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P2RX4: Measurement, Structure & Receptor trafficking

P2X purinoceptor 4 is a protein that in humans is encoded by the P2RX4 gene. P2X purinoceptor 4 is a member of the P2X receptor family. P2X receptors are trimeric protein complexes that can be homomeric or heteromeric. These receptors are ligand-gated cation channels that open in response to ATP binding. Each receptor subtype, determined by the subunit…

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P2RX4 topic overview

The analysis highlights Measurement, Structure and Receptor trafficking as prominent areas in the source structure around P2RX4.

Related topics
68
Source areas
6
Connected nodes
74
Extracted relationships
124
Concept neighborhoods
21
Bridge connections
74

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 22 topics
Structure · 14 topics
Receptor trafficking · 12 topics
Gating mechanism · 8 topics
Neuropathic pain · 7 topics
Pharmacology · 5 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
P2RX4, P2X4, P2X4R, purinergic receptor P2X 4
Band
12q24.31 · 5 F|5 62.53 cM
Bgee
mucosa of transverse colon · cerebellar hemisphere · right hemisphere of cerebellum · granulocyte · body of pancreas
BioGPS
More reference expression data
Chr.
Chromosome 12 (human) · Chromosome 5 (mouse)
Databases
NCBI: entry; OMA: entry

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure

Gating mechanism

Receptor trafficking

Pharmacology

Neuropathic pain

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How P2RX4 connects Entity context

The extracted context around P2RX4 shows recurring relationship patterns in the source. For example, P2RX4 → apoptotic signaling pathway, ATP binding, axon, blood coagulation, cadherin binding, cation transmembrane transport, cell junction, cellular response to ATP, copper ion binding, dendrite, dendritic spine, endothelial cell activation, excitatory postsynaptic potential, extracellular exosome, extracellularly ATP-gated cation channel activity, identical protein binding, integral component of membrane, integral component of nuclear inner membrane, integral component of plasma membrane, ion channel activity Another extracted example is P2RX4 → body of pancreas, cerebellar hemisphere, decidua, granulocyte, Ileal epithelium, lacrimal gland, left colon, lesser wing of sphenoid bone, monocyte, mucosa of ileum, mucosa of sigmoid colon, mucosa of transverse colon, nasal septum, parotid gland, rectum, right hemisphere of cerebellum, stroma of bone marrow, stromal cell of endometrium, submandibular gland, yolk sac. Use these groups to spot repeated connection types before inspecting the individual relationships.

P2RX4

Top relations

Gene ontology · 58
P2RX4 → apoptotic signaling pathway, ATP binding, axon, blood coagulation, cadherin binding, cation transmembrane transport, cell junction, cellular response to ATP, copper ion binding, dendrite, dendritic spine, endothelial cell activation, excitatory postsynaptic potential, extracellular exosome, extracellularly ATP-gated cation channel activity, identical protein binding, integral component of membrane, integral component of nuclear inner membrane, integral component of plasma membrane, ion channel activity
Bgee · 20
P2RX4 → body of pancreas, cerebellar hemisphere, decidua, granulocyte, Ileal epithelium, lacrimal gland, left colon, lesser wing of sphenoid bone, monocyte, mucosa of ileum, mucosa of sigmoid colon, mucosa of transverse colon, nasal septum, parotid gland, rectum, right hemisphere of cerebellum, stroma of bone marrow, stromal cell of endometrium, submandibular gland, yolk sac
RNA expression pattern · 20
P2RX4 → body of pancreas, cerebellar hemisphere, decidua, granulocyte, Ileal epithelium, lacrimal gland, left colon, lesser wing of sphenoid bone, monocyte, mucosa of ileum, mucosa of sigmoid colon, mucosa of transverse colon, nasal septum, parotid gland, rectum, right hemisphere of cerebellum, stroma of bone marrow, stromal cell of endometrium, submandibular gland, yolk sac
related to External links · 6
P2RX4 → Medicine, Medicine Medical Subject Headings, MeSH, National Library, This, United States National Library
Band · 2
P2RX4 → 12q24.31, 5 F|5 62.53 cM
Chr. · 2
P2RX4 → Chromosome 12 (human), Chromosome 5 (mouse)
End · 2
P2RX4 → 121,234,106 bp, 122,867,801 bp
Aliases · 1
P2RX4 → P2RX4, P2X4, P2X4R, purinergic receptor P2X 4
BioGPS · 1
P2RX4 → More reference expression data
Databases · 1
P2RX4 → NCBI: entry; OMA: entry

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

receptor receptors p2x4 p2x desensitization cell human bp gene atp protein activation chr band tm2 cytoplasmic open response p2x3 cap

P2RX4 relationships Subject–Predicate–Object triples

TTTA extracted 124 structured relationships around P2RX4. Examples in this analysis include P2RX4 → Aliases → P2RX4, P2X4, P2X4R, purinergic receptor P2X 4 and P2RX4 → Band → 12q24.31. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
P2RX4AliasesP2RX4, P2X4, P2X4R, purinergic receptor P2X 41.00infobox
P2RX4Band12q24.311.00infobox
P2RX4Band5 F|5 62.53 cM1.00infobox
P2RX4Bgeemucosa of transverse colon1.00infobox
P2RX4Bgeecerebellar hemisphere1.00infobox
P2RX4Bgeeright hemisphere of cerebellum1.00infobox
P2RX4Bgeegranulocyte1.00infobox
P2RX4Bgeebody of pancreas1.00infobox
P2RX4Bgeemucosa of ileum1.00infobox
P2RX4Bgeemonocyte1.00infobox
P2RX4Bgeerectum1.00infobox
P2RX4Bgeestromal cell of endometrium1.00infobox
P2RX4Bgeemucosa of sigmoid colon1.00infobox
P2RX4BgeeIleal epithelium1.00infobox
P2RX4Bgeelesser wing of sphenoid bone1.00infobox
P2RX4Bgeeparotid gland1.00infobox
P2RX4Bgeenasal septum1.00infobox
P2RX4Bgeesubmandibular gland1.00infobox
P2RX4Bgeelacrimal gland1.00infobox
P2RX4Bgeestroma of bone marrow1.00infobox
P2RX4Bgeeleft colon1.00infobox
P2RX4Bgeeyolk sac1.00infobox
P2RX4Bgeedecidua1.00infobox
P2RX4BioGPSMore reference expression data1.00infobox
P2RX4Chr.Chromosome 12 (human)1.00infobox
P2RX4Chr.Chromosome 5 (mouse)1.00infobox
P2RX4DatabasesNCBI: entry; OMA: entry1.00infobox
P2RX4End121,234,106 bp1.00infobox
P2RX4End122,867,801 bp1.00infobox
P2RX4EnsemblENSG000001351241.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around P2RX4 bring nearby vocabulary together. In this analysis, examples include Protein, P2x and Gene. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • P2RX4
    • Protein
    • P2x
    • Gene
    • Human
    • Location
    • Chromosome
    • Pain
    • Bp
    • Chr
    • Cation
    • Expressed
    • Heteromeric
  • p2rx4
    • Protein
    • P2x
    • Gene
    • Human
    • Location
    • Chromosome
    • Pain
    • Bp
    • Chr
    • Cation
    • Expressed
    • Heteromeric
  • protein
    • Heteromeric
    • Homomeric
    • Activation
    • Human
    • Cation
    • Expressed
    • Location
    • Membrane
    • Purinoceptor
    • Transmembrane
    • Band
    • Binding
  • gene
    • Location
    • Chromosome
    • P2rx4
    • Pain
    • Bp
    • Chr
    • Human
    • Band
    • P2x
    • Protein
    • Subunits
    • Receptor
  • p2x receptor
    • P2rx4
    • Protein
    • Gene
    • Human
    • Receptor
    • Pain
    • Heteromeric
    • Location
    • Purinoceptor
    • Desensitization
    • Chromosome
    • Homomeric
  • homomeric
    • Heteromeric
    • Protein
    • Subunits
    • P2x
    • Cation
    • Expressed
    • Location
    • Membrane
    • Receptors
    • Transmembrane
    • Band
    • Binding
  • heteromeric
    • Homomeric
    • Protein
    • Subunits
    • Cation
    • Expressed
    • Location
    • Membrane
    • P2x
    • Transmembrane
    • Receptors
    • Band
    • Binding
  • ligand-gated cation channels
    • Membrane
    • Binding
    • Response
    • Activation
    • Atp
    • Cell
    • Expressed
    • Heteromeric
    • Location
    • Transmembrane
    • Band
    • Chromosome

Connections between topic areas Semantic bridges

For P2RX4, one of the stronger structural bridges in this analysis connects P2RX4 with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
P2RX4Overview · splits 52 ⟂ 23
P2RX4Structure · splits 60 ⟂ 15
P2RX4Receptor trafficking · splits 62 ⟂ 13
P2RX4Gating mechanism · splits 66 ⟂ 9
P2RX4Neuropathic pain · splits 67 ⟂ 8
P2RX4Pharmacology · splits 69 ⟂ 6

Map overview Semantic statistics

P2RX4

Nodes75
Edges74
Triples124
Avg. degree1.97
Density0.026667
Components1

Source & methodology

TTTA analyzes the structure around P2RX4 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Measurement, Structure & Receptor trafficking, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — P2RX4 · EN edition · Analysis: TopicsToTalkAbout

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