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Study 329 was a clinical trial which was conducted in North America from 1994 to 1998 to study the efficacy of paroxetine, an SSRI anti-depressant, in treating 12- to 18-year-olds diagnosed with major depressive disorder. Led by Martin Keller, then professor of psychiatry at Brown University, and funded by the British pharmaceutical company SmithKline…
The analysis highlights Art, Standards and Companies as prominent areas in the source structure around Study 329.
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Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
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The extracted context around Study 329 shows recurring relationship patterns in the source. For example, Study 329 → Although, Editorial, GSK, In April, JAACAP, James, John, Laden, March, Martin Keller, McCafferty, New Jersey, PR, Romankiewicz, Sally, Scientific Therapeutics Information, SmithKline Beecham, Springfield, STI, The JAACAP Another extracted example is Study 329 → Adelaide, American Psychiatric Association, Ann Tonkin, Child, Children's Hospital, Dulcan, GSK, JAACAP, JAACAP's, Jon Jureidini, Keller, Leemon McHenry, McHenry, Mina Dulcan, The Boston Globe, University, Women's. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
paroxetine gsk study placebo 329 efficacy article data mhra drug smithkline clinical beecham depression safety jaacap trial children imipramine trials
TTTA extracted 151 structured relationships around Study 329. Examples in this analysis include Study 329 → Call for retraction → May 2003, April 2013 and Study 329 → Dates → 1994–1998. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| Study 329 | Call for retraction | May 2003, April 2013 | 1.00 | infobox |
| Study 329 | Dates | 1994–1998 | 1.00 | infobox |
| Study 329 | Disputed article | Martin B. Keller, et al. (July 2001). "Efficacy of paroxetine in the treatment of adolescent major depression: a randomized, controlled trial", Journal of the American Academy o… | 1.00 | infobox |
| Study 329 | Funding | SmithKline Beecham, now GlaxoSmithKline (GSK) | 1.00 | infobox |
| Study 329 | Lead researcher | Martin Keller, then professor of psychiatry, Brown University | 1.00 | infobox |
| Study 329 | Legal penalty | GSK fined in 2012 by US Department of Justice | 1.00 | infobox |
| Study 329 | Locations | 10 centres in the United States, two in Canada | 1.00 | infobox |
| Study 329 | Protocol | "Study drug: BRL29060/Paroxetine (Paxil)", SmithKline Beecham, 20 August 1993, amended 24 March 1994. | 1.00 | infobox |
| Study 329 | Published | July 2001 | 1.00 | infobox |
| Study 329 | Study reanalysis | Joanna Le Noury, et al. (16 September 2015). "Restoring Study 329: efficacy and harms of paroxetine and imipramine in treatment of major depression in adolescence", BMJ, 351, 16… | 1.00 | infobox |
| Study 329 | Study type | Eight-week, placebo-controlled, double-blind, randomized clinical trial comparing paroxetine with imipramine in adolescents with major depressive disorder | 1.00 | infobox |
| aggression | instance of | two conduct problems | 0.80 | text |
The concept neighborhoods around Study 329 bring nearby vocabulary together. In this analysis, examples include Efficacy, Paxil and Trial. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For Study 329, one of the stronger structural bridges in this analysis connects Study 329 with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around Study 329 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Art, Standards & Companies, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — Study 329 · EN edition · Analysis: TopicsToTalkAbout