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T790M

T790M, also known as Thr790Met, is a gatekeeper mutation of the epidermal growth factor receptor (EGFR). The mutation substitutes a threonine (T) with a methionine (M) at position 790 of exon 20, affecting the ATP binding pocket of the EGFR kinase domain. Threonine is a small polar amino acid; methionine is a larger nonpolar amino acid. Rather than…

Clinical & Overview

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Clinical

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T790M

Nodes16
Edges15
Triples11
Avg. degree1.88
Density0.125
Components1

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T790M

Top relations

related to Clinical · 10
T790M → ATP, EGFR, EGFR TKI, FDA-approved, In November, NSCLC, Over, Tagrisso, TKI, US FDA

Important terminology Word statistics

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Important terminology

egfr mutation threonine methionine atp binding osimertinib polar epidermal growth factor receptor pocket kinase domain small nonpolar inhibitors resistance exon

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
osimertinib can overcome this resistanceinstance ofirreversible covalent inhibitors0.80text
T790Mrelated to ClinicalOver0.60section
T790Mrelated to ClinicalEGFR0.60section
T790Mrelated to ClinicalTKI0.60section
T790Mrelated to ClinicalATP0.60section
T790Mrelated to ClinicalIn November0.60section
T790Mrelated to ClinicalUS FDA0.60section
T790Mrelated to ClinicalTagrisso0.60section
T790Mrelated to ClinicalNSCLC0.60section
T790Mrelated to ClinicalFDA-approved0.60section
T790Mrelated to ClinicalEGFR TKI0.60section

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