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WNK1

WNK (lysine deficient protein kinase 1), also known as WNK1, is an enzyme that is encoded by the WNK1 gene. WNK1 is serine-threonine protein kinase and part of the "with no lysine/K" kinase WNK family. The predominant role of WNK1 is the regulation of cation-Cl− cotransporters (CCCs) such as the sodium chloride cotransporter (NCC), basolateral Na-K-Cl…

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2.7.11.1
Aliases
WNK1, HSAN2, HSN2, KDP, PPP1R167, PRKPSK, p65, WNK lysine deficient protein kinase 1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4PWN
Band
12p13.33 · 6|6 F1
Bgee
internal globus pallidus · inferior ganglion of vagus nerve · subthalamic nucleus · dorsal motor nucleus of vagus nerve · external globus pallidus
BioGPS
More reference expression data

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WNK1

Nodes67
Edges66
Triples215
Avg. degree1.97
Density0.029851
Components1

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WNK1

Top relations

Gene ontology · 51
WNK1 → activation of protein kinase activity, ATP binding, cellular response to calcium ion, cellular response to chemokine, chemokine (C-C motif) ligand 21 signaling pathway, chloride channel inhibitor activity, cytoplasm, cytosol, intracellular signal transduction, ion homeostasis, ion transport, kinase activity, lymphocyte migration into lymph node, magnesium ion binding, membrane, negative regulation of cell-cell adhesion mediated by integrin, negative regulation of GTPase activity, negative regulation of heterotypic cell-cell adhesion, negative regulation of kinase activity, negative regulation of leukocyte cell-cell adhesion
Bgee · 20
WNK1 → cardiac muscle tissue of left ventricle, ciliary body, dorsal motor nucleus of vagus nerve, endothelial cell of lymphatic vessel, external globus pallidus, gastrula, inferior ganglion of vagus nerve, inferior olivary nucleus, internal globus pallidus, myocardium of ventricle, optic nerve, pars compacta, pars reticulata, primary oocyte, right lung lobe, saccule, stroma of bone marrow, subthalamic nucleus, trabecular bone, vestibular membrane of cochlear duct
RNA expression pattern · 20
WNK1 → cardiac muscle tissue of left ventricle, ciliary body, dorsal motor nucleus of vagus nerve, endothelial cell of lymphatic vessel, external globus pallidus, gastrula, inferior ganglion of vagus nerve, inferior olivary nucleus, internal globus pallidus, myocardium of ventricle, optic nerve, pars compacta, pars reticulata, primary oocyte, right lung lobe, saccule, stroma of bone marrow, subthalamic nucleus, trabecular bone, vestibular membrane of cochlear duct
related to Regulation of WNK1 · 15
WNK1 → Cl, CUL3, Cullin3, DCT, E3, Furthermore, High, In, KLHL3, NCC, The, There, When, WNK1's, WNK4
related to Structure · 13
WNK1 → An, As, C-terminal, Further, HQ, In, MEKK, N-terminaldomain, Ser378, The, The WNK1, WNK, WNKs
related to Function · 11
WNK1 → CCC's N-terminaldomain, CCCs, Hence, OXSR1, Phosphorylation, SPAK, SPAK's, SPAK/OSR1, Sterile20, Studies, The WNK1
related to Cell volume regulation · 10
WNK1 → Another, Cl, In, KCC, Na, NKCC1/2, SPAK/OSR1, Studies, The, The NKCC1/2
related to Comparative genomics · 10
WNK1 → Arabidopsis, Chlamydomonas, Danio, Homologs, Taeniopygia, The, Vitis, WNK2, WNK3, WNK4
related to Potassium secretion · 10
WNK1 → ACH, Another, BKCa, CCD, CNT, ERK1, ERK2, ITSN1, Renal, ROMK1
related to WNK1 in the brain · 10
WNK1 → Cl, During, GABA, GABAA, In, KCC2, KCCs, NKCC1, SPAK/OSR1, Thus

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Important terminology

kinase protein cl ions activity cell bp gene ion domain blood pressure chr nkcc1 human band function sodium potassium within

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
WNK12.7.11.11.00infobox
WNK1AliasesWNK1, HSAN2, HSN2, KDP, PPP1R167, PRKPSK, p65, WNK lysine deficient protein kinase 11.00infobox
WNK1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4PWN1.00infobox
WNK1Band12p13.331.00infobox
WNK1Band6|6 F11.00infobox
WNK1Bgeeinternal globus pallidus1.00infobox
WNK1Bgeeinferior ganglion of vagus nerve1.00infobox
WNK1Bgeesubthalamic nucleus1.00infobox
WNK1Bgeedorsal motor nucleus of vagus nerve1.00infobox
WNK1Bgeeexternal globus pallidus1.00infobox
WNK1Bgeeoptic nerve1.00infobox
WNK1Bgeepars reticulata1.00infobox
WNK1Bgeetrabecular bone1.00infobox
WNK1Bgeepars compacta1.00infobox
WNK1Bgeeinferior olivary nucleus1.00infobox
WNK1Bgeeendothelial cell of lymphatic vessel1.00infobox
WNK1Bgeestroma of bone marrow1.00infobox
WNK1Bgeegastrula1.00infobox
WNK1Bgeeright lung lobe1.00infobox
WNK1Bgeevestibular membrane of cochlear duct1.00infobox
WNK1Bgeesaccule1.00infobox
WNK1Bgeeprimary oocyte1.00infobox
WNK1Bgeemyocardium of ventricle1.00infobox
WNK1Bgeeciliary body1.00infobox
WNK1Bgeecardiac muscle tissue of left ventricle1.00infobox
WNK1BioGPSMore reference expression data1.00infobox
WNK1Chr.Chromosome 12 (human)1.00infobox
WNK1Chr.Chromosome 6 (mouse)1.00infobox
WNK1DatabasesNCBI: entry; OMA: entry1.00infobox
WNK1End911,452 bp1.00infobox

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