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Phosphodiesterase 3: Art, Regulation & Inhibitors

PDE3 is a phosphodiesterase. The PDEs belong to at least eleven related gene families, which are different in their primary structure, substrate affinity, responses to effectors, and regulation mechanism. Most of the PDE families are composed of more than one gene. PDE3 is clinically significant because of its role in regulating heart muscle, vascular…

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Phosphodiesterase 3 topic overview

The analysis highlights Art, Regulation and Inhibitors as prominent areas in the source structure around Phosphodiesterase 3.

Related topics
80
Source areas
11
Connected nodes
91
Extracted relationships
12
Concept neighborhoods
27
Bridge connections
91

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Regulation · 18 topics
Inhibitors · 12 topics
Function · 10 topics
Structure · 10 topics
Isoforms and genes · 8 topics
Overview · 6 topics
Tissue distribution · 6 topics
Active site · 3 topics
Asthma · 3 topics
Substrate affinity · 3 topics
Cancer · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Domains
InterPro
HGNC
8778
Locus
Chr. 12 p12
NCBI gene
5139
OMIM
123805
RefSeq
NM_000921

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Isoforms and genes

Tissue distribution

Regulation

Structure

Substrate affinity

Active site

Inhibitors

Cancer

Asthma

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Phosphodiesterase 3 connects Entity context

The extracted context around Phosphodiesterase 3 shows recurring relationship patterns in the source. For example, Phosphodiesterase 3 → InterPro Another extracted example is Phosphodiesterase 3 → 8778. Use these groups to spot repeated connection types before inspecting the individual relationships.

Phosphodiesterase 3

Top relations

Domains · 1
Phosphodiesterase 3 → InterPro
HGNC · 1
Phosphodiesterase 3 → 8778
Locus · 1
Phosphodiesterase 3 → Chr. 12 p12
NCBI gene · 1
Phosphodiesterase 3 → 5139
OMIM · 1
Phosphodiesterase 3 → 123805
RefSeq · 1
Phosphodiesterase 3 → NM_000921
Search for · 1
Phosphodiesterase 3 → Search forStructuresSwiss-modelDomainsInterPro
Structures · 1
Phosphodiesterase 3 → Swiss-model
Symbol · 1
Phosphodiesterase 3 → PDE3A
UniProt · 1
Phosphodiesterase 3 → Q14432

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

pde3 pde3b pde3a camp cgmp pdes different inhibitors two phosphorylation gene catalytic muscle smooth site structure affinity kinase residue substrate

Phosphodiesterase 3 relationships Subject–Predicate–Object triples

TTTA extracted 12 structured relationships around Phosphodiesterase 3. Examples in this analysis include Phosphodiesterase 3 → Domains → InterPro and Phosphodiesterase 3 → HGNC → 8778. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Phosphodiesterase 3DomainsInterPro1.00infobox
Phosphodiesterase 3HGNC87781.00infobox
Phosphodiesterase 3LocusChr. 12 p121.00infobox
Phosphodiesterase 3NCBI gene51391.00infobox
Phosphodiesterase 3OMIM1238051.00infobox
Phosphodiesterase 3RefSeqNM_0009211.00infobox
Phosphodiesterase 3Search forSearch forStructuresSwiss-modelDomainsInterPro1.00infobox
Phosphodiesterase 3StructuresSwiss-model1.00infobox
Phosphodiesterase 3SymbolPDE3A1.00infobox
Phosphodiesterase 3UniProtQ144321.00infobox
elevated cAMPinstance ofTheir expression in vascular smooth muscle is altered under specific conditions0.80text
hypoxiainstance ofTheir expression in vascular smooth muscle is altered under specific conditions0.80text

Related concept clusters Concept neighborhoods

The concept neighborhoods around Phosphodiesterase 3 bring nearby vocabulary together. In this analysis, examples include Families, Gene and Different. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • substrate affinity
    • Regulation
    • Active
    • Affinity
    • Gene
    • Structure
    • Substrate
    • Also
    • Site
    • Inhibitors
    • Cgmp
    • Genes
    • Families
  • pde3 inhibitors
    • Substrate
    • Also
    • Pde3a
    • Domain
    • Isoforms
    • Inhibitors
    • Pde3
    • Aggregation
    • Vascular
    • Smooth
    • Catalytic
    • Genes
  • substrate
    • Regulation
    • Active
    • Affinity
    • Gene
    • Structure
    • Site
    • Inhibitors
    • Genes
    • Families
    • Acid
    • Also
    • Domain
  • active site
    • Site
    • Binding
    • Substrate
    • Pde
    • Residue
    • Structure
    • Two
    • Genes
    • Regulation
    • Hydrophobic
    • Affinity
    • Also
  • gene families
    • Families
    • Gene
    • Different
    • Regulation
    • Pde
    • Substrate
    • Affinity
    • Structure
    • Pdes
    • Genes
    • Acid
    • N-terminal
  • primary structure
    • Regulation
    • Substrate
    • Active
    • Site
    • Catalytic
    • Genes
    • Domains
    • Hydrophobic
    • Acid
    • Also
    • Binding
    • Domain
  • crystal structure
    • Regulation
    • Substrate
    • Active
    • Site
    • Catalytic
    • Genes
    • Domains
    • Hydrophobic
    • Acid
    • Also
    • Binding
    • Domain
  • structure
    • Regulation
    • Substrate
    • Active
    • Site
    • Catalytic
    • Genes
    • Domains
    • Hydrophobic
    • Acid
    • Also
    • Binding
    • Domain

Connections between topic areas Semantic bridges

For Phosphodiesterase 3, one of the stronger structural bridges in this analysis connects Phosphodiesterase 3 with Regulation. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Phosphodiesterase 3 — Regulation · splits 73 ⟂ 19
Phosphodiesterase 3 — Inhibitors · splits 79 ⟂ 13
Phosphodiesterase 3 — Function · splits 81 ⟂ 11
Phosphodiesterase 3 — Structure · splits 81 ⟂ 11
Phosphodiesterase 3 — Isoforms and genes · splits 83 ⟂ 9
Phosphodiesterase 3 — Overview · splits 85 ⟂ 7
Phosphodiesterase 3 — Tissue distribution · splits 85 ⟂ 7
Phosphodiesterase 3 — Substrate affinity · splits 88 ⟂ 4
Phosphodiesterase 3 — Active site · splits 88 ⟂ 4
Phosphodiesterase 3 — Asthma · splits 88 ⟂ 4

Map overview Semantic statistics

Phosphodiesterase 3

Nodes92
Edges91
Triples12
Avg. degree1.98
Density0.021739
Components1

Source & methodology

TTTA analyzes the structure around Phosphodiesterase 3 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Art, Regulation & Inhibitors, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Phosphodiesterase 3 · EN edition · Analysis: TopicsToTalkAbout

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