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Emerin

Emerin is a protein that in humans is encoded by the EMD gene, also known as the STA gene. Emerin, together with LEMD3, is a LEM domain-containing integral protein of the inner nuclear membrane in vertebrates. Emerin is highly expressed in cardiac and skeletal muscle. In cardiac muscle, emerin localizes to adherens junctions within intercalated discs…

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Aliases
EMD, EDMD, LEMD5, STA, emerin
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1JEI, 2ODC, 2ODG
Band
Xq28 · X A7.3|X 37.92 cM
Bgee
left ovary · left uterine tube · popliteal artery · tibial arteries · right ovary
BioGPS
More reference expression data
Chr.
X chromosome (human) · X chromosome (mouse)

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Map overview Semantic statistics

Emerin

Nodes50
Edges49
Triples128
Avg. degree1.96
Density0.04
Components1

How this topic connects Entity context

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Emerin

Top relations

Gene ontology · 28
Emerin → actin binding, beta-tubulin binding, cadherin binding, cellular response to growth factor stimulus, cortical endoplasmic reticulum, cytoplasm, endoplasmic reticulum, integral component of membrane, membrane, microtubule, mitotic nuclear membrane disassembly, mitotic nuclear membrane reassembly, muscle contraction, muscle organ development, negative regulation of canonical Wnt signaling pathway, negative regulation of fibroblast proliferation, nuclear envelope, nuclear inner membrane, nuclear membrane, nuclear outer membrane
Bgee · 20
Emerin → anterior pituitary, aortic valve, ascending aorta, body of uterus, Descending thoracic aorta, gastric mucosa, genital tubercle, granulocyte, left ovary, left uterine tube, lip, medial ganglionic eminence, muscle of thigh, popliteal artery, right coronary artery, right ovary, tail of embryo, tibial arteries, ventricular zone, yolk sac
RNA expression pattern · 20
Emerin → anterior pituitary, aortic valve, ascending aorta, body of uterus, Descending thoracic aorta, gastric mucosa, genital tubercle, granulocyte, left ovary, left uterine tube, lip, medial ganglionic eminence, muscle of thigh, popliteal artery, right coronary artery, right ovary, tail of embryo, tibial arteries, ventricular zone, yolk sac
related to Clinical significance · 12
Emerin → Achilles, Approximately, Dreifuss, Emery, HIV-1, In, Moreover, Mutations, PR, Thus, X-linked, Xq28
related to Interactions · 11
Emerin → ACTA1, ACTG2, BANF1, BCLAF1, CTNNB1, GMCL1, LMNA, PSME1, SYNE1, SYNE2, TMEM43
related to Function · 8
Emerin → Dreifuss, EMD, Emery, In, It, STA, This, X-linked
related to Structure · 3
Emerin → In, MW, N-terminal
Band · 2
Emerin → X A7.3|X 37.92 cM, Xq28
Chr. · 2
Emerin → X chromosome (human), X chromosome (mouse)
End · 2
Emerin → 154,381,574 bp, 73,305,154 bp

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Important terminology

protein cardiac muscle gene bp human emery membrane emd chr band dreifuss muscular dystrophy chromosome nuclear skeletal function also inner

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
EmerinAliasesEMD, EDMD, LEMD5, STA, emerin1.00infobox
EmerinAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1JEI, 2ODC, 2ODG1.00infobox
EmerinBandXq281.00infobox
EmerinBandX A7.3|X 37.92 cM1.00infobox
EmerinBgeeleft ovary1.00infobox
EmerinBgeeleft uterine tube1.00infobox
EmerinBgeepopliteal artery1.00infobox
EmerinBgeetibial arteries1.00infobox
EmerinBgeeright ovary1.00infobox
EmerinBgeeanterior pituitary1.00infobox
EmerinBgeegastric mucosa1.00infobox
EmerinBgeebody of uterus1.00infobox
EmerinBgeeright coronary artery1.00infobox
EmerinBgeeDescending thoracic aorta1.00infobox
EmerinBgeegenital tubercle1.00infobox
EmerinBgeetail of embryo1.00infobox
EmerinBgeeventricular zone1.00infobox
EmerinBgeeyolk sac1.00infobox
EmerinBgeelip1.00infobox
EmerinBgeegranulocyte1.00infobox
EmerinBgeemedial ganglionic eminence1.00infobox
EmerinBgeemuscle of thigh1.00infobox
EmerinBgeeascending aorta1.00infobox
EmerinBgeeaortic valve1.00infobox
EmerinBioGPSMore reference expression data1.00infobox
EmerinChr.X chromosome (human)1.00infobox
EmerinChr.X chromosome (mouse)1.00infobox
EmerinDatabasesNCBI: entry; OMA: entry1.00infobox
EmerinEnd154,381,574 bp1.00infobox
EmerinEnd73,305,154 bp1.00infobox

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