Research any topic before you write.

Find related topics. | Discover entities. | See connections. | Build a topical map.

SMC1A

Structural maintenance of chromosomes protein 1A (SMC1A) is a protein that in humans is encoded by the SMC1A gene. SMC1A is a subunit of the cohesin complex which mediates sister chromatid cohesion, homologous recombination and DNA looping. In somatic cells, cohesin is formed of SMC1A, SMC3, RAD21 and either SA1 or SA2 whereas in meiosis, cohesin is…

Measurement, Function & Clinical significance

Use the mouse wheel or two fingers (on touchscreens) to zoom in and out of the map.

Research this topic

Explore the main themes, entities and connections around SMC1A. Start with the topic map, then use the sections below for research and deeper semantic analysis.

Explore this topic

Start with a few of the strongest sections from the source topic. These are research directions, not a list of keywords you must use.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
SMC1A, CDLS2, DXS423E, SB1.8, SMC1, SMC1L1, SMC1alpha, SMCB, structural maintenance of chromosomes 1A, EIEE85, DEE85
Available structures
Available structuresPDBOrtholog search: Q68EN4 PDBe Q68EN4 RCSB List of PDB id codes2WD5
Band
Xp11.22 · X|X F3
Bgee
sural nerve · trabecular bone · embryo · tendon of biceps brachii · jejunal mucosa
BioGPS
More reference expression data
Chr.
X chromosome (human) · X chromosome (mouse)

Topics to explore

Browse the full topic structure. Each item opens a new analysis centered on that subject.

Overview

Structure

Function

Clinical significance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

Map overview Semantic statistics

SMC1A

Nodes33
Edges32
Triples135
Avg. degree1.94
Density0.060606
Components1

How this topic connects Entity context

See the strongest relationship patterns around the current topic before diving into the raw triples.

SMC1A

Top relations

Gene ontology · 33
SMC1A → ATP binding, cell cycle, cell division, cellular response to DNA damage stimulus, chromatin binding, chromosome, chromosome organization, chromosome, centromeric region, cohesin complex, condensed nuclear chromosome, cytosol, DNA repair, kinetochore, mediator complex binding, meiosis, meiotic cohesin complex, mitotic sister chromatid cohesion, mitotic sister chromatid segregation, mitotic spindle pole, negative regulation of DNA endoreduplication
Bgee · 19
SMC1A → Achilles tendon, dermis, embryo, external carotid artery, fetal liver hematopoietic progenitor cell, genital tubercle, germinal epithelium, internal carotid artery, jejunal mucosa, maxillary prominence, mucosa of sigmoid colon, neural layer of retina, Rostral migratory stream, sural nerve, tail of embryo, tendon of biceps brachii, tibia, trabecular bone, ventricular zone
RNA expression pattern · 19
SMC1A → Achilles tendon, dermis, embryo, external carotid artery, fetal liver hematopoietic progenitor cell, genital tubercle, germinal epithelium, internal carotid artery, jejunal mucosa, maxillary prominence, mucosa of sigmoid colon, neural layer of retina, Rostral migratory stream, sural nerve, tail of embryo, tendon of biceps brachii, tibia, trabecular bone, ventricular zone
related to Function · 18
SMC1A → As, ATM, BRCA1, DNA, In, It, Most, Proper, RAE1, SMC, SMC1L2, SMC3, TAD, TADs, The, Therefore, This, X-chromosome
related to Genome instability and cancer · 14
SMC1A → ATM, ATR, BRCA1, Breast, CdLS, DNA, Finally, Furthermore, Indeed, It, S-phase, Ser957, Ser966, The
related to Cornelia de Lange syndrome · 6
SMC1A → CdLS, Cornelia, Lange, Pathogenic, Since SMC1A, The
Band · 2
SMC1A → Xp11.22, X|X F3
Chr. · 2
SMC1A → X chromosome (human), X chromosome (mouse)
End · 2
SMC1A → 150,845,690 bp, 53,422,728 bp
is a · 2
SMC1A → member of the SMC protein family, subunit of the cohesin complex which mediates sister chromatid cohesion

Important terminology Word statistics

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

cohesin gene dna chromosome protein bp chromosomes chr human band repair smc3 maintenance cancer structural complex sister cohesion segregation cdls

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
SMC1AAliasesSMC1A, CDLS2, DXS423E, SB1.8, SMC1, SMC1L1, SMC1alpha, SMCB, structural maintenance of chromosomes 1A, EIEE85, DEE851.00infobox
SMC1AAvailable structuresAvailable structuresPDBOrtholog search: Q68EN4 PDBe Q68EN4 RCSB List of PDB id codes2WD51.00infobox
SMC1ABandXp11.221.00infobox
SMC1ABandX|X F31.00infobox
SMC1ABgeesural nerve1.00infobox
SMC1ABgeetrabecular bone1.00infobox
SMC1ABgeeembryo1.00infobox
SMC1ABgeetendon of biceps brachii1.00infobox
SMC1ABgeejejunal mucosa1.00infobox
SMC1ABgeegerminal epithelium1.00infobox
SMC1ABgeeventricular zone1.00infobox
SMC1ABgeemucosa of sigmoid colon1.00infobox
SMC1ABgeetibia1.00infobox
SMC1ABgeeAchilles tendon1.00infobox
SMC1ABgeegenital tubercle1.00infobox
SMC1ABgeeRostral migratory stream1.00infobox
SMC1ABgeetail of embryo1.00infobox
SMC1ABgeeneural layer of retina1.00infobox
SMC1ABgeefetal liver hematopoietic progenitor cell1.00infobox
SMC1ABgeeexternal carotid artery1.00infobox
SMC1ABgeeinternal carotid artery1.00infobox
SMC1ABgeedermis1.00infobox
SMC1ABgeemaxillary prominence1.00infobox
SMC1ABioGPSMore reference expression data1.00infobox
SMC1AChr.X chromosome (human)1.00infobox
SMC1AChr.X chromosome (mouse)1.00infobox
SMC1ADatabasesNCBI: entry; OMA: entry1.00infobox
SMC1AEnd53,422,728 bp1.00infobox
SMC1AEnd150,845,690 bp1.00infobox
SMC1AEnsemblENSG000000725011.00infobox

Related concept clusters Concept neighborhoods

These clusters group vocabulary that occurs around closely connected concepts in the source material.

    Connections between topic areas Semantic bridges

    Bridges can reveal useful research angles that are easy to miss in a flat list of related terms.

    Min side: 3
    For writers, content strategists, SEOs, marketers and creators — from quick topic research to advanced semantic analysis.