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Vicriviroc

Vicriviroc, previously named SCH 417690 and SCH-D, is a pyrimidine CCR5 entry inhibitor of HIV-1. It was developed by the pharmaceutical company Schering-Plough. Merck decided to not pursue regulatory approval for use in treatment-experienced patients because the drug did not meet primary efficacy endpoints in late stage trials. Clinical trials continue…

Companies, HIV-1 background & Clinical trials

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HIV-1 background

HIVT-cellsMacrophagesGp120Gp41
11 related topics

Clinical trials

RNAR5B.i.d.
3 related topics

SCH-C and vicriviroc

QTcHuman ether-a-go-go-related gene
2 related topics

Concerns surrounding CCR5 antagonists

Maraviroc
1 related topics

Topics to explore

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Overview

HIV-1 background

SCH-C and vicriviroc

Clinical trials

Concerns surrounding CCR5 antagonists

Advanced semantic analysis

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Map overview Semantic statistics

Vicriviroc

Nodes30
Edges29
Triples55
Avg. degree1.93
Density0.066667
Components1

How this topic connects Entity context

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Vicriviroc

Top relations

related to Method of action · 15
Vicriviroc → Additionally, Binding, CCR5, E238, I198, It, Other, Specific, Specifically, TM3, TM5, TM6, TM7, Y108, Y251
related to SCH-C and vicriviroc · 11
Vicriviroc → CCR5, HIV-1, However, In, QT, QTc, SAR, SCH, SCH-C, Schering-Plough, When
related to Concerns surrounding CCR5 antagonists · 10
Vicriviroc → Available, CCR5, CXCR4, HIV, HIV-1, However, In, Studies, Two, V3
related to Clinical trials · 8
Vicriviroc → Currently, HIV RNA, HIV-1, HIV-infected, II, Phase II, R5-infected, The
related to background · 5
Vicriviroc → CCR5, HIV, HIV-1, However, The
instance of · 1
Vicriviroc → CCR5 inhibitors

Important terminology Word statistics

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Important terminology

ccr5 hiv-1 gp120 coreceptor virus patients hiv trials viral cell two may however antagonists gp41 cxcr4 target one entry clinical

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
vicrivirocinstance ofCCR5 inhibitors0.80text
as well as other entry inhibitors of HIV-1instance ofCCR5 inhibitors0.80text
inhibit the initial stages of the virus life cycle.HIV-1 entryHIV binds toinstance ofCCR5 inhibitors0.80text
fuses with the target T-cells or macrophages with the help of gp120instance ofCCR5 inhibitors0.80text
gp41instance ofCCR5 inhibitors0.80text
the only two proteins that are currently known to be exhibited on the surface of the viral envelopeinstance ofCCR5 inhibitors0.80text
Vicrivirocrelated to backgroundThe0.60section
Vicrivirocrelated to backgroundHIV0.60section
Vicrivirocrelated to backgroundHowever0.60section
Vicrivirocrelated to backgroundCCR50.60section
Vicrivirocrelated to backgroundHIV-10.60section
Vicrivirocrelated to Clinical trialsCurrently0.60section

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