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Phosphodiesterase 3

PDE3 is a phosphodiesterase. The PDEs belong to at least eleven related gene families, which are different in their primary structure, substrate affinity, responses to effectors, and regulation mechanism. Most of the PDE families are composed of more than one gene. PDE3 is clinically significant because of its role in regulating heart muscle, vascular…

Art, Regulation & Inhibitors

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Key facts & relationships

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Domains
InterPro
HGNC
8778
Locus
Chr. 12 p12
NCBI gene
5139
OMIM
123805
RefSeq
NM_000921

Topics to explore

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Overview

Function

Isoforms and genes

Tissue distribution

Regulation

Structure

Substrate affinity

Active site

Inhibitors

Cancer

Asthma

Advanced semantic analysis

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Map overview Semantic statistics

Phosphodiesterase 3

Nodes92
Edges91
Triples12
Avg. degree1.98
Density0.021739
Components1

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Phosphodiesterase 3

Top relations

Domains · 1
Phosphodiesterase 3 → InterPro
HGNC · 1
Phosphodiesterase 3 → 8778
Locus · 1
Phosphodiesterase 3 → Chr. 12 p12
NCBI gene · 1
Phosphodiesterase 3 → 5139
OMIM · 1
Phosphodiesterase 3 → 123805
RefSeq · 1
Phosphodiesterase 3 → NM_000921
Search for · 1
Phosphodiesterase 3 → Search forStructuresSwiss-modelDomainsInterPro
Structures · 1
Phosphodiesterase 3 → Swiss-model
Symbol · 1
Phosphodiesterase 3 → PDE3A
UniProt · 1
Phosphodiesterase 3 → Q14432

Important terminology Word statistics

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Important terminology

pde3 pde3b pde3a camp cgmp pdes different inhibitors two phosphorylation gene catalytic muscle smooth site structure affinity kinase residue substrate

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Phosphodiesterase 3DomainsInterPro1.00infobox
Phosphodiesterase 3HGNC87781.00infobox
Phosphodiesterase 3LocusChr. 12 p121.00infobox
Phosphodiesterase 3NCBI gene51391.00infobox
Phosphodiesterase 3OMIM1238051.00infobox
Phosphodiesterase 3RefSeqNM_0009211.00infobox
Phosphodiesterase 3Search forSearch forStructuresSwiss-modelDomainsInterPro1.00infobox
Phosphodiesterase 3StructuresSwiss-model1.00infobox
Phosphodiesterase 3SymbolPDE3A1.00infobox
Phosphodiesterase 3UniProtQ144321.00infobox
elevated cAMPinstance ofTheir expression in vascular smooth muscle is altered under specific conditions0.80text
hypoxiainstance ofTheir expression in vascular smooth muscle is altered under specific conditions0.80text

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    Min side: 3
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