Research any topic before you write.

Find related topics. | Discover entities. | See connections. | Build a topical map.

TBX5 (gene)

T-box transcription factor TBX5, (T-box protein 5) is a protein that in humans is encoded by the TBX5 gene. Abnormalities in the TBX5 gene can result in altered limb development, Holt-Oram syndrome, Tetra-amelia syndrome, and cardiac and skeletal problems.

Function, Interactions & Clinical significance

Use the mouse wheel or two fingers (on touchscreens) to zoom in and out of the map.

Research this topic

Explore the main themes, entities and connections around TBX5 (gene). Start with the topic map, then use the sections below for research and deeper semantic analysis.

Explore this topic

Start with a few of the strongest sections from the source topic. These are research directions, not a list of keywords you must use.

Function

11 related topics

Interactions

3 related topics

Clinical significance

1 related topics

Overview

9 related topics

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
TBX5, HOS, T-box 5, T-box transcription factor 5
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2X6U, 2X6V, 4S0H, 5BQD
Band
12q24.21 · 5 F|5 60.42 cM
Bgee
tendon of biceps brachii · cardiac muscle tissue of right atrium · buccal mucosa cell · right auricle of heart · lower lobe of lung
BioGPS
More reference expression data
Chr.
Chromosome 12 (human) · Chromosome 5 (mouse)

Topics to explore

Browse the full topic structure. Each item opens a new analysis centered on that subject.

Overview

Function

Clinical significance

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

Map overview Semantic statistics

TBX5 (gene)

Nodes29
Edges28
Triples118
Avg. degree1.93
Density0.068966
Components1

How this topic connects Entity context

See the strongest relationship patterns around the current topic before diving into the raw triples.

TBX5 (gene)

Top relations

Gene ontology · 46
TBX5 (gene) → atrial septum development, atrial septum morphogenesis, atrioventricular valve morphogenesis, bundle of His development, cardiac left ventricle formation, cardiac muscle cell differentiation, cell migration involved in coronary vasculogenesis, cell-cell signaling, cytoplasm, development of the heart, DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, embryonic forelimb morphogenesis, embryonic limb morphogenesis, endocardial cushion development, forelimb morphogenesis, lung development, morphogenesis of an epithelium
Bgee · 20
TBX5 (gene) → buccal mucosa cell, Cardiac muscle tissue of myocardium, cardiac muscle tissue of right atrium, genital tubercle, human penis, inferior vena cava, interatrial septum, lower lobe of lung, myocardium of left ventricle, oocyte, primordial ventricle, right auricle of heart, right lung, right ventricle, sinus venosus, superior vena cava, tendon of biceps brachii, urethra, vena cava, visceral pleura
RNA expression pattern · 20
TBX5 (gene) → buccal mucosa cell, Cardiac muscle tissue of myocardium, cardiac muscle tissue of right atrium, genital tubercle, human penis, inferior vena cava, interatrial septum, lower lobe of lung, myocardium of left ventricle, oocyte, primordial ventricle, right auricle of heart, right lung, right ventricle, sinus venosus, superior vena cava, tendon of biceps brachii, urethra, vena cava, visceral pleura
Band · 2
TBX5 (gene) → 12q24.21, 5 F|5 60.42 cM
Chr. · 2
TBX5 (gene) → Chromosome 12 (human), Chromosome 5 (mouse)
End · 2
TBX5 (gene) → 114,408,442 bp, 120,023,284 bp
related to Interactions · 2
TBX5 (gene) → GATA4, TBX5
Aliases · 1
TBX5 (gene) → TBX5, HOS, T-box 5, T-box transcription factor 5
Available structures · 1
TBX5 (gene) → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2X6U, 2X6V, 4S0H, 5BQD
BioGPS · 1
TBX5 (gene) → More reference expression data

Important terminology Word statistics

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

tbx5 gene development t-box human transcription protein factor heart syndrome chromosome 12 forelimb bp limb involved cardiac chr band genes

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
TBX5 (gene)AliasesTBX5, HOS, T-box 5, T-box transcription factor 51.00infobox
TBX5 (gene)Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2X6U, 2X6V, 4S0H, 5BQD1.00infobox
TBX5 (gene)Band12q24.211.00infobox
TBX5 (gene)Band5 F|5 60.42 cM1.00infobox
TBX5 (gene)Bgeetendon of biceps brachii1.00infobox
TBX5 (gene)Bgeecardiac muscle tissue of right atrium1.00infobox
TBX5 (gene)Bgeebuccal mucosa cell1.00infobox
TBX5 (gene)Bgeeright auricle of heart1.00infobox
TBX5 (gene)Bgeelower lobe of lung1.00infobox
TBX5 (gene)Bgeeright ventricle1.00infobox
TBX5 (gene)Bgeemyocardium of left ventricle1.00infobox
TBX5 (gene)Bgeevisceral pleura1.00infobox
TBX5 (gene)Bgeeright lung1.00infobox
TBX5 (gene)Bgeeoocyte1.00infobox
TBX5 (gene)BgeeCardiac muscle tissue of myocardium1.00infobox
TBX5 (gene)Bgeevena cava1.00infobox
TBX5 (gene)Bgeesinus venosus1.00infobox
TBX5 (gene)Bgeegenital tubercle1.00infobox
TBX5 (gene)Bgeeprimordial ventricle1.00infobox
TBX5 (gene)Bgeehuman penis1.00infobox
TBX5 (gene)Bgeeinferior vena cava1.00infobox
TBX5 (gene)Bgeeurethra1.00infobox
TBX5 (gene)Bgeesuperior vena cava1.00infobox
TBX5 (gene)Bgeeinteratrial septum1.00infobox
TBX5 (gene)BioGPSMore reference expression data1.00infobox
TBX5 (gene)Chr.Chromosome 12 (human)1.00infobox
TBX5 (gene)Chr.Chromosome 5 (mouse)1.00infobox
TBX5 (gene)DatabasesNCBI: entry; OMA: entry1.00infobox
TBX5 (gene)End114,408,442 bp1.00infobox
TBX5 (gene)End120,023,284 bp1.00infobox

Related concept clusters Concept neighborhoods

These clusters group vocabulary that occurs around closely connected concepts in the source material.

    Connections between topic areas Semantic bridges

    Bridges can reveal useful research angles that are easy to miss in a flat list of related terms.

    Min side: 3
    For writers, content strategists, SEOs, marketers and creators — from quick topic research to advanced semantic analysis.