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Osteoclast

An osteoclast (from Ancient Greek ὀστέον (osteon) 'bone' and κλαστός (clastos) 'broken') is a type of bone cell that removes bone tissue. This function is critical in the maintenance, repair, and remodeling of bones of the vertebral skeleton. The osteoclast disassembles and digests the composite of hydrated protein and mineral at a molecular level by…

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Key facts & relationships

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Location
Bone
FMA
66781
Function
Removal of bone tissue
Latin
osteoclastus
MeSH
D010010
Precursor
osteoclast progenitors

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Overview

Structure

Development

Function

Clinical significance

History

Advanced semantic analysis

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Map overview Semantic statistics

Osteoclast

Nodes92
Edges91
Triples94
Avg. degree1.98
Density0.021739
Components1

How this topic connects Entity context

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Osteoclast

Top relations

related to Function · 21
Osteoclast → Arg-Gly-Asp, ATPase, Attachment, Ca2, CO2, Dysfunction, H2CO3, H2O, H3PO4, HCO3, Howship's, Hydrogen, In, MMP, Of, Once, Osteoclasts, Sealing, The, These
related to Development · 10
Osteoclast → After, Both, It, M-CSF, Macrophage, RANKL, Since, Src, These, Three
related to External links · 9
Osteoclast → Animation, Medicine Medical Subject Headings, MedicineNet Archived, MeSH, National Library, OsteoclastRandom42, Random42 Scientific Communication, The Life, Wayback MachineOsteoclasts
related to Location · 8
Osteoclast → At, Golgi, Howship's, In, Osteoclasts, These, This, TRAP
related to Osteoclast physiology · 8
Osteoclast → Cl, Developing, Energy-dependent, HCO3, In, The, This, With
related to Regulation · 7
Osteoclast → IL-6, Osteoclasts, Osteoporosis, PTH, RANK, These, This
related to Matrix metalloproteinases · 6
Osteoclast → It, MMP-9, MMP9, MMPs, The, Transgenic
related to Alternate use of term · 4
Osteoclast → An, Greek, To, When
related to Cathepsin K and other cathepsins · 4
Osteoclast → Cathepsin, It, Knockout, Mutations
related to Structure · 4
Osteoclast → An, The, These, When

Important terminology Word statistics

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Important terminology

osteoclasts bone resorption cathepsin border ruffled cell compartment matrix activity called osteoblasts zone membrane sealing rankl mineral howship's lacunae cells

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
OsteoclastFMA667811.00infobox
OsteoclastFunctionRemoval of bone tissue1.00infobox
OsteoclastLatinosteoclastus1.00infobox
OsteoclastLocationBone1.00infobox
OsteoclastMeSHD0100101.00infobox
OsteoclastPrecursorosteoclast progenitors1.00infobox
OsteoclastTHH2.00.03.7.000051.00infobox
Osteoclastis alarge multinucleated cell and human osteoclasts on bone typically have four nuclei and are 1500.90text
Osteoclastrelated to Alternate use of termAn0.60section
Osteoclastrelated to Alternate use of termGreek0.60section
Osteoclastrelated to Alternate use of termTo0.60section
Osteoclastrelated to Alternate use of termWhen0.60section

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