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Paroxetine

Paroxetine, sold under the brand name Paxil among others, is an antidepressant medication of the selective serotonin reuptake inhibitor (SSRI) class used to treat major depressive disorder, obsessive–compulsive disorder (OCD), panic disorder, social anxiety disorder, post-traumatic stress disorder (PTSD), generalized anxiety disorder, and premenstrual…

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Explore the main themes, entities and connections around Paroxetine. Start with the topic map, then use the sections below for research and deeper semantic analysis.

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Key facts & relationships

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3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
N06AB05 (WHO)
Bioavailability
50%
CAS Number
61869-08-7 Y
ChEBI
CHEBI:7936 N

Topics to explore

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Overview

Medical uses

Adverse effects

Overdose

Interactions

Pharmacology

Society and culture

Research

Other organisms

Advanced semantic analysis

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Map overview Semantic statistics

Paroxetine

Nodes125
Edges124
Triples145
Avg. degree1.98
Density0.016
Components1

How this topic connects Entity context

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Paroxetine

Top relations

has effect · 13
Paroxetine → Common, FAA, FAA Authorization, SC, Serious, SI, SNRIs, Special Consideration, Special Issuance, SSRIs, The Federal Aviation Administration, Use, While
related to Discontinuation syndrome · 10
Paroxetine → Another, Common, FDA, Glaxo, GSK, In, International Federation, Many, Pharmaceutical Manufacturers Associations, The
related to Marketing · 10
Paroxetine → GlaxoSmithKline, GSK, GSK's, In, It, Justice, One, Paxil, The, United States Department
related to Post-SSRI sexual dysfunction · 9
Paroxetine → Characteristic, In, PSSD, Severe, SSRI, SSRIs, The, The DSM-5, While
related to Interactions · 8
Paroxetine → Interactions, MAO, MAOI, NMS, SNRIs, SSRIs, Such, The
related to Pregnancy · 7
Paroxetine → Antidepressant, Apgar, Babies, Gynecologists, Obstetricians, The American College, Unless
Legal status · 6
Paroxetine → AU: S4 (Prescription only), BR: Class C1 (Other controlled substances), CA: ℞-only, In general: ℞ (Prescription only), UK: POM (Prescription only), US: ℞-only
related to Society and culture · 6
Paroxetine → Essential Medicines, GlaxoSmithKline, In, It, United States, World Health Organization's List
related to Overdose · 5
Paroxetine → Acute, Along, Plasma, Postmortem, SSRIs
related to Suicide · 5
Paroxetine → In, Like, Study, The BMJ, The FDA

Important terminology Word statistics

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Important terminology

may treatment effects also sexual dysfunction serotonin ssris disorder states use inhibitor united anxiety risk used side include discontinuation syndrome

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Paroxetine3D model (JSmol)Interactive image1.00infobox
ParoxetineAHFS/Drugs.comMonograph1.00infobox
ParoxetineATC codeN06AB05 (WHO)1.00infobox
ParoxetineBioavailability50%1.00infobox
ParoxetineCAS Number61869-08-7 Y1.00infobox
ParoxetineChEBICHEBI:7936 N1.00infobox
ParoxetineChEMBLChEMBL490 Y1.00infobox
ParoxetineChemSpider39888 Y1.00infobox
ParoxetineCompTox Dashboard (EPA)DTXSID30234251.00infobox
ParoxetineDrug classSelective serotonin reuptake inhibitor (SSRI)1.00infobox
ParoxetineDrugBankDB00715 Y1.00infobox
ParoxetineECHA InfoCard100.112.0961.00infobox
ParoxetineElimination half-life21 hours1.00infobox
ParoxetineExcretionKidney (64%; 2% unchanged and 62% as metabolites), faecal (36%; <1% unchanged)1.00infobox
ParoxetineFormulaC19H20FNO31.00infobox
ParoxetineIUPHAR/BPS47901.00infobox
ParoxetineKEGGD02362 Y1.00infobox
ParoxetineLegal statusAU: S4 (Prescription only)1.00infobox
ParoxetineLegal statusBR: Class C1 (Other controlled substances)1.00infobox
ParoxetineLegal statusCA: ℞-only1.00infobox
ParoxetineLegal statusUK: POM (Prescription only)1.00infobox
ParoxetineLegal statusUS: ℞-only1.00infobox
ParoxetineLegal statusIn general: ℞ (Prescription only)1.00infobox
ParoxetineLicense dataUS DailyMed: Paroxetine1.00infobox
ParoxetineMedlinePlusa6980321.00infobox
ParoxetineMetabolismExtensive, liver (mostly CYP2D6-mediated)1.00infobox
ParoxetineMolar mass329.371 g·mol−11.00infobox
ParoxetinePregnancy categoryAU: D1.00infobox
ParoxetinePronunciation/pərˈɑːksəˌtin/ pər-AHK-sə-TEEN1.00infobox
ParoxetineProtein binding93–95%1.00infobox

Related concept clusters Concept neighborhoods

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