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Plexin

A plexin is a protein which acts as a receptor for semaphorin family signaling proteins. It is classically known for its expression on the surface of axon growth cones and involvement in signal transduction to steer axon growth away from the source of semaphorin. Plexin also has implications in development of other body systems by activating GTPase…

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Key facts & relationships

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AlphaFold
IPR031148 · PF08337
Available protein structures:
IPR031148 · PF08337
InterPro
IPR031148
Membranome
17
PDB
IPR031148 PF08337 (ECOD; PDBsum)
Pfam
PF08337

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Map overview Semantic statistics

Plexin

Nodes83
Edges82
Triples49
Avg. degree1.98
Density0.024096
Components1

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Plexin

Top relations

related to Classes · 12
Plexin → Class, Nine, PLXNA1, PLXNA2, PLXNA3, PLXNA4AClass, PLXNB1, PLXNB2, PLXNB3Class, PLXNC1Class, PLXND1, These
related to Intracellular · 11
Plexin → GAP, GTPase-Activating Protein, Highly, In, Rap, RBD, Rho-GTPase, Rho-GTPases, Rnd-family Rho-GTPases, These GTPases, When
related to Extracellular · 9
Plexin → All, Before, Collectively, Each, IPT, N-terminus, PSI, SEMA, This
related to Function · 4
Plexin → Each, Genetic, Malfunction, Plexins
AlphaFold · 2
Plexin → IPR031148, PF08337
Available protein structures: · 2
Plexin → IPR031148, PF08337
is a · 2
Plexin → only known receptor molecule to have a GAP domain, protein which acts as a receptor for semaphorin family signaling proteins
related to Role in intelligence · 2
Plexin → In, IQ
InterPro · 1
Plexin → IPR031148
Membranome · 1
Plexin → 17

Important terminology Word statistics

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Important terminology

semaphorin development plexins growth extracellular intracellular binding signaling plxnd1 axon domains cones well proteins structure domain protein activation cell effects

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
PlexinAlphaFoldIPR0311481.00infobox
PlexinAlphaFoldPF083371.00infobox
PlexinAvailable protein structures:IPR0311481.00infobox
PlexinAvailable protein structures:PF083371.00infobox
PlexinInterProIPR0311481.00infobox
PlexinMembranome171.00infobox
PlexinPDBIPR031148 PF08337 (ECOD; PDBsum)1.00infobox
PlexinPfamPF083371.00infobox
PlexinSymbolPLXN1.00infobox
Plexinis aprotein which acts as a receptor for semaphorin family signaling proteins0.90text
Plexinis aonly known receptor molecule to have a GAP domain0.90text
Plexinrelated to ClassesNine0.60section

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    Min side: 3
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