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TBX4

T-box transcription factor Tbx4 is a transcription factor that belongs to T-box gene family that is involved in the regulation of embryonic developmental processes. The transcription factor is encoded by the TBX4 gene located on human chromosome 17. Tbx4 is known mostly for its role in the development of the hindlimb, but it also plays a critical role in…

Function, Clinical significance & Tissue distribution

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Aliases
TBX4, SPS, ICPPS, T-box 4, T-box transcription factor 4, PAPPAS
Band
17q23.2 · 11 C|11 51.42 cM
Bgee
right lung · upper lobe of left lung · Achilles tendon · cartilage tissue · tibial arteries
BioGPS
n/a
Chr.
Chromosome 17 (human) · Chromosome 11 (mouse)
Databases
NCBI: entry; OMA: entry

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Overview

Tissue distribution

Function

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Map overview Semantic statistics

TBX4

Nodes57
Edges56
Triples98
Avg. degree1.96
Density0.035088
Components1

How this topic connects Entity context

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TBX4

Top relations

Bgee · 19
TBX4 → abdominal wall, Achilles tendon, allantois, cartilage tissue, gallbladder, genital tubercle, human penis, left lung lobe, lower lobe of lung, placenta, primary oocyte, prostate, right lung, right lung lobe, secondary oocyte, tibial arteries, upper lobe of left lung, urinary bladder, zygote
RNA expression pattern · 19
TBX4 → abdominal wall, Achilles tendon, allantois, cartilage tissue, gallbladder, genital tubercle, human penis, left lung lobe, lower lobe of lung, placenta, primary oocyte, prostate, right lung, right lung lobe, secondary oocyte, tibial arteries, upper lobe of left lung, urinary bladder, zygote
Gene ontology · 14
TBX4 → angiogenesis, DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, embryonic limb morphogenesis, limb morphogenesis, lung development, morphogenesis of an epithelium, multicellular organism development, nucleus, regulation of transcription by RNA polymerase II, regulation of transcription, DNA-templated, skeletal system morphogenesis, transcription, DNA-templated
related to Function · 10
TBX4 → FGF, FGF-10, FGF-8, Fibroblast, Hox, In, T-box, Tbx5, These, Together
related to Clinical significance · 8
TBX4 → Disruption, Duplication, FGF-8/FGF-10, In, Mutations, Naiche, One, Tbx5
Band · 2
TBX4 → 11 C|11 51.42 cM, 17q23.2
Chr. · 2
TBX4 → Chromosome 11 (mouse), Chromosome 17 (human)
End · 2
TBX4 → 61,485,110 bp, 85,806,923 bp
related to Tissue distribution · 2
TBX4 → Along, Tbx5
Aliases · 1
TBX4 → TBX4, SPS, ICPPS, T-box 4, T-box transcription factor 4, PAPPAS

Important terminology Word statistics

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Important terminology

human factor gene bp limb development transcription chromosome 17 hindlimb expressed chr band tbx5 limbs mutations also t-box lung mouse

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
TBX4AliasesTBX4, SPS, ICPPS, T-box 4, T-box transcription factor 4, PAPPAS1.00infobox
TBX4Band17q23.21.00infobox
TBX4Band11 C|11 51.42 cM1.00infobox
TBX4Bgeeright lung1.00infobox
TBX4Bgeeupper lobe of left lung1.00infobox
TBX4BgeeAchilles tendon1.00infobox
TBX4Bgeecartilage tissue1.00infobox
TBX4Bgeetibial arteries1.00infobox
TBX4Bgeelower lobe of lung1.00infobox
TBX4Bgeeurinary bladder1.00infobox
TBX4Bgeeplacenta1.00infobox
TBX4Bgeeprostate1.00infobox
TBX4Bgeegallbladder1.00infobox
TBX4Bgeesecondary oocyte1.00infobox
TBX4Bgeezygote1.00infobox
TBX4Bgeeallantois1.00infobox
TBX4Bgeeleft lung lobe1.00infobox
TBX4Bgeeprimary oocyte1.00infobox
TBX4Bgeeright lung lobe1.00infobox
TBX4Bgeehuman penis1.00infobox
TBX4Bgeegenital tubercle1.00infobox
TBX4Bgeeabdominal wall1.00infobox
TBX4BioGPSn/a1.00infobox
TBX4Chr.Chromosome 17 (human)1.00infobox
TBX4Chr.Chromosome 11 (mouse)1.00infobox
TBX4DatabasesNCBI: entry; OMA: entry1.00infobox
TBX4End61,485,110 bp1.00infobox
TBX4End85,806,923 bp1.00infobox
TBX4EnsemblENSG000001210751.00infobox
TBX4Entrez94961.00infobox

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