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Limb bud

The limb bud is a structure formed early in vertebrate limb development. As a result of interactions between the ectoderm and underlying mesoderm, formation occurs roughly around the fourth week of development. In the development of the human embryo the upper limb bud appears in the third week and the lower limb bud appears four days later.

Regions, Relationship between hox gene expression and limb patterning & Position and formation

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Relationship between hox gene expression and limb patterning

Hox genesChromosomeGastrulationPrimitive somitic mesodermDevelopment
19 related topics

Position and formation

Hox genesGene expressionT-box proteinsFGF10Proliferating
13 related topics

Overview

VertebrateLimb developmentEctodermMesodermThe development of the human embryo
21 related topics

Relevant genes and proteins

WNT3AGremlinBMPTranscription factors
4 related topics

Key facts & relationships

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Latin
gemmae membrorum
MeSH
D018878
Precursor
lateral plate mesoderm
TE
bud_by_E5.0.3.0.0.0.5 E5.0.3.0.0.0.5

Topics to explore

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Overview

Position and formation

Relationship between hox gene expression and limb patterning

Relevant experiments

Relevant genes and proteins

Advanced semantic analysis

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Map overview Semantic statistics

Limb bud

Nodes64
Edges63
Triples104
Avg. degree1.97
Density0.03125
Components1

How this topic connects Entity context

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Limb bud

Top relations

related to Relevant genes and proteins · 41
Limb bud → Activated, Acts, AER, AER's, Also, Associated, BMP, By, Creates, Determines, Digit, FGF, FGF10, FGF8, Gremlin, Hox, HoxC10, HoxC11, Influences, Initially
related to Relationship between hox gene expression and limb patterning · 23
Limb bud → Additional, Although, Chicken, FGF, Hox, Hoxa, Hoxb, Hoxc, HOXC10, HOXC11, HOXC4, HOXC5, HOXC6, HOXC8, HOXC9, Hoxd, RA, Shh, The, The Hox
related to Relevant experiments · 18
Limb bud → AER, By, FGF10, FGF10-containing, HOXC10, Knocking, Other, Pitx1, Placement, T-box, Tbx, Tbx4, Tbx5, The Hox, This, When, When Pitx1, ZPA
related to Position and formation · 17
Limb bud → AER, All, Before, FGF, FGF10, FGF8, Hox, In, T-box, The FGF8, The Hox, This FGF10, Though, Wnt, WNT2B, WNT3, WNT8C
Latin · 1
Limb bud → gemmae membrorum
MeSH · 1
Limb bud → D018878
Precursor · 1
Limb bud → lateral plate mesoderm
TE · 1
Limb bud → bud_by_E5.0.3.0.0.0.5 E5.0.3.0.0.0.5
is a · 1
Limb bud → structure formed early in vertebrate limb development

Important terminology Word statistics

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Important terminology

limb development bud expression signaling aer cells zpa hox shh mesoderm tbx4 formation fgf10 signals pitx1 hindlimb developing fgf8 mesenchyme

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Limb budLatingemmae membrorum1.00infobox
Limb budMeSHD0188781.00infobox
Limb budPrecursorlateral plate mesoderm1.00infobox
Limb budTEbud_by_E5.0.3.0.0.0.5 E5.0.3.0.0.0.51.00infobox
Limb budis astructure formed early in vertebrate limb development0.90text
Limb budrelated to Position and formationThe Hox0.60section
Limb budrelated to Position and formationThough0.60section
Limb budrelated to Position and formationHox0.60section
Limb budrelated to Position and formationAll0.60section
Limb budrelated to Position and formationT-box0.60section
Limb budrelated to Position and formationIn0.60section
Limb budrelated to Position and formationWnt0.60section

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