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RAD21

Double-strand-break repair protein rad21 homolog is a protein that in humans is encoded by the RAD21 gene. RAD21 (also known as Mcd1, Scc1, KIAA0078, NXP1, HR21), an essential gene, encodes a DNA double-strand break (DSB) repair protein that is evolutionarily conserved in all eukaryotes from budding yeast to humans. RAD21 protein is a structural…

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Function, Interactions & Structure

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Key facts & relationships

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Aliases
RAD21, CDLS4, HR21, HMCD1, NXP1, SCC1, hHR21, RAD21 cohesin complex component, MGS
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4PJU, 4PJW, 4PK7
Band
8q24.11 · 15|15 C
Bgee
ventricular zone · ganglionic eminence · superficial temporal artery · epithelium of nasopharynx · germinal epithelium
BioGPS
More reference expression data
Chr.
Chromosome 8 (human) · Chromosome 15 (mouse)

Topics to explore

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Overview

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Structure

Interactions

Function

Advanced semantic analysis

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Map overview Semantic statistics

Number of nodes, edges, triples, density and central hubs. Use it to gauge the size and connectivity of the map.

RAD21

Nodes59
Edges58
Triples172
Avg. degree1.97
Density0.033898
Components1

How this topic connects Entity context

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RAD21

Top relations

Gene ontology · 38
RAD21 → apoptotic process, cell cycle, cell division, cellular response to DNA damage stimulus, chromatin, chromatin binding, chromosome, chromosome segregation, chromosome, centromeric region, cohesin complex, condensed nuclear chromosome, cytoplasm, cytoskeleton, cytosol, DNA recombination, DNA repair, DNA-binding transcription activator activity, RNA polymerase II-specific, double-strand break repair, meiosis, meiotic cohesin complex
Bgee · 20
RAD21 → cerebellar vermis, dermis, epithelium of nasopharynx, ganglionic eminence, genital tubercle, germinal epithelium, Gonadal ridge, hand, human fetus, left lung lobe, lobe of cerebellum, medial ganglionic eminence, migratory enteric neural crest cell, pars compacta, pars reticulata, subthalamic nucleus, superficial temporal artery, tail of embryo, trabecular bone, ventricular zone
RNA expression pattern · 20
RAD21 → cerebellar vermis, dermis, epithelium of nasopharynx, ganglionic eminence, genital tubercle, germinal epithelium, Gonadal ridge, hand, human fetus, left lung lobe, lobe of cerebellum, medial ganglionic eminence, migratory enteric neural crest cell, pars compacta, pars reticulata, subthalamic nucleus, superficial temporal artery, tail of embryo, trabecular bone, ventricular zone
related to Function · 18
RAD21 → Also, As, CCCTC-binding, Cohesin, CREs, CTCF, CTCF-independent, DDR, DNA, Enhancers, Figure, In, KLF2, Nanog, Numerous, Oct4, Sox4, Thus
related to Structure · 18
RAD21 → C-terminus, Calcium-dependent, Calpain-1, Caspases, CT, Figure, Gekko Japonicus, Kleisins, N-terminus, NT, Orcinus Orca, SA1/SA2, SCC3, Separase, SMC1, SMC3, The STAG, These
related to Interactions · 17
RAD21 → According, Currently, Figure, NIPBL, PDS5A, PDS5B, SA1, SA1/SA2, SA2, SCC3, SMC1, SMC3, The, The C-terminal, The N-terminal, This, V-shaped SMC1
related to Discovery · 14
RAD21 → Birkenbihl, Bootsma, Hagemeijer, Hoeijmakers, In, Kanaar, McKay, Schizosaccharomyces, Separase, Smit, Spek, Subramani, The, Troelstra
Band · 2
RAD21 → 15|15 C, 8q24.11
Chr. · 2
RAD21 → Chromosome 15 (mouse), Chromosome 8 (human)
End · 2
RAD21 → 116,874,776 bp, 51,855,143 bp

Important terminology Word statistics

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Important terminology

cohesin gene human complex chromosome sister protein bp smc3 transcription cohesion also conserved dna chromatid sa1 sa2 chr band function

Entity relationships Subject–Predicate–Object triples

Extracted RDF-like relationships with confidence and source. The table includes structured facts and lower-confidence contextual relations.
SubjectPredicateObjectConfidenceSrc
RAD21AliasesRAD21, CDLS4, HR21, HMCD1, NXP1, SCC1, hHR21, RAD21 cohesin complex component, MGS1.00infobox
RAD21Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4PJU, 4PJW, 4PK71.00infobox
RAD21Band8q24.111.00infobox
RAD21Band15|15 C1.00infobox
RAD21Bgeeventricular zone1.00infobox
RAD21Bgeeganglionic eminence1.00infobox
RAD21Bgeesuperficial temporal artery1.00infobox
RAD21Bgeeepithelium of nasopharynx1.00infobox
RAD21Bgeegerminal epithelium1.00infobox
RAD21Bgeecerebellar vermis1.00infobox
RAD21Bgeepars reticulata1.00infobox
RAD21Bgeesubthalamic nucleus1.00infobox
RAD21Bgeepars compacta1.00infobox
RAD21Bgeetrabecular bone1.00infobox
RAD21BgeeGonadal ridge1.00infobox
RAD21Bgeehuman fetus1.00infobox
RAD21Bgeeleft lung lobe1.00infobox
RAD21Bgeehand1.00infobox
RAD21Bgeetail of embryo1.00infobox
RAD21Bgeedermis1.00infobox
RAD21Bgeemedial ganglionic eminence1.00infobox
RAD21Bgeemigratory enteric neural crest cell1.00infobox
RAD21Bgeelobe of cerebellum1.00infobox
RAD21Bgeegenital tubercle1.00infobox
RAD21BioGPSMore reference expression data1.00infobox
RAD21Chr.Chromosome 8 (human)1.00infobox
RAD21Chr.Chromosome 15 (mouse)1.00infobox
RAD21DatabasesNCBI: entry; OMA: entry1.00infobox
RAD21End116,874,776 bp1.00infobox
RAD21End51,855,143 bp1.00infobox

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