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WAPAL: Art, Interphase & Overview

Wings apart-like protein homolog (WAPL) is a protein that in humans is encoded by the WAPL gene (previously WAPAL). WAPL is a key regulator of the Cohesin complex which mediates sister chromatid cohesion, homologous recombination and DNA looping. Cohesin is formed of SMC3, SMC1, RAD21 and either SA1 or SA2. Cohesin has a ring-like arrangement and it is…

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WAPAL topic overview

The analysis highlights Art, Interphase and Overview as prominent areas in the source structure around WAPAL.

Related topics
17
Source areas
3
Connected nodes
20
Extracted relationships
86
Concept neighborhoods
11
Bridge connections
20

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 12 topics
Interphase · 3 topics
Prophase pathway · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
WAPL, FOE, KIAA0261, WAPAL, WAPL cohesin release factor
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4K6J, 5HDT
Band
10q23.2 · 14|14 B
Bgee
secondary oocyte · sperm · ventricular zone · amniotic fluid · gonad
BioGPS
More reference expression data
Chr.
Chromosome 10 (human) · Chromosome 14 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Interphase

Prophase pathway

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How WAPAL connects Entity context

The extracted context around WAPAL shows recurring relationship patterns in the source. For example, WAPAL → cell cycle, cell division, chromatin, chromosome, chromosome, centromeric region, cohesin complex, cytoplasm, cytosol, meiotic chromosome segregation, mitotic cell cycle, mitotic sister chromatid cohesion, negative regulation of chromatin binding, negative regulation of DNA replication, negative regulation of sister chromatid cohesion, nucleoplasm, nucleus, positive regulation of fibroblast proliferation, protein binding, protein localization to chromatin, regulation of chromosome condensation Another extracted example is WAPAL → Achilles tendon, amniotic fluid, caput epididymis, genital tubercle, gonad, hair follicle, otolith organ, Paneth cell, primary oocyte, secondary oocyte, skin of hip, skin of thigh, sperm, tail of embryo, testicle, ureter, utricle, ventricular zone, zygote. Use these groups to spot repeated connection types before inspecting the individual relationships.

WAPAL

Top relations

Gene ontology · 25
WAPAL → cell cycle, cell division, chromatin, chromosome, chromosome, centromeric region, cohesin complex, cytoplasm, cytosol, meiotic chromosome segregation, mitotic cell cycle, mitotic sister chromatid cohesion, negative regulation of chromatin binding, negative regulation of DNA replication, negative regulation of sister chromatid cohesion, nucleoplasm, nucleus, positive regulation of fibroblast proliferation, protein binding, protein localization to chromatin, regulation of chromosome condensation
Bgee · 19
WAPAL → Achilles tendon, amniotic fluid, caput epididymis, genital tubercle, gonad, hair follicle, otolith organ, Paneth cell, primary oocyte, secondary oocyte, skin of hip, skin of thigh, sperm, tail of embryo, testicle, ureter, utricle, ventricular zone, zygote
RNA expression pattern · 19
WAPAL → Achilles tendon, amniotic fluid, caput epididymis, genital tubercle, gonad, hair follicle, otolith organ, Paneth cell, primary oocyte, secondary oocyte, skin of hip, skin of thigh, sperm, tail of embryo, testicle, ureter, utricle, ventricular zone, zygote
Band · 2
WAPAL → 10q23.2, 14|14 B
Chr. · 2
WAPAL → Chromosome 10 (human), Chromosome 14 (mouse)
End · 2
WAPAL → 34,469,940 bp, 86,521,792 bp
Aliases · 1
WAPAL → WAPL, FOE, KIAA0261, WAPAL, WAPL cohesin release factor
Available structures · 1
WAPAL → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4K6J, 5HDT
BioGPS · 1
WAPAL → More reference expression data
Databases · 1
WAPAL → NCBI: entry; OMA: entry

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

cohesin wapl dna chromosome sister bp complex chr human band gene 10 smc3 rad21 chromatid cohesion binding location opening interface

WAPAL relationships Subject–Predicate–Object triples

TTTA extracted 86 structured relationships around WAPAL. Examples in this analysis include WAPAL → Aliases → WAPL, FOE, KIAA0261, WAPAL, WAPL cohesin release factor and WAPAL → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4K6J, 5HDT. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
WAPALAliasesWAPL, FOE, KIAA0261, WAPAL, WAPL cohesin release factor1.00infobox
WAPALAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4K6J, 5HDT1.00infobox
WAPALBand10q23.21.00infobox
WAPALBand14|14 B1.00infobox
WAPALBgeesecondary oocyte1.00infobox
WAPALBgeesperm1.00infobox
WAPALBgeeventricular zone1.00infobox
WAPALBgeeamniotic fluid1.00infobox
WAPALBgeegonad1.00infobox
WAPALBgeetesticle1.00infobox
WAPALBgeeskin of thigh1.00infobox
WAPALBgeeAchilles tendon1.00infobox
WAPALBgeeskin of hip1.00infobox
WAPALBgeecaput epididymis1.00infobox
WAPALBgeezygote1.00infobox
WAPALBgeetail of embryo1.00infobox
WAPALBgeeotolith organ1.00infobox
WAPALBgeeutricle1.00infobox
WAPALBgeeprimary oocyte1.00infobox
WAPALBgeehair follicle1.00infobox
WAPALBgeePaneth cell1.00infobox
WAPALBgeeureter1.00infobox
WAPALBgeegenital tubercle1.00infobox
WAPALBioGPSMore reference expression data1.00infobox
WAPALChr.Chromosome 10 (human)1.00infobox
WAPALChr.Chromosome 14 (mouse)1.00infobox
WAPALDatabasesNCBI: entry; OMA: entry1.00infobox
WAPALEnd86,521,792 bp1.00infobox
WAPALEnd34,469,940 bp1.00infobox
WAPALEnsemblENSG000000626501.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around WAPAL bring nearby vocabulary together. In this analysis, examples include Pathway, Prophase and Search. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • gene
    • Location
    • Human
    • Bp
    • Chr
    • End
    • Mouse
    • Protein
    • Search
    • Wapal
    • Chromosome
    • Band
    • Wapl
  • cohesin
    • Dna
    • Wapl
    • Complex
    • Sister
    • Chromosome
    • Release
    • Cell
    • Forms
    • Loading
    • Pathway
    • Prophase
    • Releases
  • sister chromatid cohesion
    • Cohesion
    • Chromatid
    • Sister
    • Chromatids
    • Dna
    • Chromosome
    • Complex
    • Wapl
    • Cell
    • End
    • Loading
    • Mouse
  • dna looping
    • Wapl
    • Sister
    • Cell
    • Forms
    • Loading
    • Releases
    • Sororin
    • Interface
    • Opening
    • Chromosome
    • End
    • Mouse
  • protein
    • Gene
    • Cell
    • End
    • Loading
    • Mouse
    • Search
    • Wapal
    • Binding
    • Location
    • Band
    • Chromatid
    • Cohesion
  • WAPAL
    • Pathway
    • Prophase
    • Search
    • Location
    • Release
    • Human
    • Wapl
    • Bp
    • Chr
    • Chromosome
    • Cohesin
  • wapal
    • Pathway
    • Prophase
    • Search
    • Location
    • Release
    • Human
    • Wapl
    • Bp
    • Chr
    • Chromosome
    • Cohesin
  • prophase pathway
    • Prophase
    • Search
    • Wapal
    • Chromatids
    • Location
    • Release
    • Human
    • Bp
    • Chr
    • Sister
    • Wapl

Connections between topic areas Semantic bridges

For WAPAL, one of the stronger structural bridges in this analysis connects WAPAL with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
WAPALOverview · splits 8 ⟂ 13
WAPALInterphase · splits 17 ⟂ 4
WAPALProphase pathway · splits 18 ⟂ 3

Map overview Semantic statistics

WAPAL

Nodes21
Edges20
Triples86
Avg. degree1.9
Density0.095238
Components1

Source & methodology

TTTA analyzes the structure around WAPAL to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Art, Interphase & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — WAPAL · EN edition · Analysis: TopicsToTalkAbout

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