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TRPM8: Regions, Ligands & Function

Transient receptor potential cation channel subfamily M (melastatin) member 8 (TRPM8), also known as the cold and menthol receptor 1 (CMR1), is a protein that in humans is encoded by the TRPM8 gene. The TRPM8 channel is the primary molecular transducer of cold somatosensation in humans. In addition, mints can desensitize a region through the activation…

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TRPM8 topic overview

The analysis highlights Regions, Ligands and Function as prominent areas in the source structure around TRPM8.

Related topics
92
Source areas
6
Connected nodes
98
Extracted relationships
160
Concept neighborhoods
20
Bridge connections
98

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Ligands · 36 topics
Function · 19 topics
Properties · 14 topics
Clinical significance · 13 topics
Structure · 7 topics
Overview · 3 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
TRPM8, LTRPC6, TRPP8, transient receptor potential cation channel subfamily M member 8, trp-p8, LTrpC-6
Band
2q37.1 · 1|1 D
Bgee
right lobe of liver · prostate · testicle · pancreatic ductal cell · trigeminal ganglion
BioGPS
More reference expression data
Chr.
Chromosome 2 (human) · Chromosome 1 (mouse)
Databases
NCBI: entry; OMA: entry

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure

Function

Properties

Ligands

Clinical significance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How TRPM8 connects Entity context

The extracted context around TRPM8 shows recurring relationship patterns in the source. For example, TRPM8 → calcium channel activity, calcium ion transmembrane transport, calcium ion transport, cation transport, cellular calcium ion homeostasis, detection of temperature stimulus, endoplasmic reticulum, endoplasmic reticulum membrane, external side of plasma membrane, integral component of membrane, ion channel activity, ion transport, membrane, membrane raft, plasma membrane, protein binding, protein homodimerization activity, protein homotetramerization, protein homotrimerization, response to cold Another extracted example is TRPM8 → amniotic fluid, cerebellar cortex, endometrium, gonad, islet of Langerhans, left testis, pancreatic ductal cell, prostate, right lobe of liver, seminiferous tubule, spermatid, spermatocyte, spinal ganglia, testicle, trigeminal ganglion. Use these groups to spot repeated connection types before inspecting the individual relationships.

TRPM8

Top relations

Gene ontology · 25
TRPM8 → calcium channel activity, calcium ion transmembrane transport, calcium ion transport, cation transport, cellular calcium ion homeostasis, detection of temperature stimulus, endoplasmic reticulum, endoplasmic reticulum membrane, external side of plasma membrane, integral component of membrane, ion channel activity, ion transport, membrane, membrane raft, plasma membrane, protein binding, protein homodimerization activity, protein homotetramerization, protein homotrimerization, response to cold
Bgee · 15
TRPM8 → amniotic fluid, cerebellar cortex, endometrium, gonad, islet of Langerhans, left testis, pancreatic ductal cell, prostate, right lobe of liver, seminiferous tubule, spermatid, spermatocyte, spinal ganglia, testicle, trigeminal ganglion
RNA expression pattern · 15
TRPM8 → amniotic fluid, cerebellar cortex, endometrium, gonad, islet of Langerhans, left testis, pancreatic ductal cell, prostate, right lobe of liver, seminiferous tubule, spermatid, spermatocyte, spinal ganglia, testicle, trigeminal ganglion
related to Agonists · 14
TRPM8 → Ca2, Coolact, Cooling Agent, Experimentally, Frescolat MGA, Frescolat ML, HEK293, In, M8-Ag, Of, PMD, Traditionally, WS-12/Acoltremon, WS-23
related to Role in the nervous system · 12
TRPM8 → Application, Central, DRG, In, It, McKemy, The, This, TRP, TRPs, TRPV1, Using
related to Sensitization · 11
TRPM8 → Activation, An, L-menthol, Numerous, The, They, This, To, TRPM8-receptor, TRPM8-sensitization, Wasner
related to Antagonists · 7
TRPM8 → AcidCannabidivarinCannabigerolic, AMG-333RQ-00434739RQ-00203078PF-05105679, BCTC, M8 BAMTB5-benzyloxytryptamineAnandamideN-Arachidonoyl, M8-An, S1-S4, These
related to Desensitization · 7
TRPM8 → As, Ca2, Dessirier, Ethanol, Mutagenesis, Testing, The
related to Function · 7
TRPM8 → A-delta, Ca2, CPS-369, Na, The, The TRPM8, WS-12
related to Role in cancer · 7
TRPM8 → As, By, Ca2, ER, Immunofluorescence, LNCaP, This

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

menthol cold receptor channel response agonists receptors protein prostate human bp gene also pain capsaicin cancer chr band stimuli sensitization

TRPM8 relationships Subject–Predicate–Object triples

TTTA extracted 160 structured relationships around TRPM8. Examples in this analysis include TRPM8 → Aliases → TRPM8, LTRPC6, TRPP8, transient receptor potential cation channel subfamily M member 8, trp-p8, LTrpC-6 and TRPM8 → Band → 2q37.1. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
TRPM8AliasesTRPM8, LTRPC6, TRPP8, transient receptor potential cation channel subfamily M member 8, trp-p8, LTrpC-61.00infobox
TRPM8Band2q37.11.00infobox
TRPM8Band1|1 D1.00infobox
TRPM8Bgeeright lobe of liver1.00infobox
TRPM8Bgeeprostate1.00infobox
TRPM8Bgeetesticle1.00infobox
TRPM8Bgeepancreatic ductal cell1.00infobox
TRPM8Bgeetrigeminal ganglion1.00infobox
TRPM8Bgeeamniotic fluid1.00infobox
TRPM8Bgeeislet of Langerhans1.00infobox
TRPM8Bgeegonad1.00infobox
TRPM8Bgeeendometrium1.00infobox
TRPM8Bgeeleft testis1.00infobox
TRPM8Bgeeseminiferous tubule1.00infobox
TRPM8Bgeespinal ganglia1.00infobox
TRPM8Bgeespermatid1.00infobox
TRPM8Bgeecerebellar cortex1.00infobox
TRPM8Bgeespermatocyte1.00infobox
TRPM8BioGPSMore reference expression data1.00infobox
TRPM8Chr.Chromosome 2 (human)1.00infobox
TRPM8Chr.Chromosome 1 (mouse)1.00infobox
TRPM8DatabasesNCBI: entry; OMA: entry1.00infobox
TRPM8End234,019,522 bp1.00infobox
TRPM8End88,317,015 bp1.00infobox
TRPM8EnsemblENSG000001444811.00infobox
TRPM8Entrez790541.00infobox
TRPM8External IDsOMIM: 606678; MGI: 2181435; GeneCards: TRPM81.00infobox
TRPM8Gene location (Human)Gene location (Human)Chr.Chromosome 2 (human)Band2q37.1Start233,917,373 bpEnd234,019,522 bp1.00infobox
TRPM8Gene location (Mouse)Gene location (Mouse)Chr.Chromosome 1 (mouse)Band1|1 DStart88,205,383 bpEnd88,317,015 bp1.00infobox
TRPM8Gene ontologyprotein homodimerization activity1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around TRPM8 bring nearby vocabulary together. In this analysis, examples include Shown, Cells and Trpv1. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • transient receptor potential cation channel
    • Gene
    • Also
    • Channel
    • Potential
    • Menthol
    • Cation
    • Chromosome
    • Function
    • Bp
    • Chr
    • Human
    • Receptors
  • menthol
    • Receptor
    • Agonists
    • Receptors
    • Capsaicin
    • Response
    • Icilin
    • Trpm8
    • Irritant
    • Sensory
    • Temperatures
    • Ca2
    • Stimuli
  • agonists
    • Icilin
    • Menthol
    • Temperatures
    • Used
    • Receptor
    • Cold
    • Channel
    • Trpm8
    • Antagonists
    • Cation
    • Chromosome
    • Function
  • ion channel
    • Potential
    • Gene
    • Also
    • Protein
    • Trpm8
    • Menthol
    • Chromosome
    • Function
    • Receptor
    • Cold
    • Bp
    • Chr
  • transient receptor potential channel
    • Channel
    • Potential
    • Menthol
    • Cation
    • Gene
    • Also
    • Receptors
    • System
    • Trpm8
    • Protein
    • Chromosome
    • Function
  • receptor
    • Menthol
    • Receptors
    • System
    • Trpm8
    • Antagonists
    • Trpv1
    • Shown
    • Ca2
    • Capsaicin
    • Also
    • Stimuli
    • Agonists
  • cold
    • Trpm8
    • Temperatures
    • Menthol
    • Primary
    • Sensation
    • Sensory
    • Response
    • Pain
    • Protein
    • Molecular
    • Gene
    • Stimuli
  • protein
    • Function
    • Trpm8
    • Sensory
    • Cell
    • Gene
    • Human
    • Response
    • Prostate
    • Band
    • Chromosome
    • Bp
    • Chr

Connections between topic areas Semantic bridges

For TRPM8, one of the stronger structural bridges in this analysis connects TRPM8 with Ligands. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
TRPM8Ligands · splits 62 ⟂ 37
TRPM8Function · splits 79 ⟂ 20
TRPM8Properties · splits 84 ⟂ 15
TRPM8Clinical significance · splits 85 ⟂ 14
TRPM8Structure · splits 91 ⟂ 8
TRPM8Overview · splits 95 ⟂ 4

Map overview Semantic statistics

TRPM8

Nodes99
Edges98
Triples160
Avg. degree1.98
Density0.020202
Components1

Source & methodology

TTTA analyzes the structure around TRPM8 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Regions, Ligands & Function, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — TRPM8 · EN edition · Analysis: TopicsToTalkAbout

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