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ROMK: Function, Clinical significance & Overview

The renal outer medullary potassium channel (ROMK) is an ATP-dependent potassium channel (Kir1.1) that transports potassium out of cells. It plays an important role in potassium recycling in the thick ascending limb (TAL) and potassium secretion in the cortical collecting duct (CCD) of the nephron. In humans, ROMK is encoded by the KCNJ1 (potassium…

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ROMK topic overview

The analysis highlights Function, Clinical significance and Overview as prominent areas in the source structure around ROMK.

Related topics
18
Source areas
3
Connected nodes
21
Extracted relationships
92
Concept neighborhoods
6
Bridge connections
21

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 11 topics
Overview · 6 topics
Clinical significance · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
KCNJ1, KIR1.1, ROMK, ROMK1, potassium voltage-gated channel subfamily J member 1, potassium inwardly rectifying channel subfamily J member 1
Band
11q24.3 · 9|9 A4
Bgee
renal medulla · kidney tubule · glomerulus · metanephric glomerulus · human kidney
BioGPS
n/a
Chr.
Chromosome 11 (human) · Chromosome 9 (mouse)
Databases
NCBI: entry; OMA: entry

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Clinical significance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How ROMK connects Entity context

The extracted context around ROMK shows recurring relationship patterns in the source. For example, ROMK → connecting tubule, convoluted tubule, cortical collecting duct, distal tubule, epithelium of colon, glomerulus, human kidney, inner renal medulla, inner stripe of outer renal medulla, kidney tubule, metanephric glomerulus, nucleus accumbens, olfactory epithelium, outer stripe of outer renal medulla, putamen, renal medulla, right kidney, tail of epididymis, testicle Another extracted example is ROMK → ATP binding, ATP-activated inward rectifier potassium channel activity, excretion, integral component of membrane, inward rectifier potassium channel activity, ion transport, membrane, nucleotide binding, phosphatidylinositol-4,5-bisphosphate binding, plasma membrane, potassium ion import across plasma membrane, potassium ion transport, regulation of ion transmembrane transport, voltage-gated ion channel activity, voltage-gated potassium channel complex. Use these groups to spot repeated connection types before inspecting the individual relationships.

ROMK

Top relations

Bgee · 19
ROMK → connecting tubule, convoluted tubule, cortical collecting duct, distal tubule, epithelium of colon, glomerulus, human kidney, inner renal medulla, inner stripe of outer renal medulla, kidney tubule, metanephric glomerulus, nucleus accumbens, olfactory epithelium, outer stripe of outer renal medulla, putamen, renal medulla, right kidney, tail of epididymis, testicle
RNA expression pattern · 19
ROMK → connecting tubule, convoluted tubule, cortical collecting duct, distal tubule, epithelium of colon, glomerulus, human kidney, inner renal medulla, inner stripe of outer renal medulla, kidney tubule, metanephric glomerulus, nucleus accumbens, olfactory epithelium, outer stripe of outer renal medulla, putamen, renal medulla, right kidney, tail of epididymis, testicle
Gene ontology · 15
ROMK → ATP binding, ATP-activated inward rectifier potassium channel activity, excretion, integral component of membrane, inward rectifier potassium channel activity, ion transport, membrane, nucleotide binding, phosphatidylinositol-4,5-bisphosphate binding, plasma membrane, potassium ion import across plasma membrane, potassium ion transport, regulation of ion transmembrane transport, voltage-gated ion channel activity, voltage-gated potassium channel complex
related to External links · 8
ROMK → Medicine, Medicine Medical Subject Headings, MeSH, National Library, NDI, ROMK1, This, United States National Library
related to Function · 6
ROMK → ATP, ATP-sensitive, It, Klotho, Potassium, The
related to Role in hypokalemia and magnesium deficiency · 5
ROMK → Conversely, In, Sgk1, The ROMK, This
Band · 2
ROMK → 11q24.3, 9|9 A4
Chr. · 2
ROMK → Chromosome 11 (human), Chromosome 9 (mouse)
End · 2
ROMK → 128,867,373 bp, 32,310,493 bp
Aliases · 1
ROMK → KCNJ1, KIR1.1, ROMK, ROMK1, potassium voltage-gated channel subfamily J member 1, potassium inwardly rectifying channel subfamily J member 1

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

potassium gene channel bp human chr band chromosome 11 magnesium role kcnj1 protein location encoded hypokalemia deficiency mouse renal outer

ROMK relationships Subject–Predicate–Object triples

TTTA extracted 92 structured relationships around ROMK. Examples in this analysis include ROMK → Aliases → KCNJ1, KIR1.1, ROMK, ROMK1, potassium voltage-gated channel subfamily J member 1, potassium inwardly rectifying channel subfamily J member 1 and ROMK → Band → 11q24.3. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
ROMKAliasesKCNJ1, KIR1.1, ROMK, ROMK1, potassium voltage-gated channel subfamily J member 1, potassium inwardly rectifying channel subfamily J member 11.00infobox
ROMKBand11q24.31.00infobox
ROMKBand9|9 A41.00infobox
ROMKBgeerenal medulla1.00infobox
ROMKBgeekidney tubule1.00infobox
ROMKBgeeglomerulus1.00infobox
ROMKBgeemetanephric glomerulus1.00infobox
ROMKBgeehuman kidney1.00infobox
ROMKBgeetesticle1.00infobox
ROMKBgeenucleus accumbens1.00infobox
ROMKBgeeepithelium of colon1.00infobox
ROMKBgeeputamen1.00infobox
ROMKBgeetail of epididymis1.00infobox
ROMKBgeeright kidney1.00infobox
ROMKBgeeinner renal medulla1.00infobox
ROMKBgeedistal tubule1.00infobox
ROMKBgeeinner stripe of outer renal medulla1.00infobox
ROMKBgeeolfactory epithelium1.00infobox
ROMKBgeeconnecting tubule1.00infobox
ROMKBgeeouter stripe of outer renal medulla1.00infobox
ROMKBgeeconvoluted tubule1.00infobox
ROMKBgeecortical collecting duct1.00infobox
ROMKBioGPSn/a1.00infobox
ROMKChr.Chromosome 11 (human)1.00infobox
ROMKChr.Chromosome 9 (mouse)1.00infobox
ROMKDatabasesNCBI: entry; OMA: entry1.00infobox
ROMKEnd128,867,373 bp1.00infobox
ROMKEnd32,310,493 bp1.00infobox
ROMKEnsemblENSG000001517041.00infobox
ROMKEntrez37581.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around ROMK bring nearby vocabulary together. In this analysis, examples include Member, Subfamily and Channels. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • potassium channel
    • Channel
    • Potassium
    • Kcnj1
    • Gene
    • Romk
    • Role
    • Cells
    • Function
    • Kir1
    • Member
    • Outer
    • Renal
  • gene
    • Kcnj1
    • Location
    • Chromosome
    • Bp
    • Chr
    • Human
    • End
    • Function
    • Member
    • Mouse
    • Potassium
    • Subfamily
  • function
    • Voltage-gated
    • Kcnj1
    • Location
    • Chromosome
    • External
    • Bp
    • Chr
    • Human
    • End
    • Kir1
    • Member
    • Mouse
  • cortical collecting duct
    • Collecting
    • Cortical
    • Duct
    • End
    • Function
    • Important
    • Mouse
    • Outer
    • Plays
    • Renal
    • Voltage-gated
    • Channels
  • ROMK
    • Member
    • Subfamily
    • Channels
    • Role
    • Magnesium
    • Gene
    • External
    • Function
    • Voltage-gated
    • Deficiency
    • Hypokalemia
    • Location
  • romk
    • Member
    • Subfamily
    • Channels
    • Role
    • Magnesium
    • Gene
    • External
    • Function
    • Voltage-gated
    • Deficiency
    • Hypokalemia
    • Location

Connections between topic areas Semantic bridges

For ROMK, one of the stronger structural bridges in this analysis connects ROMK with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
ROMKFunction · splits 10 ⟂ 12
ROMKOverview · splits 15 ⟂ 7

Map overview Semantic statistics

ROMK

Nodes22
Edges21
Triples92
Avg. degree1.91
Density0.090909
Components1

Source & methodology

TTTA analyzes the structure around ROMK to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Clinical significance & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — ROMK · EN edition · Analysis: TopicsToTalkAbout

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