Research any topic before you write.

Find related topics. | Discover entities. | See connections. | Build a topical map.

Study 329

Study 329 was a clinical trial which was conducted in North America from 1994 to 1998 to study the efficacy of paroxetine, an SSRI anti-depressant, in treating 12- to 18-year-olds diagnosed with major depressive disorder. Led by Martin Keller, then professor of psychiatry at Brown University, and funded by the British pharmaceutical company SmithKline…

Art, Standards & Companies

Use the mouse wheel or two fingers (on touchscreens) to zoom in and out of the map.

Research this topic

Explore the main themes, entities and connections around Study 329. Start with the topic map, then use the sections below for research and deeper semantic analysis.

Explore this topic

Start with a few of the strongest sections from the source topic. These are research directions, not a list of keywords you must use.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Call for retraction
May 2003, April 2013
Dates
1994–1998
Disputed article
Martin B. Keller, et al. (July 2001). "Efficacy of paroxetine in the treatment of adolescent major depression: a randomized, controlled trial", Journal of the American Academy o…
Funding
SmithKline Beecham, now GlaxoSmithKline (GSK)
Lead researcher
Martin Keller, then professor of psychiatry, Brown University
Legal penalty
GSK fined in 2012 by US Department of Justice

Topics to explore

Browse the full topic structure. Each item opens a new analysis centered on that subject.

Overview

Clinical trial

1998 SmithKline Beecham position paper

JAACAP article

Inquiries in the United Kingdom

Inquiries in the United States

Calls for retraction

RIAT re-analysis of study 329

Anti-depressants and suicidality in young people

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

Map overview Semantic statistics

Study 329

Nodes71
Edges70
Triples168
Avg. degree1.97
Density0.028169
Components1

How this topic connects Entity context

See the strongest relationship patterns around the current topic before diving into the raw triples.

Study 329

Top relations

related to Authorship · 21
Study 329 → Although, Editorial, GSK, In April, JAACAP, James, John, Laden, March, Martin Keller, McCafferty, New Jersey, PR, Romankiewicz, Sally, Scientific Therapeutics Information, SmithKline Beecham, Springfield, STI, The
related to 2001 GlaxoSmithKline sales memo, off-label use · 18
Study 329 → All Sales Representatives Selling, August, Drug, GSK, GSK's Paxil Product Management, In, JAACAP, Keller, On, Paxil, REMARKABLE Efficacy, Safety, Sally Laden, STI, The, UK, US, Zachary Hawkins
related to Calls for retraction · 18
Study 329 → Adelaide, American Psychiatric Association, Ann Tonkin, Child, Children's Hospital, Dulcan, GSK, In, JAACAP, JAACAP's, Jon Jureidini, Keller, Leemon McHenry, McHenry, Mina Dulcan, The Boston Globe, University, Women's
related to BBC Panorama, MHRA · 17
Study 329 → BBC Panorama, Donald Schell, Drug Trials, GSK, January, Jofre's, July, Schell, Scottish, Secrets, Shelley Jofre, SmithKline Beecham Pharmaceuticals, The, Timothy, Tobin, United States, Wyoming
related to overview · 16
Study 329 → After, April, Brown University, Canada, Funded, Martin Keller, May, October, Of, Paxil, Seroxat, SmithKline Beecham, SSRIs, The, Tofranil, United States
related to The Boston Globe · 16
Study 329 → Alison Bass, Bass's, Bestselling Antidepressant, Brown University's, GlaxoSmithKline, In November, In October, Keller's, Martin Keller, Prosecutor, Side Effects, Study, The Boston Globe, There, Trial, Whistleblower
related to People v. GlaxoSmithKline · 15
Study 329 → AllTrials, August, British, By October, Court, December, Eli Lilly, Eliot Spitzer, GSK, In, In June, Merck, New York State Attorney, New York State Supreme, Pfizer
related to RIAT re-analysis of study 329 · 15
Study 329 → BMJ, Catalin Tufanaru, David Healy, Elia Abi-Jaoude, In July, Joanna Le Noury, John, Jon Jureidini, Jureidini, Melissa Raven, Nardo, RIAT, September, The RIAT, They
related to United States v. GlaxoSmithKline · 10
Study 329 → False Claims Act, FDA, GSK, In October, JAACAP, Justice, Medicaid, Paxil, The, United States Department
related to FDA-mandated review · 9
Study 329 → Adolescents, FDA, GSK, In, In March, MDD, SSRIs, The, They

Important terminology Word statistics

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

paroxetine gsk study placebo 329 efficacy article data mhra drug smithkline clinical beecham depression safety jaacap trial children imipramine trials

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Study 329Call for retractionMay 2003, April 20131.00infobox
Study 329Dates1994–19981.00infobox
Study 329Disputed articleMartin B. Keller, et al. (July 2001). "Efficacy of paroxetine in the treatment of adolescent major depression: a randomized, controlled trial", Journal of the American Academy o…1.00infobox
Study 329FundingSmithKline Beecham, now GlaxoSmithKline (GSK)1.00infobox
Study 329Lead researcherMartin Keller, then professor of psychiatry, Brown University1.00infobox
Study 329Legal penaltyGSK fined in 2012 by US Department of Justice1.00infobox
Study 329Locations10 centres in the United States, two in Canada1.00infobox
Study 329Protocol"Study drug: BRL29060/Paroxetine (Paxil)", SmithKline Beecham, 20 August 1993, amended 24 March 1994.1.00infobox
Study 329PublishedJuly 20011.00infobox
Study 329RetractedNo1.00infobox
Study 329Study reanalysisJoanna Le Noury, et al. (16 September 2015). "Restoring Study 329: efficacy and harms of paroxetine and imipramine in treatment of major depression in adolescence", BMJ, 351, 16…1.00infobox
Study 329Study typeEight-week, placebo-controlled, double-blind, randomized clinical trial comparing paroxetine with imipramine in adolescents with major depressive disorder1.00infobox

Related concept clusters Concept neighborhoods

These clusters group vocabulary that occurs around closely connected concepts in the source material.

    Connections between topic areas Semantic bridges

    Bridges can reveal useful research angles that are easy to miss in a flat list of related terms.

    Min side: 3
    For writers, content strategists, SEOs, marketers and creators — from quick topic research to advanced semantic analysis.