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Palbociclib

Palbociclib, sold under the brand name Ibrance among others, is an anti-cancer medication used for the treatment of HR-positive and HER2-negative breast cancer. It was developed by Pfizer. It is a selective inhibitor of the cyclin-dependent kinases CDK4 and CDK6. Palbociclib was the first CDK4/6 inhibitor to be approved as a cancer therapy.

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3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
L01EF01 (WHO)
Bioavailability
46%
CAS Number
571190-30-2
ChEBI
CHEBI:85993

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Overview

Medical uses

Adverse effects

Mechanisms of resistance

Mechanism of action

Clinical trials

Drugs with a similar mechanism of action

Society and culture

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Map overview Semantic statistics

Palbociclib

Nodes83
Edges82
Triples166
Avg. degree1.98
Density0.024096
Components1

How this topic connects Entity context

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Palbociclib

Top relations

related to Other mechanisms of resistance · 21
Palbociclib → CCNE1/RB, CDK4, CDK4/6, CDK6, D1/CDK2, Dana Farber Institute, E1, E2, Evidence, For, Furthermore, On, Previous, Rb, Researchers, S-phase, Scientists, TGF-β, There, These
related to De novo resistance · 16
Palbociclib → Brk, CDK4, CDK4/6, CDK4/6-Rb, De, E1, E2, E2F2, FAT1, Hippo, Loss, Overexpression, Previously, Rb, The, Y88
related to Resistance due to endocrine therapy · 16
Palbociclib → Because CDK4/6, CDK4, CDK4/6, Certain, CHK2-mediated, ER, ESR1, For, HER2, HR, In, MutL, MutL-defective ER, PALOMA-3, PFS, Such
related to Drugs with a similar mechanism of action · 12
Palbociclib → CDK4/6, Cyclin D3/CDK6, Eli Lilly, FDA, February, G1 Therapeutics, HER2-negative, HR-positive, In March, In September, Notably, Novartis
related to Legal status · 12
Palbociclib → Breakthrough Therapy, Drug Administration's, ER, FDA, February, HER2, HR, In March, Priority Review, The, This, US Food
related to Mechanism of action · 12
Palbociclib → CDK4, CDK4/6, CDK6, Cyclin, D-CDK4/6, G1, However, In, It, Rb, Regulation, This
related to Active clinical trials · 9
Palbociclib → According, CDK4/6, III, In December, NIH National Cancer Institute, PALOMA-2, Pfizer, The, While
related to Resistance to palbociclib · 8
Palbociclib → EMA-approval, FDA, For, However, OS, PALOMA-2, PFS, This
related to Economics · 7
Palbociclib → According, Ibrance, In, New York, Pfizer, United States, US
related to HR+ breast cancer · 6
Palbociclib → American Association, April, Cancer Research, II PALOMA-1, In, The PALOMA-3

Important terminology Word statistics

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Important terminology

cdk4 cancer breast resistance therapy patients inhibitor combination treatment cells endocrine fulvestrant effects also survival trial pfizer anemia advanced cell

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Palbociclib3D model (JSmol)Interactive image1.00infobox
PalbociclibAHFS/Drugs.comMonograph1.00infobox
PalbociclibATC codeL01EF01 (WHO)1.00infobox
PalbociclibBioavailability46%1.00infobox
PalbociclibCAS Number571190-30-21.00infobox
PalbociclibChEBICHEBI:859931.00infobox
PalbociclibChEMBLChEMBL1899631.00infobox
PalbociclibChemSpider44874371.00infobox
PalbociclibCompTox Dashboard (EPA)DTXSID409725901.00infobox
PalbociclibDrugBankDB090731.00infobox
PalbociclibECHA InfoCard100.238.2211.00infobox
PalbociclibElimination half-life29 (±5) hours1.00infobox
PalbociclibExcretion74% feces, 18% urine1.00infobox
PalbociclibFormulaC24H29N7O21.00infobox
PalbociclibKEGGD103721.00infobox
PalbociclibLegal statusAU: S4 (Prescription only)1.00infobox
PalbociclibLegal statusCA: ℞-only1.00infobox
PalbociclibLegal statusUK: POM (Prescription only)1.00infobox
PalbociclibLegal statusUS: ℞-only1.00infobox
PalbociclibLegal statusEU: Rx-only1.00infobox
PalbociclibLicense dataUS DailyMed: Palbociclib1.00infobox
PalbociclibMedlinePlusa6150131.00infobox
PalbociclibMetabolismLiver (CYP3A, SULT2A1, glucuronidation)1.00infobox
PalbociclibMolar mass447.543 g·mol−11.00infobox
PalbociclibOther namesPD-03329911.00infobox
PalbociclibPDB ligandLQQ (PDBe, RCSB PDB)1.00infobox
PalbociclibPregnancy categoryAU: D1.00infobox
PalbociclibPronunciation/ˌpælboʊˈsaɪklɪb/ PAL-boh-SYE-klib1.00infobox
PalbociclibProtein binding85%1.00infobox
PalbociclibPubChem CID53302861.00infobox

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