Research any topic before you write.

Find related topics. | Discover entities. | See connections. | Build a topical map.

RAD21: Function, Interactions & Structure

Double-strand-break repair protein rad21 homolog is a protein that in humans is encoded by the RAD21 gene. RAD21 (also known as Mcd1, Scc1, KIAA0078, NXP1, HR21), an essential gene, encodes a DNA double-strand break (DSB) repair protein that is evolutionarily conserved in all eukaryotes from budding yeast to humans. RAD21 protein is a structural…

Language: English [EN]

Use the mouse wheel or two fingers (on touchscreens) to zoom in and out of the map.

Map view:

Zoom: 100%

More settings

Connection length 100% Label size 100% Node size 100% Line width 100% Label width 100%

Export map as:

RAD21 topic overview

The analysis highlights Function, Interactions and Structure as prominent areas in the source structure around RAD21.

Related topics: 53
Source areas: 5
Connected nodes: 58
Extracted relationships: 172
Concept neighborhoods: 19
Bridge connections: 58

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 14 topics

Overview · 12 topics

Interactions · 10 topics

Structure · 9 topics

Discovery · 8 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases: RAD21, CDLS4, HR21, HMCD1, NXP1, SCC1, hHR21, RAD21 cohesin complex component, MGS
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4PJU, 4PJW, 4PK7
Band: 8q24.11 · 15|15 C
Bgee: ventricular zone · ganglionic eminence · superficial temporal artery · epithelium of nasopharynx · germinal epithelium
BioGPS: More reference expression data
Chr.: Chromosome 8 (human) · Chromosome 15 (mouse)

Suggested research paths

A focused starting point derived from the topic graph, ranked independently of the source article order.

Start with these areas

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Protein
Gene
DNA double-strand break DNA repair
Eukaryotes Eukaryote
Yeast
Humans Human
Cohesin
SMC1A
SMC3
STAG1
STAG2
Sister chromatid cohesion Establishment of sister chromatid cohesion

Discovery

Structure

Prokaryotic Prokaryote
Gekko Japonicus Schlegel's Japanese gecko
Orcinus Orca Orca
N-terminus
C-terminus
Calpain-1
Mitosis
Caspases Caspase
Apoptosis

Interactions

Sister chromatids
Coiled coil
NIPBL
Replication DNA replication
Transcription regulation Transcriptional regulation
RNA processing Post-transcriptional modification
Protein modification Post-translational modification
Degradation Proteolysis
Cytoskeleton
Motility

Function

S phase
Chromosome segregation
Gene expression
CTCF
Transcription factors Transcription factor
Chromatin
Enhancers Enhancer (genetics)
Insulators Insulator (genetics)
Meiosis
REC8
Homologous chromosomes Homologous chromosome
Cornelia de Lange syndrome
Chronic intestinal pseudo-obstruction
Mungan syndrome

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How RAD21 connects Entity context

The extracted context around RAD21 shows recurring relationship patterns in the source. For example, RAD21 → apoptotic process, cell cycle, cell division, cellular response to DNA damage stimulus, chromatin, chromatin binding, chromosome, chromosome segregation, chromosome, centromeric region, cohesin complex, condensed nuclear chromosome, cytoplasm, cytoskeleton, cytosol, DNA recombination, DNA repair, DNA-binding transcription activator activity, RNA polymerase II-specific, double-strand break repair, meiosis, meiotic cohesin complex Another extracted example is RAD21 → cerebellar vermis, dermis, epithelium of nasopharynx, ganglionic eminence, genital tubercle, germinal epithelium, Gonadal ridge, hand, human fetus, left lung lobe, lobe of cerebellum, medial ganglionic eminence, migratory enteric neural crest cell, pars compacta, pars reticulata, subthalamic nucleus, superficial temporal artery, tail of embryo, trabecular bone, ventricular zone. Use these groups to spot repeated connection types before inspecting the individual relationships.

RAD21

Top relations

Gene ontology · 38

RAD21 → apoptotic process, cell cycle, cell division, cellular response to DNA damage stimulus, chromatin, chromatin binding, chromosome, chromosome segregation, chromosome, centromeric region, cohesin complex, condensed nuclear chromosome, cytoplasm, cytoskeleton, cytosol, DNA recombination, DNA repair, DNA-binding transcription activator activity, RNA polymerase II-specific, double-strand break repair, meiosis, meiotic cohesin complex

Bgee · 20

RAD21 → cerebellar vermis, dermis, epithelium of nasopharynx, ganglionic eminence, genital tubercle, germinal epithelium, Gonadal ridge, hand, human fetus, left lung lobe, lobe of cerebellum, medial ganglionic eminence, migratory enteric neural crest cell, pars compacta, pars reticulata, subthalamic nucleus, superficial temporal artery, tail of embryo, trabecular bone, ventricular zone

RNA expression pattern · 20

related to Function · 18

RAD21 → Also, As, CCCTC-binding, Cohesin, CREs, CTCF, CTCF-independent, DDR, DNA, Enhancers, Figure, In, KLF2, Nanog, Numerous, Oct4, Sox4, Thus

related to Structure · 18

RAD21 → C-terminus, Calcium-dependent, Calpain-1, Caspases, CT, Figure, Gekko Japonicus, Kleisins, N-terminus, NT, Orcinus Orca, SA1/SA2, SCC3, Separase, SMC1, SMC3, The STAG, These

related to Interactions · 17

RAD21 → According, Currently, Figure, NIPBL, PDS5A, PDS5B, SA1, SA1/SA2, SA2, SCC3, SMC1, SMC3, The, The C-terminal, The N-terminal, This, V-shaped SMC1

related to Discovery · 14

RAD21 → Birkenbihl, Bootsma, Hagemeijer, Hoeijmakers, In, Kanaar, McKay, Schizosaccharomyces, Separase, Smit, Spek, Subramani, The, Troelstra

Band · 2

RAD21 → 15|15 C, 8q24.11

Chr. · 2

RAD21 → Chromosome 15 (mouse), Chromosome 8 (human)

End · 2

RAD21 → 116,874,776 bp, 51,855,143 bp

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

cohesin gene human complex chromosome sister protein bp smc3 transcription cohesion also conserved dna chromatid sa1 sa2 chr band function

RAD21 relationships Subject–Predicate–Object triples

TTTA extracted 172 structured relationships around RAD21. Examples in this analysis include RAD21 → Aliases → RAD21, CDLS4, HR21, HMCD1, NXP1, SCC1, hHR21, RAD21 cohesin complex component, MGS and RAD21 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4PJU, 4PJW, 4PK7. The table shows each extracted connection, where it came from and its confidence.

Subject	Predicate	Object	Confidence	Src
RAD21	Aliases	RAD21, CDLS4, HR21, HMCD1, NXP1, SCC1, hHR21, RAD21 cohesin complex component, MGS	1.00	infobox
RAD21	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4PJU, 4PJW, 4PK7	1.00	infobox
RAD21	Band	8q24.11	1.00	infobox
RAD21	Band	15\|15 C	1.00	infobox
RAD21	Bgee	ventricular zone	1.00	infobox
RAD21	Bgee	ganglionic eminence	1.00	infobox
RAD21	Bgee	superficial temporal artery	1.00	infobox
RAD21	Bgee	epithelium of nasopharynx	1.00	infobox
RAD21	Bgee	germinal epithelium	1.00	infobox
RAD21	Bgee	cerebellar vermis	1.00	infobox
RAD21	Bgee	pars reticulata	1.00	infobox
RAD21	Bgee	subthalamic nucleus	1.00	infobox
RAD21	Bgee	pars compacta	1.00	infobox
RAD21	Bgee	trabecular bone	1.00	infobox
RAD21	Bgee	Gonadal ridge	1.00	infobox
RAD21	Bgee	human fetus	1.00	infobox
RAD21	Bgee	left lung lobe	1.00	infobox
RAD21	Bgee	hand	1.00	infobox
RAD21	Bgee	tail of embryo	1.00	infobox
RAD21	Bgee	dermis	1.00	infobox
RAD21	Bgee	medial ganglionic eminence	1.00	infobox
RAD21	Bgee	migratory enteric neural crest cell	1.00	infobox
RAD21	Bgee	lobe of cerebellum	1.00	infobox
RAD21	Bgee	genital tubercle	1.00	infobox
RAD21	BioGPS	More reference expression data	1.00	infobox
RAD21	Chr.	Chromosome 8 (human)	1.00	infobox
RAD21	Chr.	Chromosome 15 (mouse)	1.00	infobox
RAD21	Databases	NCBI: entry; OMA: entry	1.00	infobox
RAD21	End	116,874,776 bp	1.00	infobox
RAD21	End	51,855,143 bp	1.00	infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around RAD21 bring nearby vocabulary together. In this analysis, examples include Cohesin, Complex and Smc3. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

RAD21
- Cohesin
- Complex
- Smc3
- Gene
- Component
- Conserved
- Also
- Human
- Chromosome
- Repair
- Segregation
- Smc1
rad21
- Cohesin
- Complex
- Smc3
- Gene
- Component
- Conserved
- Also
- Human
- Chromosome
- Repair
- Segregation
- Smc1
protein
- Repair
- Dna
- Cohesion
- Humans
- Regulation
- Component
- Gene
- Chromatid
- Conserved
- Function
- Chromosome
- Sister
gene
- Expression
- Human
- Location
- Chromosome
- Repair
- Bp
- Chr
- Protein
- Function
- Cohesin
- Transcription
- Humans
dna double-strand break
- Regulation
- Repair
- Protein
- Function
- Cohesion
- Chromosome
- Chromosomal
- Mitosis
- Segregation
- Complex
- Component
- Including
cohesin
- Complex
- Sister
- Component
- Chromatid
- Function
- Rad21
- Cohesion
- Expression
- Gene
- Dna
- Transcription
- Chromosomal
sister chromatid cohesion
- Sister
- Cohesion
- Complex
- Protein
- Segregation
- Dna
- Function
- Chromosome
- Cohesin
- Repair
- Two
- Chromosomal
chromosome 8
- Human
- Bp
- Function
- Location
- Band
- Segregation
- Gene
- Dna
- Cohesion
- Chromosomal
- Complex
- Mitosis

Connections between topic areas Semantic bridges

For RAD21, one of the stronger structural bridges in this analysis connects RAD21 with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

RAD21 — Function · splits 44 ⟂ 15

RAD21 — Overview · splits 46 ⟂ 13

RAD21 — Interactions · splits 48 ⟂ 11

RAD21 — Structure · splits 49 ⟂ 10

RAD21 — Discovery · splits 50 ⟂ 9

Map overview Semantic statistics

RAD21

Nodes59

Edges58

Triples172

Avg. degree1.97

Density0.033898

Components1

Source & methodology

TTTA analyzes the structure around RAD21 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Interactions & Structure, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — RAD21 · EN edition · Analysis: TopicsToTalkAbout

For writers, content strategists, SEOs, marketers and creators — from quick topic research to advanced semantic analysis.