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Plexin: Structure, Function & Overview

A plexin is a protein which acts as a receptor for semaphorin family signaling proteins. It is classically known for its expression on the surface of axon growth cones and involvement in signal transduction to steer axon growth away from the source of semaphorin. Plexin also has implications in development of other body systems by activating GTPase…

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Plexin topic overview

The analysis highlights Structure, Function and Overview as prominent areas in the source structure around Plexin.

Related topics
79
Source areas
3
Connected nodes
82
Extracted relationships
49
Concept neighborhoods
24
Bridge connections
82

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Structure · 36 topics
Function · 35 topics
Overview · 8 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

AlphaFold
IPR031148 · PF08337
Available protein structures:
IPR031148 · PF08337
InterPro
IPR031148
Membranome
17
PDB
IPR031148 PF08337 (ECOD; PDBsum)
Pfam
PF08337

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure

Function

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Plexin connects Entity context

The extracted context around Plexin shows recurring relationship patterns in the source. For example, Plexin → Class, Nine, PLXNA1, PLXNA2, PLXNA3, PLXNA4AClass, PLXNB1, PLXNB2, PLXNB3Class, PLXNC1Class, PLXND1, These Another extracted example is Plexin → GAP, GTPase-Activating Protein, Highly, In, Rap, RBD, Rho-GTPase, Rho-GTPases, Rnd-family Rho-GTPases, These GTPases, When. Use these groups to spot repeated connection types before inspecting the individual relationships.

Plexin

Top relations

related to Classes · 12
Plexin → Class, Nine, PLXNA1, PLXNA2, PLXNA3, PLXNA4AClass, PLXNB1, PLXNB2, PLXNB3Class, PLXNC1Class, PLXND1, These
related to Intracellular · 11
Plexin → GAP, GTPase-Activating Protein, Highly, In, Rap, RBD, Rho-GTPase, Rho-GTPases, Rnd-family Rho-GTPases, These GTPases, When
related to Extracellular · 9
Plexin → All, Before, Collectively, Each, IPT, N-terminus, PSI, SEMA, This
related to Function · 4
Plexin → Each, Genetic, Malfunction, Plexins
AlphaFold · 2
Plexin → IPR031148, PF08337
Available protein structures: · 2
Plexin → IPR031148, PF08337
is a · 2
Plexin → only known receptor molecule to have a GAP domain, protein which acts as a receptor for semaphorin family signaling proteins
related to Role in intelligence · 2
Plexin → In, IQ
InterPro · 1
Plexin → IPR031148
Membranome · 1
Plexin → 17

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

semaphorin development plexins growth extracellular intracellular binding signaling plxnd1 axon domains cones well proteins structure domain protein activation cell effects

Plexin relationships Subject–Predicate–Object triples

TTTA extracted 49 structured relationships around Plexin. Examples in this analysis include Plexin → AlphaFold → IPR031148 and Plexin → AlphaFold → PF08337. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
PlexinAlphaFoldIPR0311481.00infobox
PlexinAlphaFoldPF083371.00infobox
PlexinAvailable protein structures:IPR0311481.00infobox
PlexinAvailable protein structures:PF083371.00infobox
PlexinInterProIPR0311481.00infobox
PlexinMembranome171.00infobox
PlexinPDBIPR031148 PF08337 (ECOD; PDBsum)1.00infobox
PlexinPfamPF083371.00infobox
PlexinSymbolPLXN1.00infobox
Plexinis aprotein which acts as a receptor for semaphorin family signaling proteins0.90text
Plexinis aonly known receptor molecule to have a GAP domain0.90text
Plexinrelated to ClassesNine0.60section

Related concept clusters Concept neighborhoods

The concept neighborhoods around Plexin bring nearby vocabulary together. In this analysis, examples include Semaphorin, Domains and Intracellular. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Plexin
    • Semaphorin
    • Domains
    • Intracellular
    • Growth
    • Activation
    • Cones
    • Well
    • Signaling
    • Actin
    • Clathrin-mediated
    • Destabilization
    • Endocytosis
  • plexin
    • Semaphorin
    • Domains
    • Intracellular
    • Growth
    • Activation
    • Cones
    • Well
    • Signaling
    • Actin
    • Clathrin-mediated
    • Destabilization
    • Endocytosis
  • semaphorin
    • Binding
    • Dimers
    • Domains
    • Signaling
    • Plexins
    • Class
    • Receptors
    • Activation
    • Axon
    • Cones
    • Intracellular
    • Growth
  • axon
    • Kidney
    • Receptors
    • Growth
    • Cones
    • Development
    • Actin
    • Clathrin-mediated
    • Destabilization
    • Domain
    • Endocytosis
    • Microtubule
    • Plexin
  • growth cones
    • Growth
    • Actin
    • Clathrin-mediated
    • Destabilization
    • Endocytosis
    • Microtubule
    • Polymer
    • Resulting
    • Results
    • Activation
    • Well
    • Plexin
  • actin
    • Clathrin-mediated
    • Destabilization
    • Endocytosis
    • Microtubule
    • Polymer
    • Resulting
    • Results
    • Activation
    • Cones
    • Well
    • Growth
    • Receptors
  • development
    • Effects
    • Kidney
    • Plxna2
    • Intracellular
    • Plexins
    • Plexin
    • Enzymes
    • Domain
    • Plxna1
    • Protein
    • Receptors
    • Extracellular
  • intracellular
    • Domains
    • Dimers
    • Gap
    • Protein
    • Plexin
    • Extracellular
    • Binding
    • Semaphorin
    • Domain
    • Effects
    • Kidney
    • Activation

Connections between topic areas Semantic bridges

For Plexin, one of the stronger structural bridges in this analysis connects Plexin with Structure. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
PlexinStructure · splits 46 ⟂ 37
PlexinFunction · splits 47 ⟂ 36
PlexinOverview · splits 74 ⟂ 9

Map overview Semantic statistics

Plexin

Nodes83
Edges82
Triples49
Avg. degree1.98
Density0.024096
Components1

Source & methodology

TTTA analyzes the structure around Plexin to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Structure, Function & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Plexin · EN edition · Analysis: TopicsToTalkAbout

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