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POT1: Pathology, Function & Interactions

Protection of telomeres protein 1 is a protein that in humans is encoded by the POT1 gene.

Language: English [EN]
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POT1 topic overview

The analysis highlights Pathology, Function and Interactions as prominent areas in the source structure around POT1.

Related topics
12
Source areas
4
Connected nodes
16
Extracted relationships
109
Concept neighborhoods
8
Bridge connections
16

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Pathology · 4 topics
Function · 3 topics
Interactions · 3 topics
Overview · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
POT1, CMM10, HGLM9, protection of telomeres 1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1XJV, 3KJO, 3KJP
Band
7q31.33 · 6|6 A3.1
Bgee
secondary oocyte · germinal epithelium · Achilles tendon · sperm · Epithelium of choroid plexus
BioGPS
More reference expression data
Chr.
Chromosome 7 (human) · Chromosome 6 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Interactions

Pathology

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How POT1 connects Entity context

The extracted context around POT1 shows recurring relationship patterns in the source. For example, POT1 → 8-hydroxy-2'-deoxyguanosine DNA binding, chromosome, DEAD/H-box RNA helicase binding, DNA binding, DNA duplex unwinding, establishment of protein localization to telomere, G-rich single-stranded DNA binding, G-rich strand telomeric DNA binding, negative regulation of telomerase activity, negative regulation of telomere maintenance via telomerase, nuclear telomere cap complex, nucleoplasm, nucleus, positive regulation of DNA helicase activity, positive regulation of DNA strand elongation, positive regulation of helicase activity, positive regulation of telomerase activity, positive regulation of telomere maintenance via telomerase, protein binding, regulation of DNA helicase activity Another extracted example is POT1 → Achilles tendon, cumulus cell, epiblast, Epithelium of choroid plexus, gastric mucosa, genital tubercle, germinal epithelium, gonad, Gonadal ridge, primitive streak, renal corpuscle, retinal pigment epithelium, secondary oocyte, sperm, tail of embryo, thymus, tibia, ventricular zone, zygote. Use these groups to spot repeated connection types before inspecting the individual relationships.

POT1

Top relations

Gene ontology · 33
POT1 → 8-hydroxy-2'-deoxyguanosine DNA binding, chromosome, DEAD/H-box RNA helicase binding, DNA binding, DNA duplex unwinding, establishment of protein localization to telomere, G-rich single-stranded DNA binding, G-rich strand telomeric DNA binding, negative regulation of telomerase activity, negative regulation of telomere maintenance via telomerase, nuclear telomere cap complex, nucleoplasm, nucleus, positive regulation of DNA helicase activity, positive regulation of DNA strand elongation, positive regulation of helicase activity, positive regulation of telomerase activity, positive regulation of telomere maintenance via telomerase, protein binding, regulation of DNA helicase activity
Bgee · 19
POT1 → Achilles tendon, cumulus cell, epiblast, Epithelium of choroid plexus, gastric mucosa, genital tubercle, germinal epithelium, gonad, Gonadal ridge, primitive streak, renal corpuscle, retinal pigment epithelium, secondary oocyte, sperm, tail of embryo, thymus, tibia, ventricular zone, zygote
RNA expression pattern · 19
POT1 → Achilles tendon, cumulus cell, epiblast, Epithelium of choroid plexus, gastric mucosa, genital tubercle, germinal epithelium, gonad, Gonadal ridge, primitive streak, renal corpuscle, retinal pigment epithelium, secondary oocyte, sperm, tail of embryo, thymus, tibia, ventricular zone, zygote
related to Function · 8
POT1 → Alternatively, DNA, In, Specifically, The, This, TIFs, TTAGGG
related to External links · 3
POT1 → Human Protection, PDB, PDBe-KB
Band · 2
POT1 → 6|6 A3.1, 7q31.33
Chr. · 2
POT1 → Chromosome 6 (mouse), Chromosome 7 (human)
End · 2
POT1 → 124,929,983 bp, 25,809,245 bp
related to Interactions · 2
POT1 → ACD, TINF2
related to Pathology · 2
POT1 → Increased, Mutations

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

gene human bp telomeres chromosome protein chr band telomere protection mouse location dna function external search 929 983 end 124

POT1 relationships Subject–Predicate–Object triples

TTTA extracted 109 structured relationships around POT1. Examples in this analysis include POT1 → Aliases → POT1, CMM10, HGLM9, protection of telomeres 1 and POT1 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1XJV, 3KJO, 3KJP. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
POT1AliasesPOT1, CMM10, HGLM9, protection of telomeres 11.00infobox
POT1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1XJV, 3KJO, 3KJP1.00infobox
POT1Band7q31.331.00infobox
POT1Band6|6 A3.11.00infobox
POT1Bgeesecondary oocyte1.00infobox
POT1Bgeegerminal epithelium1.00infobox
POT1BgeeAchilles tendon1.00infobox
POT1Bgeesperm1.00infobox
POT1BgeeEpithelium of choroid plexus1.00infobox
POT1Bgeegastric mucosa1.00infobox
POT1Bgeegonad1.00infobox
POT1Bgeetibia1.00infobox
POT1Bgeeventricular zone1.00infobox
POT1Bgeeretinal pigment epithelium1.00infobox
POT1Bgeegenital tubercle1.00infobox
POT1Bgeetail of embryo1.00infobox
POT1Bgeezygote1.00infobox
POT1Bgeecumulus cell1.00infobox
POT1BgeeGonadal ridge1.00infobox
POT1Bgeerenal corpuscle1.00infobox
POT1Bgeeprimitive streak1.00infobox
POT1Bgeeepiblast1.00infobox
POT1Bgeethymus1.00infobox
POT1BioGPSMore reference expression data1.00infobox
POT1Chr.Chromosome 7 (human)1.00infobox
POT1Chr.Chromosome 6 (mouse)1.00infobox
POT1DatabasesNCBI: entry; OMA: entry1.00infobox
POT1End124,929,983 bp1.00infobox
POT1End25,809,245 bp1.00infobox
POT1EnsemblENSG000001285131.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around POT1 bring nearby vocabulary together. In this analysis, examples include Telomeres, Protection and Human. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • POT1
    • Telomeres
    • Protection
    • Human
    • Dna
    • Telomere
    • Protein
    • Gene
    • Available
    • Damage
    • Elongation
    • Function
    • Pdb
  • pot1
    • Telomeres
    • Protection
    • Human
    • Dna
    • Telomere
    • Protein
    • Gene
    • Available
    • Damage
    • Elongation
    • Function
    • Pdb
  • protein
    • Telomeres
    • Activity
    • Complex
    • Member
    • Regulation
    • Shelterin
    • Telomerase
    • Telomere
    • Chromosome
    • Human
    • Maintenance
    • Nuclear
  • gene
    • Location
    • Bp
    • Chr
    • Chromosome
    • A3
    • End
    • Expression
    • Function
    • Human
    • Search
    • Mouse
    • Band
  • function
    • Search
    • Location
    • Maintenance
    • Nuclear
    • Bp
    • Chr
    • Chromosome
    • A3
    • Activity
    • Available
    • Complex
    • Elongation
  • telomerase
    • Regulation
    • Also
    • Shelterin
    • Telomere
    • Telomeres
  • shelterin
    • Telomere
    • Regulation
    • Telomerase
    • Telomeres
  • telomere
    • Damage
    • Response
    • Telomeres

Connections between topic areas Semantic bridges

For POT1, one of the stronger structural bridges in this analysis connects POT1 with Pathology. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
POT1Pathology · splits 12 ⟂ 5
POT1Function · splits 13 ⟂ 4
POT1Interactions · splits 13 ⟂ 4
POT1Overview · splits 14 ⟂ 3

Map overview Semantic statistics

POT1

Nodes17
Edges16
Triples109
Avg. degree1.88
Density0.117647
Components1

Source & methodology

TTTA analyzes the structure around POT1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Pathology, Function & Interactions, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — POT1 · EN edition · Analysis: TopicsToTalkAbout

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