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WAPAL

Wings apart-like protein homolog (WAPL) is a protein that in humans is encoded by the WAPL gene (previously WAPAL). WAPL is a key regulator of the Cohesin complex which mediates sister chromatid cohesion, homologous recombination and DNA looping. Cohesin is formed of SMC3, SMC1, RAD21 and either SA1 or SA2. Cohesin has a ring-like arrangement and it is…

Art, Interphase & Overview

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Interphase

NIPBLG1Sororin
3 related topics

Overview

ProteinGeneCohesinSister chromatid cohesionDNA looping
12 related topics

Prophase pathway

SGOL1PP2A
2 related topics

Key facts & relationships

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Aliases
WAPL, FOE, KIAA0261, WAPAL, WAPL cohesin release factor
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4K6J, 5HDT
Band
10q23.2 · 14|14 B
Bgee
secondary oocyte · sperm · ventricular zone · amniotic fluid · gonad
BioGPS
More reference expression data
Chr.
Chromosome 10 (human) · Chromosome 14 (mouse)

Topics to explore

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Overview

Interphase

Prophase pathway

Advanced semantic analysis

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Map overview Semantic statistics

WAPAL

Nodes21
Edges20
Triples86
Avg. degree1.9
Density0.095238
Components1

How this topic connects Entity context

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WAPAL

Top relations

Gene ontology · 25
WAPAL → cell cycle, cell division, chromatin, chromosome, chromosome, centromeric region, cohesin complex, cytoplasm, cytosol, meiotic chromosome segregation, mitotic cell cycle, mitotic sister chromatid cohesion, negative regulation of chromatin binding, negative regulation of DNA replication, negative regulation of sister chromatid cohesion, nucleoplasm, nucleus, positive regulation of fibroblast proliferation, protein binding, protein localization to chromatin, regulation of chromosome condensation
Bgee · 19
WAPAL → Achilles tendon, amniotic fluid, caput epididymis, genital tubercle, gonad, hair follicle, otolith organ, Paneth cell, primary oocyte, secondary oocyte, skin of hip, skin of thigh, sperm, tail of embryo, testicle, ureter, utricle, ventricular zone, zygote
RNA expression pattern · 19
WAPAL → Achilles tendon, amniotic fluid, caput epididymis, genital tubercle, gonad, hair follicle, otolith organ, Paneth cell, primary oocyte, secondary oocyte, skin of hip, skin of thigh, sperm, tail of embryo, testicle, ureter, utricle, ventricular zone, zygote
Band · 2
WAPAL → 10q23.2, 14|14 B
Chr. · 2
WAPAL → Chromosome 10 (human), Chromosome 14 (mouse)
End · 2
WAPAL → 34,469,940 bp, 86,521,792 bp
Aliases · 1
WAPAL → WAPL, FOE, KIAA0261, WAPAL, WAPL cohesin release factor
Available structures · 1
WAPAL → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4K6J, 5HDT
BioGPS · 1
WAPAL → More reference expression data
Databases · 1
WAPAL → NCBI: entry; OMA: entry

Important terminology Word statistics

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Important terminology

cohesin wapl dna chromosome sister bp complex chr human band gene 10 smc3 rad21 chromatid cohesion binding location opening interface

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
WAPALAliasesWAPL, FOE, KIAA0261, WAPAL, WAPL cohesin release factor1.00infobox
WAPALAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4K6J, 5HDT1.00infobox
WAPALBand10q23.21.00infobox
WAPALBand14|14 B1.00infobox
WAPALBgeesecondary oocyte1.00infobox
WAPALBgeesperm1.00infobox
WAPALBgeeventricular zone1.00infobox
WAPALBgeeamniotic fluid1.00infobox
WAPALBgeegonad1.00infobox
WAPALBgeetesticle1.00infobox
WAPALBgeeskin of thigh1.00infobox
WAPALBgeeAchilles tendon1.00infobox
WAPALBgeeskin of hip1.00infobox
WAPALBgeecaput epididymis1.00infobox
WAPALBgeezygote1.00infobox
WAPALBgeetail of embryo1.00infobox
WAPALBgeeotolith organ1.00infobox
WAPALBgeeutricle1.00infobox
WAPALBgeeprimary oocyte1.00infobox
WAPALBgeehair follicle1.00infobox
WAPALBgeePaneth cell1.00infobox
WAPALBgeeureter1.00infobox
WAPALBgeegenital tubercle1.00infobox
WAPALBioGPSMore reference expression data1.00infobox
WAPALChr.Chromosome 10 (human)1.00infobox
WAPALChr.Chromosome 14 (mouse)1.00infobox
WAPALDatabasesNCBI: entry; OMA: entry1.00infobox
WAPALEnd86,521,792 bp1.00infobox
WAPALEnd34,469,940 bp1.00infobox
WAPALEnsemblENSG000000626501.00infobox

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