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Study 329: Art, Standards & Companies

Study 329 was a clinical trial which was conducted in North America from 1994 to 1998 to study the efficacy of paroxetine, an SSRI anti-depressant, in treating 12- to 18-year-olds diagnosed with major depressive disorder. Led by Martin Keller, then professor of psychiatry at Brown University, and funded by the British pharmaceutical company SmithKline…

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Study 329 topic overview

The analysis highlights Art, Standards and Companies as prominent areas in the source structure around Study 329.

Related topics
61
Source areas
9
Connected nodes
70
Extracted relationships
151
Related term clusters
22
Bridge connections
70

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 25 topics
Inquiries in the United States · 10 topics
Inquiries in the United Kingdom · 9 topics
Calls for retraction · 6 topics
Clinical trial · 5 topics
Anti-depressants and suicidality in young people · 3 topics
1998 SmithKline Beecham position paper · 1 topics
JAACAP article · 1 topics
RIAT re-analysis of study 329 · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Call for retraction
May 2003, April 2013
Dates
1994–1998
Disputed article
Martin B. Keller, et al. (July 2001). "Efficacy of paroxetine in the treatment of adolescent major depression: a randomized, controlled trial", Journal of the American Academy o…
Funding
SmithKline Beecham, now GlaxoSmithKline (GSK)
Lead researcher
Martin Keller, then professor of psychiatry, Brown University
Legal penalty
GSK fined in 2012 by US Department of Justice

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Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Clinical trial

1998 SmithKline Beecham position paper

JAACAP article

Inquiries in the United Kingdom

Inquiries in the United States

Calls for retraction

RIAT re-analysis of study 329

Anti-depressants and suicidality in young people

For the semantics nerds

You can skip this section if you’re here for content ideas and keyword inspiration.

Advanced semantic analysis

How Study 329 connects Entity context

The extracted context around Study 329 shows recurring relationship patterns in the source. For example, Study 329 → Although, Editorial, GSK, In April, JAACAP, James, John, Laden, March, Martin Keller, McCafferty, New Jersey, PR, Romankiewicz, Sally, Scientific Therapeutics Information, SmithKline Beecham, Springfield, STI, The JAACAP Another extracted example is Study 329 → Adelaide, American Psychiatric Association, Ann Tonkin, Child, Children's Hospital, Dulcan, GSK, JAACAP, JAACAP's, Jon Jureidini, Keller, Leemon McHenry, McHenry, Mina Dulcan, The Boston Globe, University, Women's. Use these groups to spot repeated connection types before inspecting the individual relationships.

Study 329

Top relations

related to Authorship · 20
Study 329 → Although, Editorial, GSK, In April, JAACAP, James, John, Laden, March, Martin Keller, McCafferty, New Jersey, PR, Romankiewicz, Sally, Scientific Therapeutics Information, SmithKline Beecham, Springfield, STI, The JAACAP
related to Calls for retraction · 17
Study 329 → Adelaide, American Psychiatric Association, Ann Tonkin, Child, Children's Hospital, Dulcan, GSK, JAACAP, JAACAP's, Jon Jureidini, Keller, Leemon McHenry, McHenry, Mina Dulcan, The Boston Globe, University, Women's
related to BBC Panorama, MHRA · 16
Study 329 → BBC Panorama, Donald Schell, Drug Trials, GSK, January, Jofre's, July, Schell, Scottish, Secrets, Shelley Jofre, SmithKline Beecham Pharmaceuticals, Timothy, Tobin, United States, Wyoming
related to 2001 GlaxoSmithKline sales memo, off-label use · 15
Study 329 → All Sales Representatives Selling, August, Drug, GSK, GSK's Paxil Product Management, JAACAP, Keller, Paxil, REMARKABLE Efficacy, Safety, Sally Laden, STI, UK, US, Zachary Hawkins
related to The Boston Globe · 15
Study 329 → Alison Bass, Bass's, Bestselling Antidepressant, Brown University's, GlaxoSmithKline, In November, In October, Keller's, Martin Keller, Prosecutor, Side Effects, Study, The Boston Globe, Trial, Whistleblower
related to People v. GlaxoSmithKline · 14
Study 329 → AllTrials, August, British, By October, Court, December, Eli Lilly, Eliot Spitzer, GSK, In June, Merck, New York State Attorney, New York State Supreme, Pfizer
related to RIAT re-analysis of study 329 · 14
Study 329 → BMJ, Catalin Tufanaru, David Healy, Elia Abi-Jaoude, In July, Joanna Le Noury, John, Jon Jureidini, Jureidini, Melissa Raven, Nardo, RIAT, September, The RIAT
related to overview · 13
Study 329 → April, Brown University, Canada, Funded, Martin Keller, May, October, Paxil, Seroxat, SmithKline Beecham, SSRIs, Tofranil, United States
related to United States v. GlaxoSmithKline · 9
Study 329 → False Claims Act, FDA, GSK, In October, JAACAP, Justice, Medicaid, Paxil, United States Department
related to FDA-mandated review · 6
Study 329 → Adolescents, FDA, GSK, In March, MDD, SSRIs

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

paroxetine gsk study placebo 329 efficacy article data mhra drug smithkline clinical beecham depression safety jaacap trial children imipramine trials

Study 329 relationships Subject–Predicate–Object triples

TTTA extracted 151 structured relationships around Study 329. Examples in this analysis include Study 329 → Call for retraction → May 2003, April 2013 and Study 329 → Dates → 1994–1998. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Study 329Call for retractionMay 2003, April 20131.00infobox
Study 329Dates1994–19981.00infobox
Study 329Disputed articleMartin B. Keller, et al. (July 2001). "Efficacy of paroxetine in the treatment of adolescent major depression: a randomized, controlled trial", Journal of the American Academy o…1.00infobox
Study 329FundingSmithKline Beecham, now GlaxoSmithKline (GSK)1.00infobox
Study 329Lead researcherMartin Keller, then professor of psychiatry, Brown University1.00infobox
Study 329Legal penaltyGSK fined in 2012 by US Department of Justice1.00infobox
Study 329Locations10 centres in the United States, two in Canada1.00infobox
Study 329Protocol"Study drug: BRL29060/Paroxetine (Paxil)", SmithKline Beecham, 20 August 1993, amended 24 March 1994.1.00infobox
Study 329PublishedJuly 20011.00infobox
Study 329Study reanalysisJoanna Le Noury, et al. (16 September 2015). "Restoring Study 329: efficacy and harms of paroxetine and imipramine in treatment of major depression in adolescence", BMJ, 351, 16…1.00infobox
Study 329Study typeEight-week, placebo-controlled, double-blind, randomized clinical trial comparing paroxetine with imipramine in adolescents with major depressive disorder1.00infobox
aggressioninstance oftwo conduct problems0.80text

Related concept clusters Related term clusters

The concept neighborhoods around Study 329 bring nearby vocabulary together. In this analysis, examples include Efficacy, Paxil and Trial. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Study 329
    • Efficacy
    • Paxil
    • Trial
    • Paroxetine
    • Adolescent
    • Beecham
    • Psychiatry
    • Depression
    • Smithkline
    • Placebo
    • Article
    • Gsk
  • study 329
    • Efficacy
    • Paxil
    • Trial
    • Paroxetine
    • Adolescent
    • Beecham
    • Psychiatry
    • Depression
    • Smithkline
    • Placebo
    • Article
    • Gsk
  • clinical trial
    • Trial
    • Trials
    • Gsk
    • Mhra
    • Data
    • Efficacy
    • United
    • Depression
    • Smithkline
    • Children
    • Drug
    • States
  • paroxetine
    • Placebo
    • Gsk
    • Study
    • Imipramine
    • Depression
    • Concluded
    • Adolescents
    • Children
    • Treatment
    • Article
    • Trial
    • Data
  • martin keller
    • Psychiatry
    • Beecham
    • Jaacap
    • Article
    • Smithkline
    • Published
    • Company
    • Study
    • Trial
    • Gsk
    • Adolescent
    • Imipramine
  • smithkline beecham
    • Smithkline
    • Paper
    • Trial
    • United
    • States
    • Study
    • Adolescent
    • Keller
    • Jaacap
    • Efficacy
    • Depression
    • Psychiatry
  • imipramine
    • Placebo
    • Paroxetine
    • Concluded
    • Treatment
    • Patients
    • Study
    • Depression
    • Smithkline
    • United
    • Psychiatry
    • States
    • Behaviour
  • placebo
    • Paxil
    • Patients
    • Depression
    • Behaviour
    • Study
    • Suicidal
    • Treatment
    • Adolescent
    • Paper
    • Safety
    • Concluded
    • Seroxat

Connections between topic areas Semantic bridges

For Study 329, one of the stronger structural bridges in this analysis connects Study 329 with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Study 329 — Overview · splits 45 ⟂ 26
Study 329 — Inquiries in the United States · splits 60 ⟂ 11
Study 329 — Inquiries in the United Kingdom · splits 61 ⟂ 10
Study 329 — Calls for retraction · splits 64 ⟂ 7
Study 329 — Clinical trial · splits 65 ⟂ 6
Study 329 — Anti-depressants and suicidality in young people · splits 67 ⟂ 4

Map overview Semantic statistics

Study 329

Nodes71
Edges70
Triples151
Avg. degree1.97
Density0.028169
Components1

Source & methodology

TTTA analyzes the structure around Study 329 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Art, Standards & Companies, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Study 329 · EN edition · Analysis: TopicsToTalkAbout

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