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Icilin

Icilin (AG-3-5) is a synthetic super-agonist of the transient receptor potential M8 (TRPM8) ion channel. Although structurally not related to menthol, it produces an extreme sensation of cold, both in humans and animals. It is almost 200 times more potent than menthol, and 2.5 times more efficacious. Despite their similar effects, icilin activates the…

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Icilin

Nodes10
Edges9
Triples1
Avg. degree1.8
Density0.2
Components1

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menthol trpm8 receptor ion although related despite ag-3-5 model references standard state synthetic pruritus ws-12 super-agonist transient potential m8 channel

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SubjectPredicateObjectConfidenceSrc
WS-12instance ofalthough despite its high potency it is less selective for TRPM8 over other related ion channels than are other compounds0.80text

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