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Daptomycin

Daptomycin, sold under the brand name Cubicin among others, is a lipopeptide antibiotic used in the treatment of systemic and life-threatening infections caused by Gram-positive organisms.

History & Applications

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Explore the main themes, entities and connections around Daptomycin. Start with the topic map, then use the sections below for research and deeper semantic analysis.

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Key facts & relationships

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AHFS/Drugs.com
Monograph
ATC code
J01XX09 (WHO)
Bioavailability
n/a
CAS Number
103060-53-3 Y
ChEBI
CHEBI:600103 N
ChEMBL
ChEMBL508162 N

Topics to explore

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Overview

Medical uses

Adverse effects

Pharmacology

Microbiology

Daptomycin resistance

Efficacy

Biosynthesis

History

Advanced semantic analysis

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Map overview Semantic statistics

Daptomycin

Nodes69
Edges68
Triples105
Avg. degree1.97
Density0.028986
Components1

How this topic connects Entity context

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Daptomycin

Top relations

related to history · 19
Daptomycin → Chiron Corporation, Company, Cubicin, Cubicin RF, Cubist Pharmaceuticals, Drug Administration, Eli Lilly, EU, FDA, Food, Gram-positive, I/II, In July, Lilly, LY, Novartis, September, Streptomyces, The
related to Biosynthesis · 15
Daptomycin → Biosynthesis, C10, Finally, Kyn, L-3-methylglutamic, L-kynurenine, N-terminal, N-terminal Trp, NRPS, Streptomyces, The, The N-terminus, The NRPS, These, Two
related to Daptomycin resistance · 10
Daptomycin → Data, Europe, GRE, It, Korea, Lechuguilla Cave, Paenibacillus, Taiwan, The, United States
related to Microbiology · 8
Daptomycin → Borrelia, Daptomycin's, Gram-positive, GRE, In, It, Membrane, Staphylococcus
related to External links · 7
Daptomycin → Archived, August, Drug Administration, FDA, FDA Rationale, Food, Recognition Decision
related to Medical uses · 7
Daptomycin → FDA, Gram-positive, In, It, March, September, United States
related to Efficacy · 5
Daptomycin → CI, Detroit, MIC, Michigan, MRSA
related to Mechanism of action · 5
Daptomycin → DNA, It, RNA, The, This
Legal status · 4
Daptomycin → AU: S4 (Prescription only), EU: Rx-only, UK: POM (Prescription only), US: ℞-only
has effect · 2
Daptomycin → Cardiovascular, Common

Important terminology Word statistics

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Important terminology

acid domain amino nrps figure acids tryptophan lipopeptide fda patients peptide next catalyzes drug cubicin antibiotic citation needed two decanoic

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
DaptomycinAHFS/Drugs.comMonograph1.00infobox
DaptomycinATC codeJ01XX09 (WHO)1.00infobox
DaptomycinBioavailabilityn/a1.00infobox
DaptomycinCAS Number103060-53-3 Y1.00infobox
DaptomycinChEBICHEBI:600103 N1.00infobox
DaptomycinChEMBLChEMBL508162 N1.00infobox
DaptomycinChemSpider10482098 Y1.00infobox
DaptomycinCompTox Dashboard (EPA)DTXSID10410091.00infobox
DaptomycinDrugBankDB00080 Y1.00infobox
DaptomycinECHA InfoCard100.116.0651.00infobox
DaptomycinElimination half-life7–11 hours (up to 28 hours in renal impairment)1.00infobox
DaptomycinExcretionKidney (78%; primarily as unchanged drug); faeces (5.7%)1.00infobox
DaptomycinFormulaC72H101N17O261.00infobox
DaptomycinKEGGD01080 N1.00infobox
DaptomycinLegal statusAU: S4 (Prescription only)1.00infobox
DaptomycinLegal statusUK: POM (Prescription only)1.00infobox
DaptomycinLegal statusUS: ℞-only1.00infobox
DaptomycinLegal statusEU: Rx-only1.00infobox
DaptomycinLicense dataUS DailyMed: Daptomycin1.00infobox
DaptomycinMolar mass1620.693 g·mol−11.00infobox
DaptomycinOther namesLY 1460321.00infobox
DaptomycinPregnancy categoryAU: B11.00infobox
DaptomycinProtein binding90–95%1.00infobox
DaptomycinPubChem CID161296291.00infobox
DaptomycinRoutes of administrationIntravenous1.00infobox
DaptomycinTrade namesCubicin, Cubicin RF, Dapzura RT1.00infobox
DaptomycinUNIINWQ5N31VKK1.00infobox

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