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Piwi-interacting RNA

Piwi-interacting RNA (piRNA) is the largest class of small non-coding RNA molecules expressed in animal cells. piRNAs form RNA-protein complexes through interactions with piwi-subfamily Argonaute proteins. These piRNA complexes are mostly involved in the epigenetic and post-transcriptional silencing of transposable elements and other spurious or…

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Function

Small RNAs Gene silencing Transposons Antisense Embryo

18 related topics

Characteristics

Vertebrates Invertebrates Biogenesis Secondary structure Nucleotides

13 related topics

History and loci

Genome Gypsy Germlines Retrotransposons P-element

11 related topics

Biogenesis

DNA Pachytene Transcribed Cleavage Adenine

12 related topics

Topics to explore

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Overview

Non-coding Non-coding RNA
RNA
Protein
Piwi
Argonaute
Epigenetic Epigenetics
Post-transcriptional Post-transcriptional modification
Transposable elements Transposable element
Germ line
Adaptive immunity
MicroRNA
Dicer
MiRNA
SiRNA

Characteristics

History and loci

Genome
Gypsy LTR retrotransposon
Germlines Germline
Retrotransposons Retrotransposon
P-element
Bioinformatics
Genes
Testes
Ovaries
Nucleus Cell nucleus
Cytoplasm

Classification

Eukaryotes Eukaryote
Schizosaccharomyces pombe

Biogenesis

DNA
Pachytene
Transcribed Transcription (genetics)
Cleavage Bond cleavage
Adenine
Species
Conserved Conserved sequence
Biosynthetic
Mechanism Mechanism (biology)
Tudor protein
Vasa Vasa gene
Phased small interfering RNAs (phasiRNAs) Phased small interfering RNA

Function

Accessory proteins of the piRNA pathway

Tudor domains Tudor domain

Investigation

Next-generation sequencing
Illumina Illumina (company)
PCR Polymerase chain reaction

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Piwi-interacting RNA

Nodes83

Edges82

Triples24

Avg. degree1.98

Density0.024096

Components1

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Piwi-interacting RNA

Top relations

related to history · 14

Piwi-interacting RNA → Any, Aravin, Drosophila, Gypsies, Gypsy, In, Indeed, P-element, Piwi, Repression, RNA-mediated, Sequencing, The, This

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Important terminology

pirna pirnas piwi proteins rna drosophila aub ago3 transposon silencing species transposons mechanism biogenesis pathway identified ping-pong proposed small melanogaster

Entity relationships Subject–Predicate–Object triples

Subject	Predicate	Object	Confidence	Src
sponges	instance of	Ping-pong signatures have been identified in very primitive animals	0.80	text
cnidarians	instance of	Ping-pong signatures have been identified in very primitive animals	0.80	text
pointing to the existence of the ping-pong cycle already in the early branches of metazoans.Ping PongThe piRNA Ping-Pong pathway was first proposed from studies in Drosophila where the piRNA associated with the two cytoplasmic Piwi proteins	instance of	Ping-pong signatures have been identified in very primitive animals	0.80	text
Aubergine	instance of	Ping-pong signatures have been identified in very primitive animals	0.80	text
Kumo/Qin	instance of	and Ago3.It is likely that the mechanism of Ping-Pong is primarily coordinated by Krimper but factors	0.80	text
Vasa	instance of	and Ago3.It is likely that the mechanism of Ping-Pong is primarily coordinated by Krimper but factors	0.80	text
in addition to other factors have necessary functions in the Ping-Pong mechanism.Phased piRNA biogenesisIn the Drosophila germline	instance of	and Ago3.It is likely that the mechanism of Ping-Pong is primarily coordinated by Krimper but factors	0.80	text
the cytoplasmic PIWI proteins Aubergine	instance of	and Ago3.It is likely that the mechanism of Ping-Pong is primarily coordinated by Krimper but factors	0.80	text
in addition to other factors have necessary functions in the Ping-Pong mechanism	instance of	and Ago3.It is likely that the mechanism of Ping-Pong is primarily coordinated by Krimper but factors	0.80	text
Piwi4	instance of	in mosquitoes the PIWI family of proteins has expanded and some PIWI proteins have been identified as antiviral	0.80	text
Piwi-interacting RNA	related to history	In	0.60	section
Piwi-interacting RNA	related to history	Gypsy	0.60	section

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