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Apolipoprotein L1

Apolipoprotein L1 is a protein that in humans is encoded by the APOL1 gene. Two transcript variants encoding two different isoforms have been found for this gene.

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Aliases
APOL1, APO-L, APOL, APOL-I, FSGS4, apolipoprotein L1
Available structures
Available structuresPDBHuman UniProt search: PDBe RCSB List of PDB id codes7L6K, 7LF7, 7LFA, 7LFB, 7LFD
Band
22q12.3
Bgee
gallbladder · right lobe of liver · smooth muscle tissue · appendix · pericardium
BioGPS
More reference expression data
Chr.
Chromosome 22 (human)

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Apolipoprotein L1

Nodes43
Edges42
Triples78
Avg. degree1.95
Density0.046512
Components1

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Apolipoprotein L1

Top relations

Gene ontology · 22
Apolipoprotein L1 → blood microparticle, chloride channel activity, chloride transmembrane transport, cholesterol metabolic process, cytolysis, endoplasmic reticulum lumen, extracellular region, extracellular space, high-density lipoprotein particle, innate immune response, intrinsic component of membrane, killing of cells of other organism, lipid binding, lipid metabolism, lipid transport, lipoprotein metabolic process, post-translational protein modification, protein binding, receptor-mediated endocytosis, steroid metabolic process
related to Function · 13
Apolipoprotein L1 → A1, APOA1, APOL1, HDL, HDL3, HPR, If, In, It, Once, The, The APOL1, TLF
Bgee · 10
Apolipoprotein L1 → apex of heart, appendix, decidua, gallbladder, nasal epithelium, pericardium, right lobe of liver, right lung, smooth muscle tissue, upper lobe of left lung
RNA expression pattern · 10
Apolipoprotein L1 → apex of heart, appendix, decidua, gallbladder, nasal epithelium, pericardium, right lobe of liver, right lung, smooth muscle tissue, upper lobe of left lung
Aliases · 1
Apolipoprotein L1 → APOL1, APO-L, APOL, APOL-I, FSGS4, apolipoprotein L1
Available structures · 1
Apolipoprotein L1 → Available structuresPDBHuman UniProt search: PDBe RCSB List of PDB id codes7L6K, 7LF7, 7LFA, 7LFB, 7LFD
Band · 1
Apolipoprotein L1 → 22q12.3
BioGPS · 1
Apolipoprotein L1 → More reference expression data
Chr. · 1
Apolipoprotein L1 → Chromosome 22 (human)
Databases · 1
Apolipoprotein L1 → NCBI: entry; OMA: entry

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Important terminology

apol1 risk variants african alleles two kidney fsgs protein gene human g1 disease also prevalence eskd allele found apolipoprotein g2

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Apolipoprotein L1AliasesAPOL1, APO-L, APOL, APOL-I, FSGS4, apolipoprotein L11.00infobox
Apolipoprotein L1Available structuresAvailable structuresPDBHuman UniProt search: PDBe RCSB List of PDB id codes7L6K, 7LF7, 7LFA, 7LFB, 7LFD1.00infobox
Apolipoprotein L1Band22q12.31.00infobox
Apolipoprotein L1Bgeegallbladder1.00infobox
Apolipoprotein L1Bgeeright lobe of liver1.00infobox
Apolipoprotein L1Bgeesmooth muscle tissue1.00infobox
Apolipoprotein L1Bgeeappendix1.00infobox
Apolipoprotein L1Bgeepericardium1.00infobox
Apolipoprotein L1Bgeeupper lobe of left lung1.00infobox
Apolipoprotein L1Bgeeapex of heart1.00infobox
Apolipoprotein L1Bgeedecidua1.00infobox
Apolipoprotein L1Bgeenasal epithelium1.00infobox
Apolipoprotein L1Bgeeright lung1.00infobox
Apolipoprotein L1BioGPSMore reference expression data1.00infobox
Apolipoprotein L1Chr.Chromosome 22 (human)1.00infobox
Apolipoprotein L1DatabasesNCBI: entry; OMA: entry1.00infobox
Apolipoprotein L1End36,267,530 bp1.00infobox
Apolipoprotein L1EnsemblENSG000001003421.00infobox
Apolipoprotein L1Entrez85421.00infobox
Apolipoprotein L1External IDsOMIM: 607254, 603743; GeneCards: APOL11.00infobox
Apolipoprotein L1Gene location (Human)Gene location (Human)Chr.Chromosome 22 (human)Band22q12.3Start36,253,071 bpEnd36,267,530 bp1.00infobox
Apolipoprotein L1Gene ontologyprotein binding1.00infobox
Apolipoprotein L1Gene ontologychloride channel activity1.00infobox
Apolipoprotein L1Gene ontologylipid binding1.00infobox
Apolipoprotein L1Gene ontologyextracellular region1.00infobox
Apolipoprotein L1Gene ontologyintrinsic component of membrane1.00infobox
Apolipoprotein L1Gene ontologyblood microparticle1.00infobox
Apolipoprotein L1Gene ontologyvery-low-density lipoprotein particle1.00infobox
Apolipoprotein L1Gene ontologyhigh-density lipoprotein particle1.00infobox
Apolipoprotein L1Gene ontologyextracellular space1.00infobox

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