microtubule organization, cytoplasmic vesicle, cytosol, determination of left/right symmetry, embryonic eye morphogenesis, embryonic skeletal joint morphogenesis, enzyme binding, forebrain anterior/posterior pattern specification

Bgee · 19

AXIN1 → blood, corneal stroma, epiblast, gastrocnemius muscle, genital tubercle, granulocyte, Ileal epithelium, monocyte, mononuclear cell, mucosa of transverse colon, Paneth cell, popliteal artery, right hemisphere of cerebellum, skin of abdomen, skin of leg, tail of embryo, thymus, ventricular zone, zygote

RNA expression pattern · 19

related to Function · 18

AXIN1 → APC, AXIN1-truncating, AXIN2, Consistently, CTNNB1, DIX, G-protein, Importantly, MMTV, Mutation, Mutations, RGS, The, The AXIN, This, Thus AXIN1, Two, WNT

related to Structure · 15

AXIN1 → Adenomatous, Biophysical, BRCA1, C-terminal DIX, CBP, CREB-binding, GSK3, IDPs, Intrinsically Disordered Proteins, Large WNT-downregulating, Many, RGS, The, The N-terminal RGS, Wnt

related to Interactions · 10

AXIN1 → APC, CSNK1A1, CSNK1E, CTNNB1, DVL1, GSK3B, LRP5, MAP3K1, PPP2R5A, RNF43

related to External links · 8

AXIN1 → Axin-1, Human AXIN1, O15169, Overview, PDB, PDBe-KB, UCSC Genome Browser, UniProt

Band · 2

AXIN1 → 16p13.3, 17 A3.3|17 13.07 cM

Chr. · 2

AXIN1 → Chromosome 16 (human), Chromosome 17 (mouse)

End · 2

AXIN1 → 26,414,785 bp, 352,723 bp

Important terminology Word statistics

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Important terminology

gene protein human bp chr band chromosome 16 location β-catenin signaling domain wnt mutations mouse axin complex kinase function external

Entity relationships Subject–Predicate–Object triples

Subject	Predicate	Object	Confidence	Src
AXIN1	Aliases	AXIN1, AXIN, PPP1R49, axin 1	1.00	infobox
AXIN1	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1DK8, 1EMU, 1O9U, 3ZDI, 4B7T, 4NM0, 4NM3, 4NM5, 4NM7, 4NU1	1.00	infobox
AXIN1	Band	16p13.3	1.00	infobox
AXIN1	Band	17 A3.3\|17 13.07 cM	1.00	infobox
AXIN1	Bgee	granulocyte	1.00	infobox
AXIN1	Bgee	mucosa of transverse colon	1.00	infobox
AXIN1	Bgee	right hemisphere of cerebellum	1.00	infobox
AXIN1	Bgee	gastrocnemius muscle	1.00	infobox
AXIN1	Bgee	skin of leg	1.00	infobox
AXIN1	Bgee	mononuclear cell	1.00	infobox
AXIN1	Bgee	monocyte	1.00	infobox
AXIN1	Bgee	skin of abdomen	1.00	infobox
AXIN1	Bgee	blood	1.00	infobox
AXIN1	Bgee	popliteal artery	1.00	infobox
AXIN1	Bgee	Ileal epithelium	1.00	infobox
AXIN1	Bgee	tail of embryo	1.00	infobox
AXIN1	Bgee	ventricular zone	1.00	infobox
AXIN1	Bgee	genital tubercle	1.00	infobox
AXIN1	Bgee	epiblast	1.00	infobox
AXIN1	Bgee	zygote	1.00	infobox
AXIN1	Bgee	Paneth cell	1.00	infobox
AXIN1	Bgee	corneal stroma	1.00	infobox
AXIN1	Bgee	thymus	1.00	infobox
AXIN1	BioGPS	More reference expression data	1.00	infobox
AXIN1	Chr.	Chromosome 16 (human)	1.00	infobox
AXIN1	Chr.	Chromosome 17 (mouse)	1.00	infobox
AXIN1	Databases	NCBI: entry; OMA: entry	1.00	infobox
AXIN1	End	352,723 bp	1.00	infobox
AXIN1	End	26,414,785 bp	1.00	infobox
AXIN1	Ensembl	ENSG00000103126	1.00	infobox

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