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STAG2

Cohesin subunit SA-2 (SA2) is a protein that in humans is encoded by the STAG2 gene. SA2 is a subunit of the Cohesin complex which mediates sister chromatid cohesion, homologous recombination and DNA looping. In somatic cells cohesin is formed of SMC3, SMC1, RAD21 and either SA1 or SA2 whereas in meiosis, cohesin is formed of SMC3, SMC1B, REC8 and SA3.

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Aliases
STAG2, SA-2, SA2, SCC3B, bA517O1.1, stromal antigen 2, NEDXCF, MKMS, HPE13
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4PJU, 4PJW, 4PK7
Band
Xq25 · X|X A4
Bgee
mucosa of paranasal sinus · Achilles tendon · sural nerve · Epithelium of choroid plexus · trabecular bone
BioGPS
More reference expression data
Chr.
X chromosome (human) · X chromosome (mouse)

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Map overview Semantic statistics

STAG2

Nodes23
Edges22
Triples105
Avg. degree1.91
Density0.086957
Components1

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STAG2

Top relations

Bgee · 19
STAG2 → Achilles tendon, atrioventricular valve, carotid body, cartilage tissue, Epithelium of choroid plexus, epithelium of colon, hair follicle, lacrimal gland, lactiferous duct, left lung lobe, lower lobe of lung, medial ganglionic eminence, mucosa of paranasal sinus, parotid gland, sural nerve, trabecular bone, ventricular zone, vestibular membrane of cochlear duct, vestibular sensory epithelium
Gene ontology · 19
STAG2 → cell cycle, cell division, chromatin, chromatin binding, chromosome, chromosome segregation, chromosome, centromeric region, cohesin complex, cytosol, meiosis, membrane, mitotic spindle pole, negative regulation of DNA endoreduplication, nuclear matrix, nucleoplasm, nucleus, protein binding, regulation of mitotic spindle assembly, sister chromatid cohesion
RNA expression pattern · 19
STAG2 → Achilles tendon, atrioventricular valve, carotid body, cartilage tissue, Epithelium of choroid plexus, epithelium of colon, hair follicle, lacrimal gland, lactiferous duct, left lung lobe, lower lobe of lung, medial ganglionic eminence, mucosa of paranasal sinus, parotid gland, sural nerve, trabecular bone, ventricular zone, vestibular membrane of cochlear duct, vestibular sensory epithelium
related to Function · 11
STAG2 → Another, Cohesion, DNA, RAD21, SA2, SMC1, SMC1A, SMC3, STAG1, The, This
related to Structure · 7
STAG2 → EMA, Jeavons, JS, Of, This, X-linked, Xq25
related to Mutations · 6
STAG2 → Cohesion, Mutations, One, SA2, STAG, The
Band · 2
STAG2 → Xq25, X|X A4
Chr. · 2
STAG2 → X chromosome (human), X chromosome (mouse)
End · 2
STAG2 → 124,422,664 bp, 41,366,062 bp
Aliases · 1
STAG2 → STAG2, SA-2, SA2, SCC3B, bA517O1.1, stromal antigen 2, NEDXCF, MKMS, HPE13

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Important terminology

gene cohesin sa2 bp chromosome protein complex chr human band dna cohesion cancers subunit structure mutations sister location smc3 rad21

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
STAG2AliasesSTAG2, SA-2, SA2, SCC3B, bA517O1.1, stromal antigen 2, NEDXCF, MKMS, HPE131.00infobox
STAG2Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4PJU, 4PJW, 4PK71.00infobox
STAG2BandXq251.00infobox
STAG2BandX|X A41.00infobox
STAG2Bgeemucosa of paranasal sinus1.00infobox
STAG2BgeeAchilles tendon1.00infobox
STAG2Bgeesural nerve1.00infobox
STAG2BgeeEpithelium of choroid plexus1.00infobox
STAG2Bgeetrabecular bone1.00infobox
STAG2Bgeelower lobe of lung1.00infobox
STAG2Bgeelactiferous duct1.00infobox
STAG2Bgeeepithelium of colon1.00infobox
STAG2Bgeecartilage tissue1.00infobox
STAG2Bgeeventricular zone1.00infobox
STAG2Bgeevestibular membrane of cochlear duct1.00infobox
STAG2Bgeeleft lung lobe1.00infobox
STAG2Bgeeparotid gland1.00infobox
STAG2Bgeeatrioventricular valve1.00infobox
STAG2Bgeecarotid body1.00infobox
STAG2Bgeemedial ganglionic eminence1.00infobox
STAG2Bgeelacrimal gland1.00infobox
STAG2Bgeehair follicle1.00infobox
STAG2Bgeevestibular sensory epithelium1.00infobox
STAG2BioGPSMore reference expression data1.00infobox
STAG2Chr.X chromosome (human)1.00infobox
STAG2Chr.X chromosome (mouse)1.00infobox
STAG2DatabasesNCBI: entry; OMA: entry1.00infobox
STAG2End124,422,664 bp1.00infobox
STAG2End41,366,062 bp1.00infobox
STAG2EnsemblENSG000001019721.00infobox

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