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Peroxiredoxin

Peroxiredoxins (Prxs, EC 1.11.1.15; HGNC root symbol PRDX) are a ubiquitous family of antioxidant enzymes that also control cytokine-induced peroxide levels and thereby mediate signal transduction in mammalian cells. The family members in humans are PRDX1, PRDX2, PRDX3, PRDX4, PRDX5, and PRDX6. The physiological importance of peroxiredoxins is indicated…

Catalytic cycle, Classification & Overview

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Key facts & relationships

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AlphaFold
IPR000866 · PF00578
Available protein structures:
IPR000866 · PF00578
InterPro
IPR000866
OPM protein
1xvw
OPM superfamily
131
PDB
IPR000866 PF00578 (ECOD; PDBsum)

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Overview

Classification

Catalytic cycle

Enzyme regulation

Function

Circadian clock

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Map overview Semantic statistics

Peroxiredoxin

Nodes48
Edges47
Triples74
Avg. degree1.96
Density0.041667
Components1

How this topic connects Entity context

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Peroxiredoxin

Top relations

related to Classification · 24
Peroxiredoxin → AhpC/Prx1, AhpE, CP, CR, Cys, Cys Prx, Cys Prxs, Family, GenBank, It, January, Moreover, October, Prx, Prx5, Prx6, PrxQ/BCP, Prxs, PrxVI, The
related to Catalytic cycle · 13
Peroxiredoxin → AhpC, Cys, GST-π, Other, Peroxiredoxins, Prxs, RSO2H, The, These, This, TPx, TSA, Using
related to Peroxiredoxin-like · 10
Peroxiredoxin → CxxC, In, InterPro, IPR032801, Mammals, PRXL2A, PRXL2B, PRXL2C, The, These
related to Function · 3
Peroxiredoxin → H2O2, Prx, Trx
AlphaFold · 2
Peroxiredoxin → IPR000866, PF00578
Available protein structures: · 2
Peroxiredoxin → IPR000866, PF00578
InterPro · 1
Peroxiredoxin → IPR000866
OPM protein · 1
Peroxiredoxin → 1xvw
OPM superfamily · 1
Peroxiredoxin → 131
PDB · 1
Peroxiredoxin → IPR000866 PF00578 (ECOD; PDBsum)

Important terminology Word statistics

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Important terminology

peroxiredoxins 2-cys prxs family peroxide members also enzymes cysteine thiol knockout 1-cys prx cr mice function typical acid one abundant

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
PeroxiredoxinAlphaFoldIPR0008661.00infobox
PeroxiredoxinAlphaFoldPF005781.00infobox
PeroxiredoxinAvailable protein structures:IPR0008661.00infobox
PeroxiredoxinAvailable protein structures:PF005781.00infobox
PeroxiredoxinInterProIPR0008661.00infobox
PeroxiredoxinOPM protein1xvw1.00infobox
PeroxiredoxinOPM superfamily1311.00infobox
PeroxiredoxinPDBIPR000866 PF00578 (ECOD; PDBsum)1.00infobox
PeroxiredoxinPfamPF005781.00infobox
PeroxiredoxinPfam clanCL01721.00infobox
PeroxiredoxinSCOP21prx / SCOPe / SUPFAM1.00infobox
PeroxiredoxinSymbolAhpC-TSA1.00infobox

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    Min side: 3
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