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Apical ectodermal ridge

The apical ectodermal ridge (AER) is a structure that forms from the ectodermal cells at the distal end of each limb bud and acts as a major signaling center to ensure proper development of a limb. After the limb bud induces AER formation, the AER and limb mesenchyme—including the zone of polarizing activity (ZPA)—continue to communicate with each other…

Function, Overview & Transplantation experiments

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Key facts & relationships

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Latin
crista ectodermalis apicalis
TE
ectodermal ridge_by_E5.0.3.0.0.3.4 E5.0.3.0.0.3.4

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Overview

Structure

Associated molecules

Function

Transplantation experiments

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Map overview Semantic statistics

Apical ectodermal ridge

Nodes68
Edges67
Triples36
Avg. degree1.97
Density0.029412
Components1

How this topic connects Entity context

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Apical ectodermal ridge

Top relations

related to Associated molecules · 29
Apical ectodermal ridge → Activated, Acts, AER, AER’s, Also, Associated, BMP, By, Creates, Determines, Digit, FGF, FGF10, FGF8, Gremlin, Hox, Influences, Initially, Later, Pitx1
related to External links · 5
Apical ectodermal ridge → Archived, Ectodermal Ridge, June, Musculoskeletal- Limb Development- Apical, UNSW Embryology
Latin · 1
Apical ectodermal ridge → crista ectodermalis apicalis
TE · 1
Apical ectodermal ridge → ectodermal ridge_by_E5.0.3.0.0.3.4 E5.0.3.0.0.3.4

Important terminology Word statistics

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Important terminology

aer limb bud expression mesenchyme shh mesoderm fgf10 development fgf8 zpa cells ectodermal hox anterior-posterior formation zone fgfs transplantation distal

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Apical ectodermal ridgeLatincrista ectodermalis apicalis1.00infobox
Apical ectodermal ridgeTEectodermal ridge_by_E5.0.3.0.0.3.4 E5.0.3.0.0.3.41.00infobox
Apical ectodermal ridgerelated to Associated moleculesAssociated0.60section
Apical ectodermal ridgerelated to Associated moleculesFGF100.60section
Apical ectodermal ridgerelated to Associated moleculesInitially0.60section
Apical ectodermal ridgerelated to Associated moleculesTbx0.60section
Apical ectodermal ridgerelated to Associated moleculesLater0.60section
Apical ectodermal ridgerelated to Associated moleculesWNT8C0.60section
Apical ectodermal ridgerelated to Associated moleculesWNT2B0.60section
Apical ectodermal ridgerelated to Associated moleculesWNT3A0.60section
Apical ectodermal ridgerelated to Associated moleculesAER0.60section
Apical ectodermal ridgerelated to Associated moleculesFGF80.60section

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