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Daptomycin: History & Applications

Daptomycin, sold under the brand name Cubicin among others, is a lipopeptide antibiotic used in the treatment of systemic and life-threatening infections caused by Gram-positive organisms.

Language: English [EN]
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Daptomycin topic overview

The analysis highlights History and Applications as prominent areas in the source structure around Daptomycin.

Related topics
59
Source areas
9
Connected nodes
68
Extracted relationships
105
Concept neighborhoods
14
Bridge connections
68

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Adverse effects · 13 topics
History · 10 topics
Efficacy · 7 topics
Microbiology · 7 topics
Pharmacology · 6 topics
Biosynthesis · 5 topics
Medical uses · 5 topics
Overview · 4 topics
Daptomycin resistance · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

AHFS/Drugs.com
Monograph
ATC code
J01XX09 (WHO)
Bioavailability
n/a
CAS Number
103060-53-3 Y
ChEBI
CHEBI:600103 N
ChEMBL
ChEMBL508162 N

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Medical uses

Adverse effects

Pharmacology

Microbiology

Daptomycin resistance

Efficacy

Biosynthesis

History

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Daptomycin connects Entity context

The extracted context around Daptomycin shows recurring relationship patterns in the source. For example, Daptomycin → Chiron Corporation, Company, Cubicin, Cubicin RF, Cubist Pharmaceuticals, Drug Administration, Eli Lilly, EU, FDA, Food, Gram-positive, I/II, In July, Lilly, LY, Novartis, September, Streptomyces, The Another extracted example is Daptomycin → Biosynthesis, C10, Finally, Kyn, L-3-methylglutamic, L-kynurenine, N-terminal, N-terminal Trp, NRPS, Streptomyces, The, The N-terminus, The NRPS, These, Two. Use these groups to spot repeated connection types before inspecting the individual relationships.

Daptomycin

Top relations

related to history · 19
Daptomycin → Chiron Corporation, Company, Cubicin, Cubicin RF, Cubist Pharmaceuticals, Drug Administration, Eli Lilly, EU, FDA, Food, Gram-positive, I/II, In July, Lilly, LY, Novartis, September, Streptomyces, The
related to Biosynthesis · 15
Daptomycin → Biosynthesis, C10, Finally, Kyn, L-3-methylglutamic, L-kynurenine, N-terminal, N-terminal Trp, NRPS, Streptomyces, The, The N-terminus, The NRPS, These, Two
related to Daptomycin resistance · 10
Daptomycin → Data, Europe, GRE, It, Korea, Lechuguilla Cave, Paenibacillus, Taiwan, The, United States
related to Microbiology · 8
Daptomycin → Borrelia, Daptomycin's, Gram-positive, GRE, In, It, Membrane, Staphylococcus
related to External links · 7
Daptomycin → Archived, August, Drug Administration, FDA, FDA Rationale, Food, Recognition Decision
related to Medical uses · 7
Daptomycin → FDA, Gram-positive, In, It, March, September, United States
related to Efficacy · 5
Daptomycin → CI, Detroit, MIC, Michigan, MRSA
related to Mechanism of action · 5
Daptomycin → DNA, It, RNA, The, This
Legal status · 4
Daptomycin → AU: S4 (Prescription only), EU: Rx-only, UK: POM (Prescription only), US: ℞-only
has effect · 2
Daptomycin → Cardiovascular, Common

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

acid domain amino nrps figure acids tryptophan lipopeptide fda patients peptide next catalyzes drug cubicin antibiotic citation needed two decanoic

Daptomycin relationships Subject–Predicate–Object triples

TTTA extracted 105 structured relationships around Daptomycin. Examples in this analysis include Daptomycin → AHFS/Drugs.com → Monograph and Daptomycin → ATC code → J01XX09 (WHO). The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
DaptomycinAHFS/Drugs.comMonograph1.00infobox
DaptomycinATC codeJ01XX09 (WHO)1.00infobox
DaptomycinBioavailabilityn/a1.00infobox
DaptomycinCAS Number103060-53-3 Y1.00infobox
DaptomycinChEBICHEBI:600103 N1.00infobox
DaptomycinChEMBLChEMBL508162 N1.00infobox
DaptomycinChemSpider10482098 Y1.00infobox
DaptomycinCompTox Dashboard (EPA)DTXSID10410091.00infobox
DaptomycinDrugBankDB00080 Y1.00infobox
DaptomycinECHA InfoCard100.116.0651.00infobox
DaptomycinElimination half-life7–11 hours (up to 28 hours in renal impairment)1.00infobox
DaptomycinExcretionKidney (78%; primarily as unchanged drug); faeces (5.7%)1.00infobox
DaptomycinFormulaC72H101N17O261.00infobox
DaptomycinKEGGD01080 N1.00infobox
DaptomycinLegal statusAU: S4 (Prescription only)1.00infobox
DaptomycinLegal statusUK: POM (Prescription only)1.00infobox
DaptomycinLegal statusUS: ℞-only1.00infobox
DaptomycinLegal statusEU: Rx-only1.00infobox
DaptomycinLicense dataUS DailyMed: Daptomycin1.00infobox
DaptomycinMolar mass1620.693 g·mol−11.00infobox
DaptomycinOther namesLY 1460321.00infobox
DaptomycinPregnancy categoryAU: B11.00infobox
DaptomycinProtein binding90–95%1.00infobox
DaptomycinPubChem CID161296291.00infobox
DaptomycinRoutes of administrationIntravenous1.00infobox
DaptomycinTrade namesCubicin, Cubicin RF, Dapzura RT1.00infobox
DaptomycinUNIINWQ5N31VKK1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Daptomycin bring nearby vocabulary together. In this analysis, examples include Antibiotic, Citation and Lipopeptide. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Daptomycin
    • Antibiotic
    • Citation
    • Lipopeptide
    • Needed
    • Patients
    • Acid
    • Nrps
    • Resistance
    • Therapy
    • Genes
    • Two
    • Figure
  • daptomycin
    • Antibiotic
    • Citation
    • Lipopeptide
    • Needed
    • Patients
    • Acid
    • Nrps
    • Resistance
    • Therapy
    • Genes
    • Two
    • Figure
  • daptomycin resistance
    • Antibiotic
    • Citation
    • Lipopeptide
    • Needed
    • Patients
    • Acid
    • Aureus
    • Biosynthesis
    • Caused
    • Gram-positive
    • Nrps
    • Protein
  • condensation domain
    • Tryptophan
    • Catalyzes
    • Peptide
    • Figure
    • Gene
    • Next
    • Decanoic
    • First
    • Modules
    • Chain
    • Protein
    • Domain
  • biosynthesis
    • Decanoic
    • Genes
    • Nrps
    • Aureus
    • Caused
    • Gram-positive
    • Protein
    • Cubicin
    • Gene
    • Resistance
    • Acid
    • Drug
  • tryptophan
    • Decanoic
    • Acid
    • Condensation
    • First
    • Amino
    • Catalyzes
    • Peptide
    • Acids
    • Figure
    • Nrps
    • Biosynthesis
    • Domain
  • lipopeptide
    • Genes
    • Nrps
    • Biosynthesis
    • Gram-positive
    • Treatment
    • Gene
    • Chain
    • Citation
    • Module
    • Modules
    • Needed
    • Two
  • antibiotic
    • Lipopeptide
    • Figure
    • Daptomycin
    • Caused
    • Gram-positive
    • Treatment
    • Cubicin
    • Resistance
    • Chain
    • Nrps
    • Amino
    • Acid

Connections between topic areas Semantic bridges

For Daptomycin, one of the stronger structural bridges in this analysis connects Daptomycin with Adverse effects. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
DaptomycinAdverse effects · splits 55 ⟂ 14
DaptomycinHistory · splits 58 ⟂ 11
DaptomycinMicrobiology · splits 61 ⟂ 8
DaptomycinEfficacy · splits 61 ⟂ 8
DaptomycinPharmacology · splits 62 ⟂ 7
DaptomycinMedical uses · splits 63 ⟂ 6
DaptomycinBiosynthesis · splits 63 ⟂ 6
DaptomycinOverview · splits 64 ⟂ 5
DaptomycinDaptomycin resistance · splits 66 ⟂ 3

Map overview Semantic statistics

Daptomycin

Nodes69
Edges68
Triples105
Avg. degree1.97
Density0.028986
Components1

Source & methodology

TTTA analyzes the structure around Daptomycin to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History & Applications, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Daptomycin · EN edition · Analysis: TopicsToTalkAbout

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