SMC1A

Use the mouse wheel or two fingers (on touchscreens) to zoom in and out of the map.

Map view:

Zoom: 100%

More settings

Connection length 100% Label size 100% Node size 100% Line width 100% Label width 100%

Export map as:

SMC1A topic overview

The analysis highlights Measurement, Function and Clinical significance as prominent areas in the source structure around SMC1A.

Related topics: 28
Source areas: 4
Connected nodes: 32
Extracted relationships: 135
Concept neighborhoods: 15
Bridge connections: 32

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 13 topics

Function · 9 topics

Clinical significance · 4 topics

Structure · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases: SMC1A, CDLS2, DXS423E, SB1.8, SMC1, SMC1L1, SMC1alpha, SMCB, structural maintenance of chromosomes 1A, EIEE85, DEE85
Available structures: Available structuresPDBOrtholog search: Q68EN4 PDBe Q68EN4 RCSB List of PDB id codes2WD5
Band: Xp11.22 · X|X F3
Bgee: sural nerve · trabecular bone · embryo · tendon of biceps brachii · jejunal mucosa
BioGPS: More reference expression data
Chr.: X chromosome (human) · X chromosome (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Protein
Gene
Cohesin
Sister chromatid cohesion Establishment of sister chromatid cohesion
DNA looping Topologically associating domain
SMC3
RAD21
SA1 STAG1
SA2 STAG2
SMC1B
REC8
SA3 STAG3
SMC protein family SMC protein

Structure

Walker B motif Walker motifs
ABC-type ATPase ATP-binding cassette transporter

Function

Sister chromatids Sister chromatid
Chromosomes Chromosome
SMC1L2 SMC1L2?action=edit&redlink=1
BRCA1
Phosphorylated
ATM Ataxia telangiectasia mutated
DNA repair
X-chromosome
X inactivation

Clinical significance

Cornelia de Lange syndrome (CdLS) Cornelia de Lange syndrome
Dysmorphic features Dysmorphic feature
Global developmental delay
Intellectual disability

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How SMC1A connects Entity context

The extracted context around SMC1A shows recurring relationship patterns in the source. For example, SMC1A → ATP binding, cell cycle, cell division, cellular response to DNA damage stimulus, chromatin binding, chromosome, chromosome organization, chromosome, centromeric region, cohesin complex, condensed nuclear chromosome, cytosol, DNA repair, kinetochore, mediator complex binding, meiosis, meiotic cohesin complex, mitotic sister chromatid cohesion, mitotic sister chromatid segregation, mitotic spindle pole, negative regulation of DNA endoreduplication Another extracted example is SMC1A → Achilles tendon, dermis, embryo, external carotid artery, fetal liver hematopoietic progenitor cell, genital tubercle, germinal epithelium, internal carotid artery, jejunal mucosa, maxillary prominence, mucosa of sigmoid colon, neural layer of retina, Rostral migratory stream, sural nerve, tail of embryo, tendon of biceps brachii, tibia, trabecular bone, ventricular zone. Use these groups to spot repeated connection types before inspecting the individual relationships.

Top relations

Gene ontology · 33

SMC1A → ATP binding, cell cycle, cell division, cellular response to DNA damage stimulus, chromatin binding, chromosome, chromosome organization, chromosome, centromeric region, cohesin complex, condensed nuclear chromosome, cytosol, DNA repair, kinetochore, mediator complex binding, meiosis, meiotic cohesin complex, mitotic sister chromatid cohesion, mitotic sister chromatid segregation, mitotic spindle pole, negative regulation of DNA endoreduplication

Bgee · 19

SMC1A → Achilles tendon, dermis, embryo, external carotid artery, fetal liver hematopoietic progenitor cell, genital tubercle, germinal epithelium, internal carotid artery, jejunal mucosa, maxillary prominence, mucosa of sigmoid colon, neural layer of retina, Rostral migratory stream, sural nerve, tail of embryo, tendon of biceps brachii, tibia, trabecular bone, ventricular zone

RNA expression pattern · 19

related to Function · 18

SMC1A → As, ATM, BRCA1, DNA, In, It, Most, Proper, RAE1, SMC, SMC1L2, SMC3, TAD, TADs, The, Therefore, This, X-chromosome

related to Genome instability and cancer · 14

SMC1A → ATM, ATR, BRCA1, Breast, CdLS, DNA, Finally, Furthermore, Indeed, It, S-phase, Ser957, Ser966, The

related to Cornelia de Lange syndrome · 6

SMC1A → CdLS, Cornelia, Lange, Pathogenic, Since SMC1A, The

Band · 2

SMC1A → Xp11.22, X|X F3

Chr. · 2

SMC1A → X chromosome (human), X chromosome (mouse)

End · 2

SMC1A → 150,845,690 bp, 53,422,728 bp

is a · 2

SMC1A → member of the SMC protein family, subunit of the cohesin complex which mediates sister chromatid cohesion

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

cohesin gene dna chromosome protein bp chromosomes chr human band repair smc3 maintenance cancer structural complex sister cohesion segregation cdls

SMC1A relationships Subject–Predicate–Object triples

TTTA extracted 135 structured relationships around SMC1A. Examples in this analysis include SMC1A → Aliases → SMC1A, CDLS2, DXS423E, SB1.8, SMC1, SMC1L1, SMC1alpha, SMCB, structural maintenance of chromosomes 1A, EIEE85, DEE85 and SMC1A → Available structures → Available structuresPDBOrtholog search: Q68EN4 PDBe Q68EN4 RCSB List of PDB id codes2WD5. The table shows each extracted connection, where it came from and its confidence.

Subject	Predicate	Object	Confidence	Src
SMC1A	Aliases	SMC1A, CDLS2, DXS423E, SB1.8, SMC1, SMC1L1, SMC1alpha, SMCB, structural maintenance of chromosomes 1A, EIEE85, DEE85	1.00	infobox
SMC1A	Available structures	Available structuresPDBOrtholog search: Q68EN4 PDBe Q68EN4 RCSB List of PDB id codes2WD5	1.00	infobox
SMC1A	Band	Xp11.22	1.00	infobox
SMC1A	Band	X\|X F3	1.00	infobox
SMC1A	Bgee	sural nerve	1.00	infobox
SMC1A	Bgee	trabecular bone	1.00	infobox
SMC1A	Bgee	embryo	1.00	infobox
SMC1A	Bgee	tendon of biceps brachii	1.00	infobox
SMC1A	Bgee	jejunal mucosa	1.00	infobox
SMC1A	Bgee	germinal epithelium	1.00	infobox
SMC1A	Bgee	ventricular zone	1.00	infobox
SMC1A	Bgee	mucosa of sigmoid colon	1.00	infobox
SMC1A	Bgee	tibia	1.00	infobox
SMC1A	Bgee	Achilles tendon	1.00	infobox
SMC1A	Bgee	genital tubercle	1.00	infobox
SMC1A	Bgee	Rostral migratory stream	1.00	infobox
SMC1A	Bgee	tail of embryo	1.00	infobox
SMC1A	Bgee	neural layer of retina	1.00	infobox
SMC1A	Bgee	fetal liver hematopoietic progenitor cell	1.00	infobox
SMC1A	Bgee	external carotid artery	1.00	infobox
SMC1A	Bgee	internal carotid artery	1.00	infobox
SMC1A	Bgee	dermis	1.00	infobox
SMC1A	Bgee	maxillary prominence	1.00	infobox
SMC1A	BioGPS	More reference expression data	1.00	infobox
SMC1A	Chr.	X chromosome (human)	1.00	infobox
SMC1A	Chr.	X chromosome (mouse)	1.00	infobox
SMC1A	Databases	NCBI: entry; OMA: entry	1.00	infobox
SMC1A	End	53,422,728 bp	1.00	infobox
SMC1A	End	150,845,690 bp	1.00	infobox
SMC1A	Ensembl	ENSG00000072501	1.00	infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around SMC1A bring nearby vocabulary together. In this analysis, examples include Dna, Cancer and Cohesin. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

SMC1A
- Dna
- Cancer
- Cohesin
- Variants
- Cdls
- Chromosome
- Gene
- Cycle
- Function
- Pole
- Cell
- Spindle
smc1a
- Dna
- Cancer
- Cohesin
- Variants
- Cdls
- Chromosome
- Gene
- Cycle
- Function
- Pole
- Cell
- Spindle
protein
- Encoded
- Smc
- Gene
- Complex
- End
- Structural
- Repair
- Smc1a
- Dna
- 1a
- Humans
- Meiosis
gene
- Maintenance
- Location
- Human
- Smc
- Structural
- Bp
- Chr
- Chromosome
- Mouse
- Protein
- Cohesin
- Cycle
cohesin
- Chromatid
- Cohesion
- Complex
- Sister
- Meiosis
- Cycle
- Dna
- Expression
- Function
- Gene
- Pole
- Smc1a
sister chromatid cohesion
- Cohesion
- Sister
- Chromatid
- Complex
- Cell
- Cohesin
- Segregation
- Meiosis
- Mouse
- Cycle
- Dna
- Expression
dna looping
- Repair
- Cycle
- Cell
- Segregation
- Smc1a
- Chromosome
- End
- Sister
- Protein
- Gene
- Humans
- Meiosis
smc protein family
- Family
- Smc
- Encoded
- Humans
- Gene
- Complex
- End
- Mouse
- Structural
- Repair
- Cycle
- Expression

Connections between topic areas Semantic bridges

For SMC1A, one of the stronger structural bridges in this analysis connects SMC1A with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

SMC1A — Overview · splits 19 ⟂ 14

SMC1A — Function · splits 23 ⟂ 10

SMC1A — Clinical significance · splits 28 ⟂ 5

SMC1A — Structure · splits 30 ⟂ 3

Map overview Semantic statistics

SMC1A

Nodes33

Edges32

Triples135

Avg. degree1.94

Density0.060606

Components1

Source & methodology

TTTA analyzes the structure around SMC1A to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Measurement, Function & Clinical significance, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — SMC1A · EN edition · Analysis: TopicsToTalkAbout