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Cohesin subunit SA-2 (SA2) is a protein that in humans is encoded by the STAG2 gene. SA2 is a subunit of the Cohesin complex which mediates sister chromatid cohesion, homologous recombination and DNA looping. In somatic cells cohesin is formed of SMC3, SMC1, RAD21 and either SA1 or SA2 whereas in meiosis, cohesin is formed of SMC3, SMC1B, REC8 and SA3.
The analysis highlights Measurement, Overview and Function as prominent areas in the source structure around STAG2.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
The extracted context around STAG2 shows recurring relationship patterns in the source. For example, STAG2 → Achilles tendon, atrioventricular valve, carotid body, cartilage tissue, Epithelium of choroid plexus, epithelium of colon, hair follicle, lacrimal gland, lactiferous duct, left lung lobe, lower lobe of lung, medial ganglionic eminence, mucosa of paranasal sinus, parotid gland, sural nerve, trabecular bone, ventricular zone, vestibular membrane of cochlear duct, vestibular sensory epithelium Another extracted example is STAG2 → cell cycle, cell division, chromatin, chromatin binding, chromosome, chromosome segregation, chromosome, centromeric region, cohesin complex, cytosol, meiosis, membrane, mitotic spindle pole, negative regulation of DNA endoreduplication, nuclear matrix, nucleoplasm, nucleus, protein binding, regulation of mitotic spindle assembly, sister chromatid cohesion. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
gene cohesin sa2 bp chromosome protein complex chr human band dna cohesion cancers subunit structure mutations sister location smc3 rad21
TTTA extracted 105 structured relationships around STAG2. Examples in this analysis include STAG2 → Aliases → STAG2, SA-2, SA2, SCC3B, bA517O1.1, stromal antigen 2, NEDXCF, MKMS, HPE13 and STAG2 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4PJU, 4PJW, 4PK7. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| STAG2 | Aliases | STAG2, SA-2, SA2, SCC3B, bA517O1.1, stromal antigen 2, NEDXCF, MKMS, HPE13 | 1.00 | infobox |
| STAG2 | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4PJU, 4PJW, 4PK7 | 1.00 | infobox |
| STAG2 | Band | Xq25 | 1.00 | infobox |
| STAG2 | Band | X|X A4 | 1.00 | infobox |
| STAG2 | Bgee | mucosa of paranasal sinus | 1.00 | infobox |
| STAG2 | Bgee | Achilles tendon | 1.00 | infobox |
| STAG2 | Bgee | sural nerve | 1.00 | infobox |
| STAG2 | Bgee | Epithelium of choroid plexus | 1.00 | infobox |
| STAG2 | Bgee | trabecular bone | 1.00 | infobox |
| STAG2 | Bgee | lower lobe of lung | 1.00 | infobox |
| STAG2 | Bgee | lactiferous duct | 1.00 | infobox |
| STAG2 | Bgee | epithelium of colon | 1.00 | infobox |
| STAG2 | Bgee | cartilage tissue | 1.00 | infobox |
| STAG2 | Bgee | ventricular zone | 1.00 | infobox |
| STAG2 | Bgee | vestibular membrane of cochlear duct | 1.00 | infobox |
| STAG2 | Bgee | left lung lobe | 1.00 | infobox |
| STAG2 | Bgee | parotid gland | 1.00 | infobox |
| STAG2 | Bgee | atrioventricular valve | 1.00 | infobox |
| STAG2 | Bgee | carotid body | 1.00 | infobox |
| STAG2 | Bgee | medial ganglionic eminence | 1.00 | infobox |
| STAG2 | Bgee | lacrimal gland | 1.00 | infobox |
| STAG2 | Bgee | hair follicle | 1.00 | infobox |
| STAG2 | Bgee | vestibular sensory epithelium | 1.00 | infobox |
| STAG2 | BioGPS | More reference expression data | 1.00 | infobox |
| STAG2 | Chr. | X chromosome (human) | 1.00 | infobox |
| STAG2 | Chr. | X chromosome (mouse) | 1.00 | infobox |
| STAG2 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| STAG2 | End | 124,422,664 bp | 1.00 | infobox |
| STAG2 | End | 41,366,062 bp | 1.00 | infobox |
| STAG2 | Ensembl | ENSG00000101972 | 1.00 | infobox |
The concept neighborhoods around STAG2 bring nearby vocabulary together. In this analysis, examples include Gene, Mutations and Cancer. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For STAG2, one of the stronger structural bridges in this analysis connects STAG2 with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around STAG2 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Measurement, Overview & Function, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — STAG2 · EN edition · Analysis: TopicsToTalkAbout