WNK1

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WNK1 topic overview

The analysis highlights Art, Function and Structure as prominent areas in the source structure around WNK1.

Related topics: 61
Source areas: 5
Connected nodes: 66
Extracted relationships: 215
Concept neighborhoods: 24
Bridge connections: 66

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 27 topics

Clinical significance · 9 topics

Comparative genomics · 9 topics

Structure · 9 topics

Overview · 7 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

2.7.11.1: ↗
Aliases: WNK1, HSAN2, HSN2, KDP, PPP1R167, PRKPSK, p65, WNK lysine deficient protein kinase 1
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4PWN
Band: 12p13.33 · 6|6 F1
Bgee: internal globus pallidus · inferior ganglion of vagus nerve · subthalamic nucleus · dorsal motor nucleus of vagus nerve · external globus pallidus
BioGPS: More reference expression data

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Gene
Serine-threonine protein kinase
NCC Sodium chloride cotransporter
NKCC1
Blood pressure
Ions Ion
Cell Cell (biology)

Structure

Protein
N-terminal N-terminus
Domain Protein domain
C-terminal C-terminus
Kinase
MEKK protein kinase MAP kinase kinase kinase
Glycine loop Glycine loop?action=edit&redlink=1
Autophosphorylate Autophosphorylation
C-terminal domain

Function

Cytoplasmic
Serine-threonine kinase
Distal Anatomical terms of location
Nephron
Serine-threonine kinases Serine/threonine-specific protein kinase
OXSR1
Distal convoluted tubule
Sodium re absorption Sodium reabsorption
Intron
Expression Gene expression
Hypertension
SGK1
Epithelial sodium channel
Potassium channels Potassium channel
Cortical collecting duct Collecting duct system
Connecting tubule
ROMK1 ROMK
Arge conductance calcium-activated potassium channel BK channel
Clathrin-dependent endocytosis Receptor-mediated endocytosis
Intersectin Intersectin 1
Clathrin coated pits Clathrin-coated pit
Endocytosis
Hypotonic Tonicity
GABA Gamma-Aminobutyric acid
GABAA receptor
Hyperpolarization Hyperpolarization (biology)
Excitatory neurotransmitter Neurotransmitter

Clinical significance

Mutations Mutation
Pseudohypoaldosteronism
Congenital sensory neuropathy
HSAN Hereditary sensory and autonomic neuropathy
Perception
Pain
Touch
Heat
Sensory nerves Sensory nerve

Comparative genomics

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How WNK1 connects Entity context

The extracted context around WNK1 shows recurring relationship patterns in the source. For example, WNK1 → activation of protein kinase activity, ATP binding, cellular response to calcium ion, cellular response to chemokine, chemokine (C-C motif) ligand 21 signaling pathway, chloride channel inhibitor activity, cytoplasm, cytosol, intracellular signal transduction, ion homeostasis, ion transport, kinase activity, lymphocyte migration into lymph node, magnesium ion binding, membrane, negative regulation of cell-cell adhesion mediated by integrin, negative regulation of GTPase activity, negative regulation of heterotypic cell-cell adhesion, negative regulation of kinase activity, negative regulation of leukocyte cell-cell adhesion Another extracted example is WNK1 → cardiac muscle tissue of left ventricle, ciliary body, dorsal motor nucleus of vagus nerve, endothelial cell of lymphatic vessel, external globus pallidus, gastrula, inferior ganglion of vagus nerve, inferior olivary nucleus, internal globus pallidus, myocardium of ventricle, optic nerve, pars compacta, pars reticulata, primary oocyte, right lung lobe, saccule, stroma of bone marrow, subthalamic nucleus, trabecular bone, vestibular membrane of cochlear duct. Use these groups to spot repeated connection types before inspecting the individual relationships.

Top relations

Gene ontology · 51

WNK1 → activation of protein kinase activity, ATP binding, cellular response to calcium ion, cellular response to chemokine, chemokine (C-C motif) ligand 21 signaling pathway, chloride channel inhibitor activity, cytoplasm, cytosol, intracellular signal transduction, ion homeostasis, ion transport, kinase activity, lymphocyte migration into lymph node, magnesium ion binding, membrane, negative regulation of cell-cell adhesion mediated by integrin, negative regulation of GTPase activity, negative regulation of heterotypic cell-cell adhesion, negative regulation of kinase activity, negative regulation of leukocyte cell-cell adhesion

Bgee · 20

WNK1 → cardiac muscle tissue of left ventricle, ciliary body, dorsal motor nucleus of vagus nerve, endothelial cell of lymphatic vessel, external globus pallidus, gastrula, inferior ganglion of vagus nerve, inferior olivary nucleus, internal globus pallidus, myocardium of ventricle, optic nerve, pars compacta, pars reticulata, primary oocyte, right lung lobe, saccule, stroma of bone marrow, subthalamic nucleus, trabecular bone, vestibular membrane of cochlear duct

RNA expression pattern · 20

related to Regulation of WNK1 · 15

WNK1 → Cl, CUL3, Cullin3, DCT, E3, Furthermore, High, In, KLHL3, NCC, The, There, When, WNK1's, WNK4

related to Structure · 13

WNK1 → An, As, C-terminal, Further, HQ, In, MEKK, N-terminaldomain, Ser378, The, The WNK1, WNK, WNKs

related to Function · 11

WNK1 → CCC's N-terminaldomain, CCCs, Hence, OXSR1, Phosphorylation, SPAK, SPAK's, SPAK/OSR1, Sterile20, Studies, The WNK1

related to Cell volume regulation · 10

WNK1 → Another, Cl, In, KCC, Na, NKCC1/2, SPAK/OSR1, Studies, The, The NKCC1/2

related to Comparative genomics · 10

WNK1 → Arabidopsis, Chlamydomonas, Danio, Homologs, Taeniopygia, The, Vitis, WNK2, WNK3, WNK4

related to Potassium secretion · 10

WNK1 → ACH, Another, BKCa, CCD, CNT, ERK1, ERK2, ITSN1, Renal, ROMK1

related to WNK1 in the brain · 10

WNK1 → Cl, During, GABA, GABAA, In, KCC2, KCCs, NKCC1, SPAK/OSR1, Thus

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

kinase protein cl ions activity cell bp gene ion domain blood pressure chr nkcc1 human band function sodium potassium within

WNK1 relationships Subject–Predicate–Object triples

TTTA extracted 215 structured relationships around WNK1. Examples in this analysis include WNK1 → 2.7.11.1 → ↗ and WNK1 → Aliases → WNK1, HSAN2, HSN2, KDP, PPP1R167, PRKPSK, p65, WNK lysine deficient protein kinase 1. The table shows each extracted connection, where it came from and its confidence.

Subject	Predicate	Object	Confidence	Src
WNK1	2.7.11.1	↗	1.00	infobox
WNK1	Aliases	WNK1, HSAN2, HSN2, KDP, PPP1R167, PRKPSK, p65, WNK lysine deficient protein kinase 1	1.00	infobox
WNK1	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4PWN	1.00	infobox
WNK1	Band	12p13.33	1.00	infobox
WNK1	Band	6\|6 F1	1.00	infobox
WNK1	Bgee	internal globus pallidus	1.00	infobox
WNK1	Bgee	inferior ganglion of vagus nerve	1.00	infobox
WNK1	Bgee	subthalamic nucleus	1.00	infobox
WNK1	Bgee	dorsal motor nucleus of vagus nerve	1.00	infobox
WNK1	Bgee	external globus pallidus	1.00	infobox
WNK1	Bgee	optic nerve	1.00	infobox
WNK1	Bgee	pars reticulata	1.00	infobox
WNK1	Bgee	trabecular bone	1.00	infobox
WNK1	Bgee	pars compacta	1.00	infobox
WNK1	Bgee	inferior olivary nucleus	1.00	infobox
WNK1	Bgee	endothelial cell of lymphatic vessel	1.00	infobox
WNK1	Bgee	stroma of bone marrow	1.00	infobox
WNK1	Bgee	gastrula	1.00	infobox
WNK1	Bgee	right lung lobe	1.00	infobox
WNK1	Bgee	vestibular membrane of cochlear duct	1.00	infobox
WNK1	Bgee	saccule	1.00	infobox
WNK1	Bgee	primary oocyte	1.00	infobox
WNK1	Bgee	myocardium of ventricle	1.00	infobox
WNK1	Bgee	ciliary body	1.00	infobox
WNK1	Bgee	cardiac muscle tissue of left ventricle	1.00	infobox
WNK1	BioGPS	More reference expression data	1.00	infobox
WNK1	Chr.	Chromosome 12 (human)	1.00	infobox
WNK1	Chr.	Chromosome 6 (mouse)	1.00	infobox
WNK1	Databases	NCBI: entry; OMA: entry	1.00	infobox
WNK1	End	911,452 bp	1.00	infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around WNK1 bring nearby vocabulary together. In this analysis, examples include Kinase, Activity and Cl. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

WNK1
- Kinase
- Activity
- Cl
- Protein
- Function
- Also
- Ncc
- Sodium
- Activation
- Gene
- Phosphorylation
- Cell
wnk1
- Kinase
- Activity
- Cl
- Protein
- Function
- Also
- Ncc
- Sodium
- Activation
- Gene
- Phosphorylation
- Cell
serine-threonine protein kinase
- Kinase
- Protein
- Gene
- Activity
- Wnk
- Sodium
- Wnk1
- Lysine
- Also
- Domain
- Function
- Chromosome
blood pressure
- Pressure
- Fhht
- Ncc
- Sodium
- Activation
- Ion
- Cell
- Band
- Chromosome
- Expression
- Human
- Regulation
cell
- Ions
- Cl
- Chromosome
- Expression
- Human
- Regulation
- Bp
- Chr
- Potassium
- Pressure
- Sodium
- Function
protein
- Kinase
- Gene
- Wnk
- Sodium
- Chromosome
- Expression
- Human
- Regulation
- Wnk1
- Also
- Bp
- Chr
kinase
- Protein
- Activity
- Gene
- Wnk1
- Lysine
- Wnk
- Also
- Sodium
- Domain
- Function
- Chromosome
- Expression
mekk protein kinase
- Kinase
- Protein
- Gene
- Activity
- Wnk
- Sodium
- Wnk1
- Lysine
- Also
- Domain
- Function
- Chromosome

Connections between topic areas Semantic bridges

For WNK1, one of the stronger structural bridges in this analysis connects WNK1 with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

WNK1 — Function · splits 39 ⟂ 28

WNK1 — Structure · splits 57 ⟂ 10

WNK1 — Clinical significance · splits 57 ⟂ 10

WNK1 — Comparative genomics · splits 57 ⟂ 10

WNK1 — Overview · splits 59 ⟂ 8

Map overview Semantic statistics

WNK1

Nodes67

Edges66

Triples215

Avg. degree1.97

Density0.029851

Components1

Source & methodology

TTTA analyzes the structure around WNK1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Art, Function & Structure, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — WNK1 · EN edition · Analysis: TopicsToTalkAbout