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Pre-Bötzinger complex

The preBötzinger complex, often abbreviated as preBötC, is a functionally and anatomically specialized site in the ventral-lateral region of the lower medulla oblongata (i.e., lower brainstem). The preBötC is part of the ventral respiratory group of respiratory related interneurons. Its foremost function is to generate the inspiratory breathing rhythm in…

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Neuromodulation of preBötC rhythmicity

AgonistsAntagonistsGABAGlutamateSerotonin
28 related topics

Ionic currents

CurrentsAction potentialsBurstsSodiumMembrane potentials
17 related topics

Homeostatic changes in preBötC rhythmicity

Intermittent hypoxiaRett syndromeObstructive sleep apneaBotzinger complexCross-correlation
16 related topics

Neighboring respiratory sites and nuclei

SynapsesNeuronal networksRostralCaudalCerebellum
7 related topics

Key facts & relationships

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Location
brainstem
Function
generation of respiratory rhythm
NeuroLex ID
nlx_152600
System
Respiratory system

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Overview

Discovery

Functional definition of the preBötC

Anatomic definition of the preBötC

Eupnea and sigh

Neighboring respiratory sites and nuclei

Ionic currents

Neuromodulation of preBötC rhythmicity

Homeostatic changes in preBötC rhythmicity

Pathologies and the preBötC

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Map overview Semantic statistics

Pre-Bötzinger complex

Nodes97
Edges96
Triples87
Avg. degree1.98
Density0.020619
Components1

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Pre-Bötzinger complex

Top relations

related to Calcium-activated non-specific cation current (ICAN) · 24
Pre-Bötzinger complex → A-type, Although, AP, ATP, ATP-dependent, Bötzinger, Calcium-activated, Calcium-sensitive, CS, ICAN, L-type, Metabotropic, Moreover, N-type, NMDA, Other, P/Q-type, Studies, The, These
related to Eupnea and sigh · 20
Pre-Bötzinger complex → Additionally, BotC, Both, Bötzinger, Facial, Further, Gastrin-releasing, GRP, However, Hz, In, Neuromedin-B, NMB, P/Q, PMID, Producing, Robust, Sigh, The, VII
related to Homeostatic changes in preBötC rhythmicity · 19
Pre-Bötzinger complex → Acute, AIH, Blocking, Botzinger, BötC, Bötzinger, Exposure, GABA, GABAergic, Glycine, Glycinergic, However, Investigation, LTF, Rett, Synaptic, The, These, This
related to Neighboring respiratory sites and nuclei · 11
Pre-Bötzinger complex → Bötzinger, Efferent, From, In, Kölliker-Fuse, Located, Mononsynaptic, Other, RTN/pFRG, The, VRC
related to Oxygen sensing · 5
Pre-Bötzinger complex → Among, Bötzinger, Hypoxia, In, The
Function · 1
Pre-Bötzinger complex → generation of respiratory rhythm
Location · 1
Pre-Bötzinger complex → brainstem
NeuroLex ID · 1
Pre-Bötzinger complex → nlx_152600
System · 1
Pre-Bötzinger complex → Respiratory system

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Important terminology

prebötc neurons respiratory rhythm breathing activity inspiratory complex currents motor receptors also sodium bursts channels pre-bötzinger generation role receptor well

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Pre-Bötzinger complexFunctiongeneration of respiratory rhythm1.00infobox
Pre-Bötzinger complexLocationbrainstem1.00infobox
Pre-Bötzinger complexNeuroLex IDnlx_1526001.00infobox
Pre-Bötzinger complexSystemRespiratory system1.00infobox
apnea of prematurityinstance ofit has been used as a model to study pathological conditions0.80text
sudden infant death syndrome.The complex regulation of respiratory rhythm involves the integration of multiple signaling moleculesinstance ofit has been used as a model to study pathological conditions0.80text
the activation of numerous diverse metabotropicinstance ofit has been used as a model to study pathological conditions0.80text
ionotropic receptorsinstance ofit has been used as a model to study pathological conditions0.80text
Pre-Bötzinger complexrelated to Calcium-activated non-specific cation current (ICAN)Other0.60section
Pre-Bötzinger complexrelated to Calcium-activated non-specific cation current (ICAN)ICAN0.60section
Pre-Bötzinger complexrelated to Calcium-activated non-specific cation current (ICAN)When0.60section
Pre-Bötzinger complexrelated to Calcium-activated non-specific cation current (ICAN)Calcium-sensitive0.60section

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