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TRPM8

Transient receptor potential cation channel subfamily M (melastatin) member 8 (TRPM8), also known as the cold and menthol receptor 1 (CMR1), is a protein that in humans is encoded by the TRPM8 gene. The TRPM8 channel is the primary molecular transducer of cold somatosensation in humans. In addition, mints can desensitize a region through the activation…

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Aliases
TRPM8, LTRPC6, TRPP8, transient receptor potential cation channel subfamily M member 8, trp-p8, LTrpC-6
Band
2q37.1 · 1|1 D
Bgee
right lobe of liver · prostate · testicle · pancreatic ductal cell · trigeminal ganglion
BioGPS
More reference expression data
Chr.
Chromosome 2 (human) · Chromosome 1 (mouse)
Databases
NCBI: entry; OMA: entry

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TRPM8

Nodes99
Edges98
Triples160
Avg. degree1.98
Density0.020202
Components1

How this topic connects Entity context

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TRPM8

Top relations

Gene ontology · 25
TRPM8 → calcium channel activity, calcium ion transmembrane transport, calcium ion transport, cation transport, cellular calcium ion homeostasis, detection of temperature stimulus, endoplasmic reticulum, endoplasmic reticulum membrane, external side of plasma membrane, integral component of membrane, ion channel activity, ion transport, membrane, membrane raft, plasma membrane, protein binding, protein homodimerization activity, protein homotetramerization, protein homotrimerization, response to cold
Bgee · 15
TRPM8 → amniotic fluid, cerebellar cortex, endometrium, gonad, islet of Langerhans, left testis, pancreatic ductal cell, prostate, right lobe of liver, seminiferous tubule, spermatid, spermatocyte, spinal ganglia, testicle, trigeminal ganglion
RNA expression pattern · 15
TRPM8 → amniotic fluid, cerebellar cortex, endometrium, gonad, islet of Langerhans, left testis, pancreatic ductal cell, prostate, right lobe of liver, seminiferous tubule, spermatid, spermatocyte, spinal ganglia, testicle, trigeminal ganglion
related to Agonists · 14
TRPM8 → Ca2, Coolact, Cooling Agent, Experimentally, Frescolat MGA, Frescolat ML, HEK293, In, M8-Ag, Of, PMD, Traditionally, WS-12/Acoltremon, WS-23
related to Role in the nervous system · 12
TRPM8 → Application, Central, DRG, In, It, McKemy, The, This, TRP, TRPs, TRPV1, Using
related to Sensitization · 11
TRPM8 → Activation, An, L-menthol, Numerous, The, They, This, To, TRPM8-receptor, TRPM8-sensitization, Wasner
related to Antagonists · 7
TRPM8 → AcidCannabidivarinCannabigerolic, AMG-333RQ-00434739RQ-00203078PF-05105679, BCTC, M8 BAMTB5-benzyloxytryptamineAnandamideN-Arachidonoyl, M8-An, S1-S4, These
related to Desensitization · 7
TRPM8 → As, Ca2, Dessirier, Ethanol, Mutagenesis, Testing, The
related to Function · 7
TRPM8 → A-delta, Ca2, CPS-369, Na, The, The TRPM8, WS-12
related to Role in cancer · 7
TRPM8 → As, By, Ca2, ER, Immunofluorescence, LNCaP, This

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Important terminology

menthol cold receptor channel response agonists receptors protein prostate human bp gene also pain capsaicin cancer chr band stimuli sensitization

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
TRPM8AliasesTRPM8, LTRPC6, TRPP8, transient receptor potential cation channel subfamily M member 8, trp-p8, LTrpC-61.00infobox
TRPM8Band2q37.11.00infobox
TRPM8Band1|1 D1.00infobox
TRPM8Bgeeright lobe of liver1.00infobox
TRPM8Bgeeprostate1.00infobox
TRPM8Bgeetesticle1.00infobox
TRPM8Bgeepancreatic ductal cell1.00infobox
TRPM8Bgeetrigeminal ganglion1.00infobox
TRPM8Bgeeamniotic fluid1.00infobox
TRPM8Bgeeislet of Langerhans1.00infobox
TRPM8Bgeegonad1.00infobox
TRPM8Bgeeendometrium1.00infobox
TRPM8Bgeeleft testis1.00infobox
TRPM8Bgeeseminiferous tubule1.00infobox
TRPM8Bgeespinal ganglia1.00infobox
TRPM8Bgeespermatid1.00infobox
TRPM8Bgeecerebellar cortex1.00infobox
TRPM8Bgeespermatocyte1.00infobox
TRPM8BioGPSMore reference expression data1.00infobox
TRPM8Chr.Chromosome 2 (human)1.00infobox
TRPM8Chr.Chromosome 1 (mouse)1.00infobox
TRPM8DatabasesNCBI: entry; OMA: entry1.00infobox
TRPM8End234,019,522 bp1.00infobox
TRPM8End88,317,015 bp1.00infobox
TRPM8EnsemblENSG000001444811.00infobox
TRPM8Entrez790541.00infobox
TRPM8External IDsOMIM: 606678; MGI: 2181435; GeneCards: TRPM81.00infobox
TRPM8Gene location (Human)Gene location (Human)Chr.Chromosome 2 (human)Band2q37.1Start233,917,373 bpEnd234,019,522 bp1.00infobox
TRPM8Gene location (Mouse)Gene location (Mouse)Chr.Chromosome 1 (mouse)Band1|1 DStart88,205,383 bpEnd88,317,015 bp1.00infobox
TRPM8Gene ontologyprotein homodimerization activity1.00infobox

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