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STAG2: Measurement, Overview & Function

Cohesin subunit SA-2 (SA2) is a protein that in humans is encoded by the STAG2 gene. SA2 is a subunit of the Cohesin complex which mediates sister chromatid cohesion, homologous recombination and DNA looping. In somatic cells cohesin is formed of SMC3, SMC1, RAD21 and either SA1 or SA2 whereas in meiosis, cohesin is formed of SMC3, SMC1B, REC8 and SA3.

Language: English [EN]
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STAG2 topic overview

The analysis highlights Measurement, Overview and Function as prominent areas in the source structure around STAG2.

Related topics
19
Source areas
3
Connected nodes
22
Extracted relationships
105
Concept neighborhoods
15
Bridge connections
22

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 14 topics
Function · 3 topics
Structure · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
STAG2, SA-2, SA2, SCC3B, bA517O1.1, stromal antigen 2, NEDXCF, MKMS, HPE13
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4PJU, 4PJW, 4PK7
Band
Xq25 · X|X A4
Bgee
mucosa of paranasal sinus · Achilles tendon · sural nerve · Epithelium of choroid plexus · trabecular bone
BioGPS
More reference expression data
Chr.
X chromosome (human) · X chromosome (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Structure

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How STAG2 connects Entity context

The extracted context around STAG2 shows recurring relationship patterns in the source. For example, STAG2 → Achilles tendon, atrioventricular valve, carotid body, cartilage tissue, Epithelium of choroid plexus, epithelium of colon, hair follicle, lacrimal gland, lactiferous duct, left lung lobe, lower lobe of lung, medial ganglionic eminence, mucosa of paranasal sinus, parotid gland, sural nerve, trabecular bone, ventricular zone, vestibular membrane of cochlear duct, vestibular sensory epithelium Another extracted example is STAG2 → cell cycle, cell division, chromatin, chromatin binding, chromosome, chromosome segregation, chromosome, centromeric region, cohesin complex, cytosol, meiosis, membrane, mitotic spindle pole, negative regulation of DNA endoreduplication, nuclear matrix, nucleoplasm, nucleus, protein binding, regulation of mitotic spindle assembly, sister chromatid cohesion. Use these groups to spot repeated connection types before inspecting the individual relationships.

STAG2

Top relations

Bgee · 19
STAG2 → Achilles tendon, atrioventricular valve, carotid body, cartilage tissue, Epithelium of choroid plexus, epithelium of colon, hair follicle, lacrimal gland, lactiferous duct, left lung lobe, lower lobe of lung, medial ganglionic eminence, mucosa of paranasal sinus, parotid gland, sural nerve, trabecular bone, ventricular zone, vestibular membrane of cochlear duct, vestibular sensory epithelium
Gene ontology · 19
STAG2 → cell cycle, cell division, chromatin, chromatin binding, chromosome, chromosome segregation, chromosome, centromeric region, cohesin complex, cytosol, meiosis, membrane, mitotic spindle pole, negative regulation of DNA endoreduplication, nuclear matrix, nucleoplasm, nucleus, protein binding, regulation of mitotic spindle assembly, sister chromatid cohesion
RNA expression pattern · 19
STAG2 → Achilles tendon, atrioventricular valve, carotid body, cartilage tissue, Epithelium of choroid plexus, epithelium of colon, hair follicle, lacrimal gland, lactiferous duct, left lung lobe, lower lobe of lung, medial ganglionic eminence, mucosa of paranasal sinus, parotid gland, sural nerve, trabecular bone, ventricular zone, vestibular membrane of cochlear duct, vestibular sensory epithelium
related to Function · 11
STAG2 → Another, Cohesion, DNA, RAD21, SA2, SMC1, SMC1A, SMC3, STAG1, The, This
related to Structure · 7
STAG2 → EMA, Jeavons, JS, Of, This, X-linked, Xq25
related to Mutations · 6
STAG2 → Cohesion, Mutations, One, SA2, STAG, The
Band · 2
STAG2 → Xq25, X|X A4
Chr. · 2
STAG2 → X chromosome (human), X chromosome (mouse)
End · 2
STAG2 → 124,422,664 bp, 41,366,062 bp
Aliases · 1
STAG2 → STAG2, SA-2, SA2, SCC3B, bA517O1.1, stromal antigen 2, NEDXCF, MKMS, HPE13

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

gene cohesin sa2 bp chromosome protein complex chr human band dna cohesion cancers subunit structure mutations sister location smc3 rad21

STAG2 relationships Subject–Predicate–Object triples

TTTA extracted 105 structured relationships around STAG2. Examples in this analysis include STAG2 → Aliases → STAG2, SA-2, SA2, SCC3B, bA517O1.1, stromal antigen 2, NEDXCF, MKMS, HPE13 and STAG2 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4PJU, 4PJW, 4PK7. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
STAG2AliasesSTAG2, SA-2, SA2, SCC3B, bA517O1.1, stromal antigen 2, NEDXCF, MKMS, HPE131.00infobox
STAG2Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4PJU, 4PJW, 4PK71.00infobox
STAG2BandXq251.00infobox
STAG2BandX|X A41.00infobox
STAG2Bgeemucosa of paranasal sinus1.00infobox
STAG2BgeeAchilles tendon1.00infobox
STAG2Bgeesural nerve1.00infobox
STAG2BgeeEpithelium of choroid plexus1.00infobox
STAG2Bgeetrabecular bone1.00infobox
STAG2Bgeelower lobe of lung1.00infobox
STAG2Bgeelactiferous duct1.00infobox
STAG2Bgeeepithelium of colon1.00infobox
STAG2Bgeecartilage tissue1.00infobox
STAG2Bgeeventricular zone1.00infobox
STAG2Bgeevestibular membrane of cochlear duct1.00infobox
STAG2Bgeeleft lung lobe1.00infobox
STAG2Bgeeparotid gland1.00infobox
STAG2Bgeeatrioventricular valve1.00infobox
STAG2Bgeecarotid body1.00infobox
STAG2Bgeemedial ganglionic eminence1.00infobox
STAG2Bgeelacrimal gland1.00infobox
STAG2Bgeehair follicle1.00infobox
STAG2Bgeevestibular sensory epithelium1.00infobox
STAG2BioGPSMore reference expression data1.00infobox
STAG2Chr.X chromosome (human)1.00infobox
STAG2Chr.X chromosome (mouse)1.00infobox
STAG2DatabasesNCBI: entry; OMA: entry1.00infobox
STAG2End124,422,664 bp1.00infobox
STAG2End41,366,062 bp1.00infobox
STAG2EnsemblENSG000001019721.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around STAG2 bring nearby vocabulary together. In this analysis, examples include Gene, Mutations and Cancer. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • STAG2
    • Gene
    • Mutations
    • Cancer
    • Frequently
    • Cancers
    • Dna
    • Function
    • Search
    • Expression
    • Location
    • Subunit
    • Cohesion
  • stag2
    • Gene
    • Mutations
    • Cancer
    • Frequently
    • Cancers
    • Dna
    • Function
    • Search
    • Expression
    • Location
    • Subunit
    • Cohesion
  • protein
    • Stag2
    • Sa2
    • Cancer
    • Expression
    • Dna
    • Mutations
    • Gene
    • Chromatid
    • End
    • Function
    • Meiosis
    • Mouse
  • gene
    • Stag2
    • Chromosome
    • Expression
    • Location
    • Human
    • Bp
    • Chr
    • Protein
    • Sa2
    • End
    • Function
    • Mouse
  • cohesin
    • Complex
    • Sa2
    • Subunit
    • Structure
    • Chromatid
    • Meiosis
    • Sister
    • Rad21
    • Smc3
    • Cohesion
    • Dna
    • Stag2
  • sister chromatid cohesion
    • Sister
    • Dna
    • Cohesion
    • Complex
    • Expression
    • End
    • Function
    • Meiosis
    • Mouse
    • Search
    • Cohesin
    • Sa2
  • structure
    • Complex
    • Function
    • Search
    • Location
    • Cohesin
    • Sa2
    • Human
    • Bp
    • Chr
    • Chromosome
    • Chromatid
    • End
  • dna looping
    • Sister
    • Expression
    • Protein
    • Stag2
    • Sa2
    • Either
    • End
    • Function
    • Meiosis
    • Mouse
    • Search
    • Smc1

Connections between topic areas Semantic bridges

For STAG2, one of the stronger structural bridges in this analysis connects STAG2 with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
STAG2Overview · splits 8 ⟂ 15
STAG2Function · splits 19 ⟂ 4
STAG2Structure · splits 20 ⟂ 3

Map overview Semantic statistics

STAG2

Nodes23
Edges22
Triples105
Avg. degree1.91
Density0.086957
Components1

Source & methodology

TTTA analyzes the structure around STAG2 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Measurement, Overview & Function, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — STAG2 · EN edition · Analysis: TopicsToTalkAbout

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