SARM1

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Relevance to human disease

Traumatic brain injury Neuropathy Diabetic neuropathy Schwann cell Charcot-Marie-Tooth

32 related topics

Regulation of enzymatic activity

NAD+NADP Pyridines Nicotinamide Orthosteric

10 related topics

Function

Toll-like receptor Adaptor protein Nervous system Macrophages T cells

9 related topics

Overview

Enzyme Gene Evolutionarily conserved Toll/Interleukin receptor-1 NADase

12 related topics

Key facts & relationships

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3.2.2.6: ↗
Aliases: SARM1, MyD88-5, SAMD2, SARM, sterile alpha and TIR motif containing 1, hHsTIR
Band: 17q11.2 · 11 B5|11 46.74 cM
Bgee: body of pancreas · islet of Langerhans · ganglionic eminence · ventricular zone · anterior pituitary
BioGPS: n/a
Chr.: Chromosome 17 (human) · Chromosome 11 (mouse)

Topics to explore

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Overview

Enzyme
Gene
Evolutionarily conserved Conserved sequence
Toll/Interleukin receptor-1 Toll-Interleukin receptor
NADase NAD+ glycohydrolase
Archaea
Nematode worms Caenorhabditis elegans
Fruit flies Drosophila
Expressed Gene expression
Neurons Neuron
Axons Axon
Mitochondria Mitochondrion

Function

Toll-like receptor
Adaptor protein Signal transducing adaptor protein
Nervous system
Macrophages Macrophage
T cells T cell
CADPR Cyclic ADP-ribose
NAADP Nicotinic acid adenine dinucleotide phosphate
Ca2+-signaling Calcium signaling
CD38

Regulation of enzymatic activity

NAD+ Nicotinamide adenine dinucleotide
NADP Nicotinamide adenine dinucleotide phosphate
Pyridines Pyridine
Nicotinamide
Orthosteric Orthosteric site
NMN Nicotinamide mononucleotide
Neurotoxins Neurotoxin
Vacor
NAMPT Nicotinamide phosphoribosyltransferase
MAP kinase Mitogen-activated protein kinase

Relevance to human disease

Traumatic brain injury
Neuropathy Peripheral neuropathy
Diabetic neuropathy
Schwann cell
Charcot-Marie-Tooth Charcot–Marie–Tooth disease
Hereditary spastic paraplegia
NMNAT2
Fetal akinesia deformation sequence
Polyneuropathy
Erythromelalgia
Amyotrophic lateral sclerosis
WldS mutation Wallerian degeneration
Drosophila melanogaster
Mutagenesis Mutagenesis (molecular biology technique)
Knockout Knockout mouse
IPSC Induced pluripotent stem cell
N-terminus
Armadillo (ARM) Armadillo repeat
HEAT HEAT repeat
Sterile alpha motif
C-terminal
Transferase
ATP Adenosine triphosphate
Allosteric Allosteric regulation
TIR domain Interleukin-1 receptor family
Adenosine diphosphate ribose
Phosphatidylserine
Membrane permeability
Peripheral nervous system
Central nervous system

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Map overview Semantic statistics

Nodes68

Edges67

Triples127

Avg. degree1.97

Density0.029412

Components1

How this topic connects Entity context

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SARM1

Top relations

Gene ontology · 25

SARM1 → axon, cell differentiation, cell junction, cell projection, cytoplasm, cytosol, dendrite, extrinsic component of mitochondrial outer membrane, immune system process, innate immune response, microtubule, microtubule cytoskeleton, mitochondrion, negative regulation of MyD88-independent toll-like receptor signaling pathway, nervous system development, positive regulation of signal transduction, protein binding, regulation of apoptotic process, regulation of dendrite morphogenesis, regulation of neuron death

Bgee · 19

SARM1 → anterior pituitary, body of pancreas, body of uterus, dentate gyrus of hippocampal formation granule cell, ganglionic eminence, granulocyte, islet of Langerhans, neural layer of retina, neural tube, primary visual cortex, right adrenal gland, right uterine tube, spinal ganglia, stellate ganglion, stromal cell of endometrium, superior cervical ganglion, thoracic ganglia, ventricular zone, visual cortex

RNA expression pattern · 19

related to Wallerian degeneration pathway · 17

SARM1 → ARM, ARM-ARM, ARM-SAM, ARM-TIR, C-terminal Toll/Interleukin-1, Drosophila, HEAT, In, Loss, N-terminus, SAM, SARM1's, The, The SARM1, TIR, Wallerian, WldS

related to Regulation of enzymatic activity · 8

SARM1 → For NAD, NAADP, NAD, NADP, Non-endogenous, SARM1's, SARM1's TIR, TIR

related to Function · 7

SARM1 → Because SARM1, By, Ca2, CD38, NAADP, Toll-like, While SARM1

related to Relevance to human disease · 4

SARM1 → Charcot-Marie-Tooth, Loss-of-function, Possible, Schwann

Band · 2

SARM1 → 11 B5|11 46.74 cM, 17q11.2

Chr. · 2

SARM1 → Chromosome 11 (mouse), Chromosome 17 (human)

End · 2

SARM1 → 28,404,049 bp, 78,388,580 bp

Important terminology Word statistics

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

activity sarm1's nad human tir nmnat2 nmn enzymatic domain gene allosteric bp axon degeneration pathway enzyme protein chr band region

Entity relationships Subject–Predicate–Object triples

Subject	Predicate	Object	Confidence	Src
SARM1	3.2.2.6	↗	1.00	infobox
SARM1	Aliases	SARM1, MyD88-5, SAMD2, SARM, sterile alpha and TIR motif containing 1, hHsTIR	1.00	infobox
SARM1	Band	17q11.2	1.00	infobox
SARM1	Band	11 B5\|11 46.74 cM	1.00	infobox
SARM1	Bgee	body of pancreas	1.00	infobox
SARM1	Bgee	islet of Langerhans	1.00	infobox
SARM1	Bgee	ganglionic eminence	1.00	infobox
SARM1	Bgee	ventricular zone	1.00	infobox
SARM1	Bgee	anterior pituitary	1.00	infobox
SARM1	Bgee	granulocyte	1.00	infobox
SARM1	Bgee	right uterine tube	1.00	infobox
SARM1	Bgee	stromal cell of endometrium	1.00	infobox
SARM1	Bgee	right adrenal gland	1.00	infobox
SARM1	Bgee	body of uterus	1.00	infobox
SARM1	Bgee	superior cervical ganglion	1.00	infobox
SARM1	Bgee	neural layer of retina	1.00	infobox
SARM1	Bgee	stellate ganglion	1.00	infobox
SARM1	Bgee	dentate gyrus of hippocampal formation granule cell	1.00	infobox
SARM1	Bgee	spinal ganglia	1.00	infobox
SARM1	Bgee	thoracic ganglia	1.00	infobox
SARM1	Bgee	neural tube	1.00	infobox
SARM1	Bgee	visual cortex	1.00	infobox
SARM1	Bgee	primary visual cortex	1.00	infobox
SARM1	BioGPS	n/a	1.00	infobox
SARM1	Chr.	Chromosome 17 (human)	1.00	infobox
SARM1	Chr.	Chromosome 11 (mouse)	1.00	infobox
SARM1	Databases	NCBI: entry; OMA: entry	1.00	infobox
SARM1	End	28,404,049 bp	1.00	infobox
SARM1	End	78,388,580 bp	1.00	infobox
SARM1	Ensembl	ENSG00000004139	1.00	infobox

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