Research any topic before you write.

Find related topics. | Discover entities. | See connections. | Build a topical map.

TBX4: Function, Clinical significance & Tissue distribution

T-box transcription factor Tbx4 is a transcription factor that belongs to T-box gene family that is involved in the regulation of embryonic developmental processes. The transcription factor is encoded by the TBX4 gene located on human chromosome 17. Tbx4 is known mostly for its role in the development of the hindlimb, but it also plays a critical role in…

Language: English [EN]
Use the mouse wheel or two fingers (on touchscreens) to zoom in and out of the map.
100%
More settings
100% 100% 100% 100% 100%

TBX4 topic overview

The analysis highlights Function, Clinical significance and Tissue distribution as prominent areas in the source structure around TBX4.

Related topics
52
Source areas
4
Connected nodes
56
Extracted relationships
98
Concept neighborhoods
27
Bridge connections
56

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 19 topics
Clinical significance · 16 topics
Overview · 9 topics
Tissue distribution · 8 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
TBX4, SPS, ICPPS, T-box 4, T-box transcription factor 4, PAPPAS
Band
17q23.2 · 11 C|11 51.42 cM
Bgee
right lung · upper lobe of left lung · Achilles tendon · cartilage tissue · tibial arteries
BioGPS
n/a
Chr.
Chromosome 17 (human) · Chromosome 11 (mouse)
Databases
NCBI: entry; OMA: entry

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Tissue distribution

Function

Clinical significance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How TBX4 connects Entity context

The extracted context around TBX4 shows recurring relationship patterns in the source. For example, TBX4 → abdominal wall, Achilles tendon, allantois, cartilage tissue, gallbladder, genital tubercle, human penis, left lung lobe, lower lobe of lung, placenta, primary oocyte, prostate, right lung, right lung lobe, secondary oocyte, tibial arteries, upper lobe of left lung, urinary bladder, zygote Another extracted example is TBX4 → angiogenesis, DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, embryonic limb morphogenesis, limb morphogenesis, lung development, morphogenesis of an epithelium, multicellular organism development, nucleus, regulation of transcription by RNA polymerase II, regulation of transcription, DNA-templated, skeletal system morphogenesis, transcription, DNA-templated. Use these groups to spot repeated connection types before inspecting the individual relationships.

TBX4

Top relations

Bgee · 19
TBX4 → abdominal wall, Achilles tendon, allantois, cartilage tissue, gallbladder, genital tubercle, human penis, left lung lobe, lower lobe of lung, placenta, primary oocyte, prostate, right lung, right lung lobe, secondary oocyte, tibial arteries, upper lobe of left lung, urinary bladder, zygote
RNA expression pattern · 19
TBX4 → abdominal wall, Achilles tendon, allantois, cartilage tissue, gallbladder, genital tubercle, human penis, left lung lobe, lower lobe of lung, placenta, primary oocyte, prostate, right lung, right lung lobe, secondary oocyte, tibial arteries, upper lobe of left lung, urinary bladder, zygote
Gene ontology · 14
TBX4 → angiogenesis, DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, embryonic limb morphogenesis, limb morphogenesis, lung development, morphogenesis of an epithelium, multicellular organism development, nucleus, regulation of transcription by RNA polymerase II, regulation of transcription, DNA-templated, skeletal system morphogenesis, transcription, DNA-templated
related to Function · 10
TBX4 → FGF, FGF-10, FGF-8, Fibroblast, Hox, In, T-box, Tbx5, These, Together
related to Clinical significance · 8
TBX4 → Disruption, Duplication, FGF-8/FGF-10, In, Mutations, Naiche, One, Tbx5
Band · 2
TBX4 → 11 C|11 51.42 cM, 17q23.2
Chr. · 2
TBX4 → Chromosome 11 (mouse), Chromosome 17 (human)
End · 2
TBX4 → 61,485,110 bp, 85,806,923 bp
related to Tissue distribution · 2
TBX4 → Along, Tbx5
Aliases · 1
TBX4 → TBX4, SPS, ICPPS, T-box 4, T-box transcription factor 4, PAPPAS

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

human factor gene bp limb development transcription chromosome 17 hindlimb expressed chr band tbx5 limbs mutations also t-box lung mouse

TBX4 relationships Subject–Predicate–Object triples

TTTA extracted 98 structured relationships around TBX4. Examples in this analysis include TBX4 → Aliases → TBX4, SPS, ICPPS, T-box 4, T-box transcription factor 4, PAPPAS and TBX4 → Band → 17q23.2. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
TBX4AliasesTBX4, SPS, ICPPS, T-box 4, T-box transcription factor 4, PAPPAS1.00infobox
TBX4Band17q23.21.00infobox
TBX4Band11 C|11 51.42 cM1.00infobox
TBX4Bgeeright lung1.00infobox
TBX4Bgeeupper lobe of left lung1.00infobox
TBX4BgeeAchilles tendon1.00infobox
TBX4Bgeecartilage tissue1.00infobox
TBX4Bgeetibial arteries1.00infobox
TBX4Bgeelower lobe of lung1.00infobox
TBX4Bgeeurinary bladder1.00infobox
TBX4Bgeeplacenta1.00infobox
TBX4Bgeeprostate1.00infobox
TBX4Bgeegallbladder1.00infobox
TBX4Bgeesecondary oocyte1.00infobox
TBX4Bgeezygote1.00infobox
TBX4Bgeeallantois1.00infobox
TBX4Bgeeleft lung lobe1.00infobox
TBX4Bgeeprimary oocyte1.00infobox
TBX4Bgeeright lung lobe1.00infobox
TBX4Bgeehuman penis1.00infobox
TBX4Bgeegenital tubercle1.00infobox
TBX4Bgeeabdominal wall1.00infobox
TBX4BioGPSn/a1.00infobox
TBX4Chr.Chromosome 17 (human)1.00infobox
TBX4Chr.Chromosome 11 (mouse)1.00infobox
TBX4DatabasesNCBI: entry; OMA: entry1.00infobox
TBX4End61,485,110 bp1.00infobox
TBX4End85,806,923 bp1.00infobox
TBX4EnsemblENSG000001210751.00infobox
TBX4Entrez94961.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around TBX4 bring nearby vocabulary together. In this analysis, examples include Mutations, Also and Expressed. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • TBX4
    • Mutations
    • Also
    • Expressed
    • Hindlimb
    • Tbx5
    • Transcription
    • Limbs
    • Development
    • Expression
    • Human
    • Limb
    • Formation
  • tbx4
    • Mutations
    • Also
    • Expressed
    • Hindlimb
    • Tbx5
    • Transcription
    • Limbs
    • Development
    • Expression
    • Human
    • Limb
    • Formation
  • transcription factor
    • Factor
    • Transcription
    • Gene
    • T-box
    • Chromosome
    • Function
    • Regulation
    • Tissue
    • Human
    • Embryonic
    • Location
    • Bp
  • embryonic developmental processes
    • Regulation
    • Allantois
    • Transcription
    • Gene
    • Development
    • Factor
    • Function
    • Proctodeum
    • Tissue
    • Developmental
    • Embryonic
    • Location
  • human chromosome 17
    • Chromosome
    • Human
    • Bp
    • Chr
    • Location
    • Gene
    • Band
    • Transcription
    • Function
    • Tissue
    • Factor
    • Mouse
  • fetal development
    • Expressed
    • Allantois
    • Embryonic
    • Formation
    • Lung
    • Also
    • Hindlimb
    • Transcription
    • Tbx4
    • Factor
    • Limb
    • Function
  • fibroblast growth factor
    • Transcription
    • Gene
    • T-box
    • Chromosome
    • Human
    • Function
    • Regulation
    • Tissue
    • Embryonic
    • Location
    • Tbx4
    • Bp
  • limb development
    • Signaling
    • Expressed
    • Allantois
    • Embryonic
    • Formation
    • Lung
    • Fgf-10
    • Fgf-8
    • Also
    • Hindlimb
    • Mouse
    • Role

Connections between topic areas Semantic bridges

For TBX4, one of the stronger structural bridges in this analysis connects TBX4 with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
TBX4Function · splits 37 ⟂ 20
TBX4Clinical significance · splits 40 ⟂ 17
TBX4Overview · splits 47 ⟂ 10
TBX4Tissue distribution · splits 48 ⟂ 9

Map overview Semantic statistics

TBX4

Nodes57
Edges56
Triples98
Avg. degree1.96
Density0.035088
Components1

Source & methodology

TTTA analyzes the structure around TBX4 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Clinical significance & Tissue distribution, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — TBX4 · EN edition · Analysis: TopicsToTalkAbout

For writers, content strategists, SEOs, marketers and creators — from quick topic research to advanced semantic analysis.